Article
Pharmacology & Pharmacy
Bence Sipos, Maria Budai-Szucs, David Kokai, Laszlo Orosz, Katalin Burian, Anita Csorba, Zoltan Zsolt Nagy, Gyorgy Tibor Balogh, Ildiko Csoka, Gabor Katona
Summary: This study aimed to create a value-added formulation with a powerful and long-lasting antibacterial effect for use in ophthalmology. Erythromycin-loaded polymeric micelles were dispersed in a gel base to prolong drug release and enhance corneal permeability. The optimized gel formulation exhibited high mucoadhesion and elevated permeability into the aqueous humour, making it a potential innovative ophthalmic formulation for treating bacterial infections of the eye.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Yi Wang, Wenchao Wang, Endian Yu, Wenya Zhuang, Xuanrong Sun, Hong Wang, Qingyong Li
Summary: In this study, FLQY2-SD was successfully prepared and it was found to improve the solubility and bioavailability of FLQY2. Pharmacokinetic and pharmacodynamic studies showed that FLQY2-SD had a higher tumor growth inhibition rate in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Rosario Pignatello, Roberta Corsaro, Angela Bonaccorso, Elide Zingale, Claudia Carbone, Teresa Musumeci
Summary: This study characterized Soluplus(R) nanomicelles to enhance the apparent solubility of drugs in BCS class II. The prepared nanomicelles showed small and stable particle size and could be easily filtered. The freeze-dried powder materials maintained the micelle size upon reconstitution. Additionally, the nanomicelles demonstrated potential applications in topical ocular administration.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Mohammad Atif Faiz Afzal, Kristin Lehmkemper, Ekaterina Sobich, Thomas F. Hughes, David J. Giesen, Teng Zhang, Caroline M. Krauter, Paul Winget, Matthias Degenhardt, Samuel O. Kyeremateng, Andrea R. Browning, John C. Shelley
Summary: Amorphous solid dispersions (ASDs) are commonly used for oral delivery of poorly water-soluble small-molecule drugs. Producing a high-performance ASD involves considering factors such as drug solubility in the matrix and drug release rate in aqueous medium. Molecular dynamics simulations provide unique insights into the dissolution behavior mechanisms of ASDs. The study shows that polymer microstructures and drug-polymer interactions play important roles in the dissolution behavior of ASDs.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Vijayabhaskarreddy Junnuthula, Amir Sadeghi Boroujeni, Shoupeng Cao, Shirin Tavakoli, Roxane Ridolfo, Elisa Toropainen, Marika Ruponen, Jan C. M. van Hest, Arto Urtti
Summary: This study synthesized and characterized block copolymers that self-assembled into polymersomes and polymeric micelles, which showed stability and diffusibility in the vitreous and no cellular toxicity. Pharmacokinetic evaluation in rabbits showed prolonged half-lives and retention of these nanocarriers in the vitreous, making them promising for controlled and site-specific drug delivery in the posterior eye segment.
Article
Pharmacology & Pharmacy
Pallavi Sharma, Ruchika, Poonam Dhiman, Rajneesh Kumar, Ankit Saneja, Damanpreet Singh
Summary: Flavonoids, the main compounds in citrus plants, have potential beneficial effects in epileptic seizures, but poor solubility and bioavailability limit their use. This study developed a solid dispersion of citrus peel flavonoids to improve their solubility and antiseizure efficacy. The results showed that the solid dispersion significantly reduced hyperactive responses and delayed seizure onset in a zebrafish seizure model, and it also enhanced the dissolution of the major flavonoid in an in vitro test. This study suggests that solid dispersion is a promising strategy to enhance the therapeutic efficacy of citrus peel flavonoids.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Lais Ribovski, Naomi M. Hamelmann, Jos M. J. Paulusse
Summary: Safe and reliable entry into the brain is crucial for successful treatment of central nervous system disorders, but remains challenging. Nano-sized systems as drug carriers show significant improvements in therapy delivery. Careful design of NP properties is essential for successful brain delivery, affecting the ability to overcome multiple barriers.
