Article
Chemistry, Applied
Yanjie Hou, Jiaying Zhao, Junyi Yin, Shaoping Nie
Summary: In this study, the structure of BSP and its synergistic interaction with XG were investigated. BSP was found to be a linear polymer with a molecular weight of 323.7 kDa and a mannose to glucose ratio of 2.4:1.0. The BSP/XG mixtures formed a firm and thixotropic gel, with the most pronounced synergistic interaction observed at a BSP/XG ratio of 5:5.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Ping Zhou, Shiyi Zhao, Chi Huang, Yan Qu, Chen Zhang
Summary: The study successfully prepared and characterized Bletilla striata polysaccharide microneedles (BMNs) and investigated their potential as a vaccine carrier. BMNs exhibited excellent mechanical properties and stability, good cell compatibility, and slight irritation to the skin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Baifei Hu, Huabing Yang, Guangming Chen, Xiongjie Sun, Xiaojuan Zou, Jun Ma, Xiaowei Yao, Qiong Liang, Hongtao Liu
Summary: This study demonstrated the potential of Bletilla striata oligosaccharides (BOs) as a functional food for the treatment of non-alcoholic fatty liver disease (NAFLD). By regulating hepatic metabolism and reducing lipid accumulation and fibrosis, BOs showed improvement in NAFLD.
Article
Plant Sciences
Lan Jiang, Mengfei Lin, Han Wang, Hui Song, Lin Zhang, Qingyu Huang, Renrui Chen, Cheng Song, Guohui Li, Yunpeng Cao
Summary: This study presents a high-quality haplotype-resolved genome of B. striata and explores its genomic evolution and polysaccharide biosynthesis, providing important insights into the evolution of orchids and the improvement of medicinal value in B. striata.
Article
Chemistry, Analytical
Bo Sun, Wenxin Zhang, Yangyang Liu, Min Xue, Lili Qiu, Zihui Meng
Summary: A polysaccharide-based semi-interpenetrating network hydrogel was constructed by introducing BSP, which not only maintained the mechanical properties of the material but also endowed it with good biocompatibility. By implanting colloidal crystal arrays, a biomass-based photonic crystal sensitive to volatile organic compounds was obtained.
Article
Materials Science, Multidisciplinary
Kaijun Gou, Yuan Li, Yan Qu, Heran Li, Rui Zeng
Summary: This article introduces the characteristics and potential applications of Bletilla striata polysaccharide (BSP) as a promising biomaterial. Both unmodified and chemically modified BSP have wide application value in wound healing, targeted drug delivery, and tissue engineering. The preparation, characterization, and structure properties of BSP-based biomaterials are summarized, and the current challenges and future prospects are highlighted.
MATERIALS & DESIGN
(2022)
Article
Integrative & Complementary Medicine
Jiaxi Chen, Huiqun Zhou, Daping Xie, Yiming Niu
Summary: The study demonstrates the fabrication of cryogels with different pore sizes and moduli by adjusting concentration, showing good cytocompatibility and upregulated pro-inflammation gene expression with increasing pore size. In vivo experiments confirm that larger pore sizes attract more immune cell infiltration. Modulating material microstructure can control foreign-body reaction and immune cell distribution, impacting material-tissue integration. This work provides a practical strategy for regulating foreign body reaction and enhancing medical device performance.
Article
Materials Science, Multidisciplinary
Jinying Lv, Hongyu Ma, Gengsheng Ye, Shiami Jia, Juan He, Wuni Jiaduo, Jie Ma, Yan Qu, Kaijun Gou, Rui Zeng
Summary: In this study, a transdermal drug delivery system of BSP/CS composite dissolvable microneedles (CS-AS-BSP MNs) containing AS was developed. The system improved the solubility of AS and achieved a stable and long-lasting drug release. The CS-AS-BSP MNs showed a good antibacterial effect, reduced scar fibroblast proliferation, and demonstrated a scarless wound healing effect in a rat model.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Multidisciplinary
Wen Cheng, Fangmei Zhou, Bingqi Zhu, Xinghong Ding, Jingjing Lu, Chaodong Qian, Xiaoqing Ye, Zhishan Ding
Summary: The study developed a multifunctional composite sponge dressing with hemostatic, anti-inflammatory, antibacterial, and wound healing promotion properties. In vivo and in vitro evaluations showed significant hemostatic and antibacterial effects, along with good biodegradability and biocompatibility. Experimental results demonstrated the sponge's effectiveness in promoting wound healing.
