Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling

The MST4–MOB4 complex disrupts the MST1–MOB1 complex in the Hippo–YAP pathway and plays a pro-oncogenic role in pancreatic cancer

(2018) Min Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome

(2018) Xiaoyan Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex

(2017) Yonggang Zheng et al.   Cell Reports

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

(2017) Sung Jun Bae et al.   eLife

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores

(2016) Arsen Petrovic et al.   CELL

STRIPAK complexes in cell signaling and cancer

(2016) Z Shi et al.   ONCOGENE

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

TRAF3IP3, a novel autophagy up-regulated gene, is involved in marginal zone B lymphocyte development and survival

(2015) S. Peng et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

(2015) Lisheng Ni et al.   GENES & DEVELOPMENT

MST kinases in development and disease

(2015) Barry J. Thompson et al.   JOURNAL OF CELL BIOLOGY

T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi

(2015) Qiang Zou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

YAP is essential for tissue tension to ensure vertebrate 3D body shape

(2015) Sean Porazinski et al.   NATURE

The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6

(2015) Shi Jiao et al.   NATURE IMMUNOLOGY

CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling

(2015) Benjamin Lant et al.   Nature Communications

Daytime CLOCK Dephosphorylation Is Controlled by STRIPAK Complexes in Drosophila

(2015) Simonetta Andreazza et al.   Cell Reports

Structural dissection of Hippo signaling

(2014) Z. Shi et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The Hippo signaling pathway in liver regeneration and tumorigenesis

(2014) L. Hong et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

(2014) Shi Jiao et al.   CANCER CELL

Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2:2 Heterotetrameric Core of Striatin-interacting Phosphatase and Kinase (STRIPAK) Complex

(2014) Cuicui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STRIPAK components determine mode of cancer cell migration and metastasis

(2014) Chris D. Madsen et al.   NATURE CELL BIOLOGY

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

STRIPAK complexes: Structure, biological function, and involvement in human diseases

(2013) Juyeon Hwang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1

(2013) Simon Hauri et al.   Molecular Systems Biology

Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

(2013) A. L. Couzens et al.   Science Signaling

Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism

(2013) Zhubing Shi et al.   STRUCTURE

Tethering the assembly of SNARE complexes

(2013) WanJin Hong et al.   TRENDS IN CELL BIOLOGY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Germinal center kinases in immune regulation

(2012) Hailei Yin et al.   Cellular & Molecular Immunology

Misshapen-like kinase 1 (MINK1) Is a Novel Component of Striatin-interacting Phosphatase and Kinase (STRIPAK) and Is Required for the Completion of Cytokinesis

(2012) Toshinori Hyodo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3

(2011) Johnthan Gordon et al.   BMC BIOCHEMISTRY

Structure-Function Analysis of Core STRIPAK Proteins

(2011) Michelle J. Kean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

(2010) Paulo S. Ribeiro et al.   MOLECULAR CELL

Small Cytoskeleton-Associated Molecule, Fibroblast Growth Factor Receptor 1 Oncogene Partner 2/Wound Inducible Transcript-3.0 (FGFR1OP2/wit3.0), Facilitates Fibroblast-Driven Wound Closure

(2009) Audrey Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

The DeMSTification of Mammalian Ste20 Kinases

(2009) Maria Radu et al.   CURRENT BIOLOGY

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

(2009) Timo Glatter et al.   Molecular Systems Biology

Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling

(2009) A H Beck et al.   ONCOGENE

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

(2008) Marilyn Goudreault et al.   MOLECULAR & CELLULAR PROTEOMICS