Article
Materials Science, Biomaterials
Jyoti Chhimwal, Rakesh Kumar Dhritlahre, Prince Anand, Vikram Ruchika, Vikram Patial, Ankit Saneja, Yogendra S. Padwad
Summary: The amorphous solid dispersion of phloretin (Ph-SD) showed potential therapeutic effects in the treatment of non-alcoholic fatty liver disease (NAFLD). The formulation improved the solubility and oral bioavailability of phloretin and reduced fibrotic changes in the liver tissues by blocking the mTOR/SREBP-1c pathway.
BIOMATERIALS ADVANCES
(2023)
Review
Polymer Science
Suguna Perumal, Raji Atchudan, Wonmok Lee
Summary: This review discusses the self-assembly of amphiphilic polymers into micelles (polymeric nanoparticles) and their importance in bio-applications. Micelles, with their unique properties, size, shape, and biocompatibility, enhance drug loading and target release, making them a research focus in the field of biomedicine.
Article
Pharmacology & Pharmacy
Eman Gomaa, Mohamed S. Attia, Fakhr-Eldin S. Ghazy, Abdalla E. A. Hassan, Azza A. Hasan
Summary: This study aimed to enhance the dissolution rate of Ultragriseofulvin (UGF) by using a high voltage-based solvent evaporation technique to form Amorphous Solid Dispersions (ASDs) with the modified polyethylene glycol grafted copolymer, Soluplus (R) (SOL). The electrosprayed UGF/SOL NPs demonstrated improved wettability and a significant increase in the invitro dissolution compared to raw UGF. This research highlights the impact of the electrospraying technique on the dissolution of poorly water-soluble drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lourdes Valdivia, Lorena Garcia-Hevia, Manuel Banobre-Lopez, Juan Gallo, Rafael Valiente, Monica Lopez Fanarraga
Summary: Solid lipid particles (SLPs) can effectively encapsulate and release therapeutic agents over long periods, reducing the number of metastatic foci in the lung. In vitro kinetic studies show two distinctive drug release profiles, providing the possibility for further clinical applications.
Review
Pharmacology & Pharmacy
Genada Sinani, Meltem Ezgi Durgun, Erdal Cevher, Yildiz Ozsoy
Summary: Nucleic acids can regulate gene expression specifically and have huge potential in disease prevention and treatment. However, their clinical translation is challenging due to rapid clearance, low stability, and limited cellular uptake. Polymeric micelles have emerged as suitable delivery vehicles for nucleic acids, with their versatile structures and ability to overcome barriers and enhance therapeutic efficacy. Various strategies, such as stimuli-sensitive groups and specific ligands, can be used to improve delivery, targeting, and cellular uptake of nucleic acids. Additionally, polymeric micelles can deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously, achieving synergistic combination treatment.
Article
Instruments & Instrumentation
Wenjie Fan, Haijie Han, Yaoyao Chen, Xiaobo Zhang, Yifan Gao, Su Li, Qiao Jin, Jian Ji, Ke Yao
Summary: Ocular infection caused by bacteria and fungi is a major cause of visual impairment and blindness. Traditional treatment with eye drops is inefficient, while nanomedicine provides a promising platform for enhancing the delivery of antimicrobial agents to the eye.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Xiaomin Huang, Luoyuan Li, Zhongxing Chen, Haoyu Yu, Xinru You, Na Kong, Wei Tao, Xingtao Zhou, Jinhai Huang
Summary: Ocular bacterial infection, a common cause of blindness, has significant consequences for daily life. The rapid advancement of nanoscience and biomedicine has led to the increasing attention on multifunctional nanosystems as a potential solution to ocular bacterial infections. This review highlights the challenges faced by ocular medicine and encourages basic research and future clinical transformation based on ophthalmic antibacterial nanomedicine.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Ivana Jarak, Miguel Pereira-Silva, Ana Claudia Santos, Francisco Veiga, Horacio Cabral, Ana Figueiras
Summary: PMs are efficient NA delivery platforms that can manipulate gene expression and have enormous potential for treating life-threatening diseases. The facile manipulation of polymeric building blocks allows for tuning crucial parameters for NA protection and targeted delivery.
APPLIED MATERIALS TODAY
(2021)