MATERIALS & DESIGN
(2021)
Article
Pharmacology & Pharmacy
Yan Zhao, Qibin Wang, Shan Yan, Jun Zhou, Liangyong Huang, Haitao Zhu, Fang Ye, Yonghong Zhang, Lin Chen, Li Chen, Tao Zheng
Summary: Bletilla striata polysaccharide accelerates diabetic wound healing, suppresses macrophage infiltration, promotes angiogenesis, inhibits NLRP3 inflammasome activation, and improves insulin sensitivity in wound tissues in diabetic mice. It also protects against high glucose-induced ROS generation and NLRP3 inflammasome activation in vitro, while improving cell viability and insulin sensitivity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan He, Gengsheng Ye, Hongyu Ma, Shiami Jia, Jie Ma, Jinying Lv, Duowuni Jia, Yi Song, Fangyao Liu, Ping Li, Jun Wang, Kunsang Gyal, Kaijun Gou, Mujia La, Rui Zeng
Summary: This study aimed to develop a multifunctional sponge dressing for full-stage wound healing based on copper, Bletilla striata polysaccharide (BSP), and peony leaf extract (PLE). The BSP-Cu-PLE sponges exhibited improved water absorption and porosity, as well as excellent antioxidative, biocompatible, and biodegradable properties. They also demonstrated superior antibacterial activity and enhanced hemostatic activity. Furthermore, the BSP-Cu-PLE sponges significantly accelerated the healing process of skin wounds by stimulating collagen deposition, promoting angiogenesis, and decreasing inflammatory cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Tianyu Chen, Xiaoyan Guo, Yiping Huang, Wentao Hao, Sunyan Deng, Gewen Xu, Junjie Bao, Qiansheng Xiong, Wen Yang
Summary: Polysaccharides are widely used in biomedicine due to their unique biological activity, low costs, and easy accessibility. In this study, Bletilla striata polysaccharide (BSP) was integrated into waterborne polyurethane (WPU) to prepare a series of hydrogels. These hydrogels showed good performance in terms of compressive strength, water absorption and retention, and biocompatibility. The WPUB hydrogel dressings demonstrated excellent ability in promoting wound healing, with reduced wound surface area and improved skin quality compared to conventional gauze.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Biochemistry & Molecular Biology
Jinxi Xiang, Youjie Wang, Luping Yang, Xiaojia Zhang, Yanlong Hong, Lan Shen
Summary: The newly developed polysaccharide-based hydrogel exhibits good mechanical properties and blood compatibility, making it suitable for applications as a hemostatic material, drug carrier, and tissue engineering scaffold.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Zhengbo Hu, Kai Zhao, Xingcan Chen, Mingyuan Zhou, Yuchi Chen, Xiaoqing Ye, Fangmei Zhou, Zhishan Ding, Bingqi Zhu
Summary: The developed BSP/BER hydrogel exhibited excellent biocompatibility and remarkable antibacterial, anti-inflammatory, and antioxidant properties. Animal experiments demonstrated that the hydrogel significantly accelerated wound healing in diabetic mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Man Zhang, Dong Luo, Hailing Fang, Wei Zhao, Ying Zheng
Summary: Blue film light treatment promotes the growth of aerial parts in Bletilla striata plants and increases the total phenol and militarine content in the tubers without affecting polysaccharide accumulation.
JOURNAL OF PLANT PHYSIOLOGY
(2022)