期刊
CELLS
卷 8, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/cells8010005
关键词
mitochondria; endoplasmic reticulum; MERCs; MAMs; obesity; neurodegenerative diseases; microscopy
类别
资金
- FFARB 2017
- University of Brescia (Italy)
- Spanish Ministerio de Economia Industria y Competitividad (MINEICO), FEDER funds [SAF2015-63904-R]
- European Union [721236-TREATMENT]
The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration.
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