期刊
CELLS
卷 7, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/cells7120243
关键词
miR-1611; lncRNA-Six1; Six1; myoblast proliferation; myoblast differentiation; transformation of muscle fiber types
类别
资金
- Natural Scientific Foundation of China [31472090]
- Science and Technology Planning Project of Guangzhou City [201604020007, 201504010017]
- Ten-Thousand Talents Program [W03020593]
Emerging studies indicate important roles for non-coding RNAs (ncRNAs) as essential regulators in myogenesis, but relatively less is known about their function. In our previous study, we found that lncRNA-Six1 can regulate Six1 in cis to participate in myogenesis. Here, we studied a microRNA (miRNA) that is specifically expressed in chickens (miR-1611). Interestingly, miR-1611 was found to contain potential binding sites for both lncRNA-Six1 and Six1, and it can interact with lncRNA-Six1 to regulate Six1 expression. Overexpression of miR-1611 represses the proliferation and differentiation of myoblasts. Moreover, miR-1611 is highly expressed in slow-twitch fibers, and it drives the transformation of fast-twitch muscle fibers to slow-twitch muscle fibers. Together, these data demonstrate that miR-1611 can mediate the regulation of Six1 by lncRNA-Six1, thereby affecting proliferation and differentiation of myoblasts and transformation of muscle fiber types.
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