Review
Pharmacology & Pharmacy
Xiaoya Li, Huihui Xu, Jing Huang, Dan Luo, Shuang Lv, Xiangchen Lu, Cheng Xiao
Summary: Regulatory T cells (Tregs) play a crucial role in promoting immune tolerance and maintaining immune system homeostasis. Dysfunction of Tregs is closely linked to rheumatoid arthritis (RA), and research on Tregs in RA has made significant progress in both basic and clinical aspects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Fatemeh Bayati, Mahsa Mohammadi, Maryam Valadi, Saeid Jamshidi, Arron Munggela Foma, Ehsan Sharif-Paghaleh
Summary: Regulatory T cells (Tregs) are a subgroup of CD4(+) T cells that play a key role in immune tolerance regulation, preventing autoimmunity and aiding tumor evasion of immune recognition. Their therapeutic potential in transplantation, autoimmune diseases, and cancer therapy is being actively studied for improving treatment options.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Victoria Volfson-Sedletsky, Albert Jones, Jaileene Hernandez-Escalante, Hans Dooms
Summary: Despite decades of research, translating autoimmune mechanisms underlying Type 1 Diabetes into effective therapeutics remains challenging. Restoring Treg functions to target specific autoantigens or localize in the pancreas is a sought-after strategy for treating the disease. Developing precise Treg therapies beyond broad activation is promising, with a focus on ex vivo generation and in situ stimulation of optimized Tregs.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xinyi Xiao, Yazhuo Wang, Zhengbang Zou, Yufei Yang, Xinyu Wang, Xin Xin, Sanfang Tu, Yuhua Li
Summary: Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies, but there are limitations such as resistance and relapse. In this review, we summarize rational combined modality treatments to enhance the effectiveness of CAR T cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Kamira Maharaj, Angimar Uriepero, Eva Sahakian, Javier Pinilla-Ibarz
Summary: Regulatory T cells (Tregs) play a crucial role in B-cell lymphoid malignancies, with increased levels correlating with clinical outcomes. Tregs can be induced directly by tumor cells and suppress antitumor immunity in the tumor microenvironment, facilitating disease progression. Furthermore, Tregs can be modulated by novel therapeutic agents, such as immune checkpoint blockade and targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell & Tissue Engineering
Yongqing Zhao, Min Wang, Feng Liang, Jiannan Li
Summary: Skin wound healing is a complex process involving various cells and mediators, and dysregulation can lead to chronic or non-healing wounds. Stem cell therapy has shown significant advancements in wound regeneration, particularly utilizing mesenchymal stem cells, but there are challenges with limited cell efficacy and underutilized therapeutic potential. Innovations are needed to enhance stem cell efficacy for better clinical outcomes.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Jin-Ming Yang, Yijie Ren, Anil Kumar, Xiaofang Xiong, Jugal Kishore Das, Hao-Yun Peng, Liqing Wang, Xingcong Ren, Yi Zhang, Cheng Ji, Yan Cheng, Li Zhang, Robert C. Alaniz, Paul de Figueiredo, Deyu Fang, Hongwei Zhou, Xiaoqi Liu, Jianlong Wang, Jianxun Song
Summary: This study shows that NAC1 plays a role in regulating the expression of FoxP3 in regulatory T cells, thereby affecting immune tolerance. NAC1-deficient mice display increased tolerance to autoimmunity and higher levels of immune-suppressive CD4(+) T-regs cells which exhibit enhanced metabolic profile and activity. These findings suggest that NAC1 destabilizes T-regs and suppresses tolerance induction, indicating its potential as a target for tolerogenic strategies in treating autoimmune disorders.
Review
Biochemistry & Molecular Biology
Meng-Chien Willie Hsieh, Wei-Ting Wang, Chuang-Yu Lin, Yur-Ren Kuo, Su-Shin Lee, Ming-Feng Hou, Yi-Chia Wu
Summary: This review summarizes the therapeutic benefits of using various types of stem cells, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, and adipose-derived stem cells, in diabetic wound healing. The focus is on autologous adipose-derived stem cells and laboratory expandable induced pluripotent stem cells. The study aims to shed more light on this attractive therapy in order to improve the efficacy of wound healing in diabetic patients.
Review
Medicine, Research & Experimental
Ali Zarezadeh Mehrabadi, Reza Ranjbar, Mahdieh Farzanehpour, Alireza Shahriary, Ruhollah Dorostkar, Mohammad Ali Hamidinejad, Hadi Esmaeili Gouvarchin Ghaleh
Summary: CAR-T cell therapy shows great potential in cancer treatment, but faces challenges in treating solid tumors. Combining with other therapeutic approaches may enhance the efficacy of CAR-T cells, but further research is needed to determine their safety and effectiveness.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Wookyeom Yang, Dasol Kim, Dae Kyoung Kim, Kyung Un Choi, Dong Soo Suh, Jae Ho Kim
Summary: Ovarian cancer is a fatal gynecological malignancy, and its treatment remains a challenge. Cancer stem cells (CSCs) play a key role in cancer relapse and treatment resistance, with their malignancy regulated by cell surface receptors and intracellular factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Anne E. J. Hillen, Prisca S. Leferink, Nicole B. Breeuwsma, Stephanie Dooves, Talia Bergaglio, Marjo S. Van Der Knaap, Vivi M. Heine
Summary: The transplantation of human glial cell populations has therapeutic effects for VWM. However, the microenvironment in the VWM patient brain should be considered as an important moderator of cell replacement therapy before further translation to the clinic.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Oncology
Feng Shan, Ashwin Somasundaram, Tullia C. Bruno, Creg J. Workman, Dario A. A. Vignali
Summary: The success of immunotherapy in oncology highlights the important role of the immune system in cancer development. Regulatory T cells (Tregs) play multiple roles in the tumor microenvironment, particularly in suppressing T cell activation. Understanding the subpopulations of Tregs and their functions within the complex networks of the tumor microenvironment is crucial for the development of next-generation immunotherapies.
Editorial Material
Cell & Tissue Engineering
Benjamin H. Goldenson, Dan S. Kaufman
Summary: The study demonstrates that expression of modified CD16a and IL-15 receptor combined with knockout of CD38 can enhance NK cell-mediated activity against leukemia and multiple myeloma.
Review
Cell Biology
Raheleh Farahzadi, Behnaz Valipour, Soheila Montazersaheb, Ezzatollah Fathi
Summary: Adult stem cells (ASCs) throughout the body can support tissue growth and repair. The function of stem cells is influenced by signals derived from their specific microenvironment or niche. Studies have shown that aging of the niche can lead to a decline in stem cell function and is associated with aging and age-related disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Carsten Riether
Summary: Adult bone marrow hematopoietic stem cells (HSCs) maintain their function through interactions with regulatory T cells (Tregs). In leukemia, these regulatory mechanisms are disrupted, leading to compromised treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)