Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

Modulation of Inflammation as a Way of Delaying Alzheimer's Disease Progression: The Diet's Role

(2018) R. Businaro et al.   Current Alzheimer Research

Tetrahydroxystilbene glycoside antagonizes β-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression

(2018) Chenli Jiao et al.   NEUROREPORT

Protective effect of carnosine on white matter damage in corpus striatum induced by chronic cerebral hypoperfusion

(2018) Jing Ma et al.   NEUROSCIENCE LETTERS

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

(2018) Filippo Caraci et al.   PHARMACOLOGICAL RESEARCH

Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment

(2018) Dunja Knezevic et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells

(2018) Claudia G. Fresta et al.   Cell Death & Disease

The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death

(2018) Sara Merlo et al.   Scientific Reports

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

(2018) William L. Klein   JOURNAL OF ALZHEIMERS DISEASE

Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells

(2018) Giuseppe Caruso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders

(2018) Giuseppe Caruso et al.   PROGRESS IN NEUROBIOLOGY

Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity

(2017) Giuseppa Ida Grasso et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microglial Activation Results in Inhibition of TGF-β-Regulated Gene Expression

(2017) Kwame Ofori Affram et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Carnosine modulates nitric oxide in stimulated murine RAW 264.7 macrophages

(2017) Giuseppe Caruso et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cytokine Signatures in Mucocutaneous and Ocular Behçet’s Disease

(2017) Giuseppe Lopalco et al.   Frontiers in Immunology

Inflammatory Aspects of Alzheimer Disease and Other Neurodegenerative Disorders

(2017) Claudia Schwab et al.   JOURNAL OF ALZHEIMERS DISEASE

Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake

(2017) Michael J. Cripps et al.   Scientific Reports

Neuroprotective effect of carnosine on primary culture of rat cerebellar cells under oxidative stress

(2016) A. V. Lopachev et al.   BIOCHEMISTRY-MOSCOW

Reduction of Oxidative/Nitrosative Stress in Brain and its Involvement in the Neuroprotective Effect of n-3 PUFA in Alzheimer's Disease

(2016) Simona Serini et al.   Current Alzheimer Research

Protective effects of carnosine on dehydroascorbate-induced structural alteration and opacity of lens crystallins: important implications of carnosine pleiotropic functions to combat cataractogenesis

(2016) Sajjad Javadi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide

(2016) Miriam Ries et al.   Journal of Neuroinflammation

Receptor-mediated toxicity of human amylin fragment aggregated by short- and long-term incubations with copper ions

(2016) Giuseppe Caruso et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Carnosine Attenuates Brain Oxidative Stress and Apoptosis After Intracerebral Hemorrhage in Rats

(2016) Rong-xia Xie et al.   NEUROCHEMICAL RESEARCH

Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1

(2016) Filippo Caraci et al.   Frontiers in Pharmacology

Mitochondrial superoxide: a key player in Alzheimer's disease

(2016) Cynthia A. Massaad et al.   Aging-US

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Indirect detection of superoxide in RAW 264.7 macrophage cells using microchip electrophoresis coupled to laser-induced fluorescence

(2015) Richard P. S. de Campos et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1–42)-induced toxicity

(2015) Filippo Caraci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reversible redox modifications in the microglial proteome challenged by beta amyloid

(2015) Virginia Correani et al.   Molecular BioSystems

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

(2015) Maria L. Giuffrida et al.   Frontiers in Cellular Neuroscience

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Microchip electrophoresis with amperometric detection method for profiling cellular nitrosative stress markers

(2014) Dulan B. Gunasekara et al.   ANALYST

Age-dependent changes on TGFβ1 Smad3 pathway modify the pattern of microglial cell activation

(2014) Juan E. Tichauer et al.   BRAIN BEHAVIOR AND IMMUNITY

Carnosine Attenuates Early Brain Injury Through Its Antioxidative and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model

(2014) Zong-yong Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

An Integrated Microfluidic Device for Monitoring Changes in Nitric Oxide Production in Single T-Lymphocyte (Jurkat) Cells

(2013) Eve C. Metto et al.   ANALYTICAL CHEMISTRY

Carnosine Inhibits Aβ42Aggregation by Perturbing the H-Bond Network in and around the Central Hydrophobic Cluster

(2013) Francesco Attanasio et al.   CHEMBIOCHEM

Glia: An Important Target for Anti-Inflammatory and Antidepressant Activity

(2013) Sadayuki Hashioka et al.   CURRENT DRUG TARGETS

Fucoxanthin Ameliorates Inflammation and Oxidative Reponses in Microglia

(2013) Ratih Pangestuti et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Anti-Aggregating Effect of the Naturally Occurring Dipeptide Carnosine on Aβ1-42 Fibril Formation

(2013) Alessandra Aloisi et al.   PLoS One

Monitoring intracellular nitric oxide production using microchip electrophoresis and laser-induced fluorescence detection

(2012) Emilie R. Mainz et al.   Analytical Methods

Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice

(2012) Jing Ma et al.   CNS Neuroscience & Therapeutics

Antioxidant Therapies for Neurodegenerative Diseases: Mechanisms, Current Trends, and Perspectives

(2012) Daniel Pens Gelain et al.   Oxidative Medicine and Cellular Longevity

Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signaling

(2011) Konstantin Kulebyakin et al.   AMINO ACIDS

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice

(2011) Carlo Corona et al.   PLoS One

The Monomer State of Beta-Amyloid: Where the Alzheimer's Disease Protein Meets Physiology

(2011) M.L. Giuffrida et al.   REVIEWS IN THE NEUROSCIENCES

Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

(2011) Andrew D. Kraft et al.   International Journal of Environmental Research and Public Health

Decreased expression of GRAF1/OPHN-1-L in the X-linked alpha thalassemia mental retardation syndrome

(2010) Vincenza Barresi et al.   BMC Medical Genomics

Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: Possible pharmacological strategies

(2010) Tomohiro Nakamura et al.   CELL CALCIUM

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Transforming growth factor beta and soluble endoglin in the healthy senior and in Alzheimer’s disease patients

(2010) B. Juraskova et al.   Journal of Nutrition Health & Aging

Targeting Group II Metabotropic Glutamate (mGlu) Receptors for the Treatment of Psychosis Associated with Alzheimer's Disease: Selective Activation of mGlu2 Receptors Amplifies  -Amyloid Toxicity in Cultured Neurons, Whereas Dual Activation of mGlu2 and mGlu3 Receptors Is Neuroprotective

(2010) F. Caraci et al.   MOLECULAR PHARMACOLOGY

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

GROWTH FACTORS DECREASE IN SUBJECTS WITH MILD TO MODERATE ALZHEIMER'S DISEASE (AD): POTENTIAL CORRECTION WITH DEHYDROEPIANDROSTERONE-SULPHATE (DHEAS)

(2009) C. Luppi et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Protective Effects ofl- andd-Carnosine on α-Crystallin Amyloid Fibril Formation: Implications for Cataract Disease

(2009) Francesco Attanasio et al.   BIOCHEMISTRY

Inhibitory effect of carnosine and N-acetyl carnosine on LPS-induced microglial oxidative stress and inflammation

(2009) Sigal Fleisher-Berkovich et al.   PEPTIDES

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

The Wnt Antagonist, Dickkopf-1, as a Target for the Treatment of Neurodegenerative Disorders

(2008) Filippo Caraci et al.   NEUROCHEMICAL RESEARCH

TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts

(2008) F CARACI et al.   PHARMACOLOGICAL RESEARCH

Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease

(2007) Leonel E. Rojo et al.   ARCHIVES OF MEDICAL RESEARCH