期刊
FRONTIERS IN ONCOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2018.00505
关键词
cancer cell dormancy; EMT; MET; cellular phenotype plasticity; cancer metastasis
类别
资金
- National Natural Science Foundation of China [81772891, 81672672, 81572650, 81502357, 81621062]
- Natural Science Foundation of Zhejiang Province [Q142114001]
- Zhoushan Science and Technology Bureau Project [2014C3106]
- National Program on Key Research Project of China [2016YFC0902700]
Cancer dormancy is a period of cancer progression in which residual tumor cells exist, but clinically remain asymptomatic for a long time, as well as resistant to conventional chemo- and radiotherapies. Cellular phenotype plasticity represents that cellular phenotype could convert between epithelial cells and cells with mesenchymal traits. Recently, this process has been shown to closely associate with tumor cell proliferation, cancer dormancy andmetastasis. In this review, we have described different scenarios of how the transition from epithelial to mesenchymal morphology (EMT) and backwards (MET) are connected with the initiation of dormancy and reactivation of proliferation. These processes are fundamental for cancer cells to invade tissues and metastasize. Recognizing the mechanisms underlying the cellular phenotype plasticity as well as dormancy and targeting them is likely to increase the efficiency of traditional tumor treatment inhibiting tumor metastasis.
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