Sulfated Hydrogel Matrices Direct Mitogenicity and Maintenance of Chondrocyte Phenotype through Activation of FGF Signaling

Fibroblast growth factor signaling in skeletal development and disease

(2015) David M. Ornitz et al.   GENES & DEVELOPMENT

Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings

(2015) Thomas Pap et al.   Nature Reviews Rheumatology

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Heparin-Like Properties of Sulfated Alginates with Defined Sequences and Sulfation Degrees

(2014) Øystein Arlov et al.   BIOMACROMOLECULES

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

(2014) M. M. Martino et al.   SCIENCE

Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications

(2013) Yingkai Liang et al.   Acta Biomaterialia

Molecular engineering of glycosaminoglycan chemistry for biomolecule delivery

(2013) Tobias Miller et al.   Acta Biomaterialia

Incorporation of heparin into biomaterials

(2013) Shelly E. Sakiyama-Elbert   Acta Biomaterialia

Deficiency of Sef Is Associated With Increased Postnatal Cortical Bone Mass by Regulating Runx2 Activity

(2013) Qing He et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The paradox of FGFR3 signaling in skeletal dysplasia: Why chondrocytes growth arrest while other cells over proliferate

(2013) Pavel Krejci   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor

(2013) Thi H. Nguyen et al.   Nature Chemistry

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments

(2013) Marina C Prewitz et al.   NATURE METHODS

Role of the extracellular matrix in regulating stem cell fate

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Chondrocyte Culture in Three Dimensional Alginate Sulfate Hydrogels Promotes Proliferation While Maintaining Expression of Chondrogenic Markers

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Matrix Disruptions, Growth, and Degradation of Cartilage with Impaired Sulfation

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ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation

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Biomaterials in the repair of sports injuries

(2012) Paul Ducheyne et al.   NATURE MATERIALS

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Engineering the Regenerative Microenvironment with Biomaterials

(2012) Jeffrey J. Rice et al.   Advanced Healthcare Materials

Whole-Organ Tissue Engineering: Decellularization and Recellularization of Three-Dimensional Matrix Scaffolds

(2011) Stephen F. Badylak et al.   Annual Review of Biomedical Engineering

The Role of Growth Factors in Cartilage Repair

(2011) Lisa A. Fortier et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Biomaterial-Mediated Delivery of Microenvironmental Cues for Repair and Regeneration of Articular Cartilage

(2011) Wei Seong Toh et al.   MOLECULAR PHARMACEUTICS

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan

(2010) Christine Y. Chuang et al.   BIOCHEMISTRY

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

(2009) Shi-Lu Chia et al.   ARTHRITIS AND RHEUMATISM

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

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The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins

(2008) Inbar Freeman et al.   BIOMATERIALS

Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis

(2008) Michael B. Ellman et al.   GENE

Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification

(2008) C. Settembre et al.   GENES & DEVELOPMENT

Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells

(2008) Danielle S. W. Benoit et al.   NATURE MATERIALS

Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells

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