Review
Medicine, Research & Experimental
Daciana Elena Branisteanu, Alin Codrut Nicolescu, Daniel Constantin Branisteanu, Catalina Ioana Branisteanu, Andreea Corina Dragoi, Camelia Margareta Bogdanici, Mihaela Paula Toader, Andreea Lorena Tucaliuc, Andreea Dimitriu, Doru Daogaru, Ruxandra Angela Pirvulescu, Elena Andrese Porumb
Summary: Psoriasis, previously considered as a skin-limited condition, is now recognized as a chronic, immune-mediated inflammatory disease with systemic manifestations. Besides the skin changes, it is associated with important comorbidities, such as psoriatic arthritis, cardiovascular disease, diabetes, and inflammatory bowel disease. Psoriasis is also an independent risk factor for cardiovascular diseases, and biological therapy may have an effect on atherosclerosis regression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Vasilis Nikolaou, Sebastiano Massaro, Wolfgang Garn, Masoud Fakhimi, Lampros Stergioulas, David Price
Summary: In this study, three subtypes of the COPD cardiovascular phenotype were identified in UK patients, each characterized by different features and disease profiles. The random forest model was found to be the most accurate for predicting cardiovascular comorbidities in COPD patients with the cardiovascular phenotype.
RESPIRATORY MEDICINE
(2021)
Review
Critical Care Medicine
Deepti Singhvi, Jessica Bon
Summary: Comorbidities significantly impact COPD patients, and targeted early screening and treatment may have a significant effect on COPD outcomes. Recent studies suggest that certain radiographic features can serve as surrogate markers for comorbid disease in COPD patients.
Article
Biochemistry & Molecular Biology
Kaschin Jamal Jameel, Willem-Jakob Gallert, Sarah D. Yanik, Susanne Panek, Juliane Kronsbein, David Jungck, Andrea Koch, Jurgen Knobloch
Summary: In smoking-induced COPD, patients with various comorbidities may have suppressed T-cell immunity, leading to a potential explanation for the association with frequent exacerbations. Different biomarkers at varying concentrations can modulate T-cell activation markers, with a clear shift towards suppressive effects, particularly for asthma- and cancer-related comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Virginia Valentini, Valentina Silvestri, Agostino Bucalo, Federica Marraffa, Maria Risicato, Sara Grassi, Giovanni Pellacani, Laura Ottini, Antonio Giovanni Richetta
Summary: Cardiovascular disease is a common comorbidity in psoriatic patients. The etiology and progression of both psoriasis and cardiovascular disease involve various factors, including genetics and gut microbiome dysbiosis. This study found a higher prevalence of Barnesiellaceae and Phascolarctobacterium in the gut microbiome of psoriatic patients with cardiovascular disease. Psoriatic patients undergoing biologic therapy had lower levels of Barnesiellaceae, comparable to those without cardiovascular disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zsuzsanna Miklos, Ildiko Horvath
Summary: Oxidative stress driven by environmental and local airway factors is a significant contributor to chronic obstructive bronchiolitis, a key feature of COPD. The imbalance between oxidants and antioxidants amplifies local inflammation, worsens cardiovascular health, and contributes to COPD-related cardiovascular dysfunctions and mortality. This review provides an overview of recent advances in understanding the mechanisms and countermeasures of oxidative stress, with a focus on the interplay between local and systemic processes. It also introduces major regulatory mechanisms and suggests areas for further research in this field.
Review
Dermatology
Fumikazu Yamazaki
Summary: Psoriasis used to be considered a skin disease with complications related to diet and obesity, but it is now recognized as a systemic inflammatory disease with cytokines that can induce various other diseases. Individuals with psoriasis have higher incidences of cerebral and cardiovascular diseases and tend to die at a younger age. Clear guidelines have not yet been established for how much vascular lesion testing should be performed in patients with psoriasis.
JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Athanasios Voulgaris, Kostas Archontogeorgis, Athanasia Pataka, Alexandros N. Flaris, Paschalis Ntolios, Maria R. Bonsignore, Sophia Schiza, Paschalis Steiropoulos
Summary: This study investigated the prevalence of comorbidities in OS and OSAS patients, finding that OS patients exhibit more severe nocturnal hypoxia and impaired gas exchange in wakefulness, as well as a higher burden of cardiovascular disease compared to OSAS patients matched in sex, age, and BMI.
MEDICINA-LITHUANIA
(2021)
Review
Rheumatology
Hatice Bodur
Summary: In recent years, researchers have focused on the development of comorbidities associated with axial spondyloarthritis, such as hypertension, smoking, dyslipidemia, diabetes mellitus, obesity, and the presence of inflammation. Previous studies have shown that HLA-B27 could be a genetic risk factor for various cardiac conditions. Evaluating cardiovascular risks periodically and considering all risks and benefits in spondyloarthropathies is crucial in the treatment and follow-up of these patients.
CLINICAL RHEUMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Enrica Rossini, Federico Biscetti, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Maria Anna Nicolazzi, Marcello Covino, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: Atherosclerotic cardiovascular disease remains a leading cause of morbidity and mortality in high-income countries, although its impact is decreasing. Statins are effective in reducing LDL cholesterol and the risk of mortality, but are under-prescribed or under-dosed due to concerns about side effects. Personalized treatment decisions should be made based on individual considerations and shared decision-making.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Avonne E. Connor, Chester L. Schmaltz, Jeannette Jackson-Thompson, Kala Visvanathan
Summary: Women with coexisting comorbidities at the time of breast cancer diagnosis have an increased risk of breast cancer and overall mortality. Newly diagnosed comorbidities such as diabetes, hypertension, and CVD are associated with an increased risk of CVD mortality among breast cancer patients, especially those who receive chemotherapy. Monitoring for these conditions from the time of breast cancer diagnosis may help reduce CVD mortality.
Article
Multidisciplinary Sciences
Donato Lacedonia, Giulia Scioscia, Carla Santomasi, Paolo Fuso, Giovanna Elisiana Carpagnano, Andrea Portacci, Franco Mastroianni, Giovanni Larizza, Eugenio Sabato, Emanuela Profilo, Emanuela Resta, Maria Pia Foschino Barbaro, Onofrio Resta
Summary: This study found that the prevalence of COPD and current smokers among COVID-19 patients was not high, suggesting they were not at increased risk of infection. However, once infected, COPD patients and former smokers had the highest all-cause mortality, primarily due to the presence of comorbidities.
SCIENTIFIC REPORTS
(2021)
Review
Rheumatology
Jose M. Pego-Reigosa, Juliana Restrepo Velez, Chiara Baldini, Inigo Rua-Figueroa Fernandez de Larrinoa
Summary: Information about comorbidities in primary Sjogren's syndrome (pSS) is limited, but cardiovascular disease, infections, musculoskeletal conditions, and malignancy are likely the most relevant comorbid conditions in pSS. Infections such as oral candidal infections and fibromyalgia are common in daily practice, while incidences of cardiovascular events and cancer in pSS are relatively low compared to the general population. Early atherosclerosis has been found in pSS patients through different techniques, with a slightly increased risk of coronary events and malignancy in these patients.
Article
Biochemistry & Molecular Biology
Ankit Gupta, Roshan Mathew, Anjali Anand, Tanu Bhardwaj, Aakriti Singh, Krishna Singh, Amit Kumar, Prakash Ranjan Mishra, Tarun Kumar Sharma
Summary: Heart failure is a leading cause of death worldwide and there is a need for better biomarkers for risk stratification. Recent research has shown that sST2 has potential as a biomarker. In this study, an aptamer against sST2 was identified from an aptamer library and used to detect sST2 levels. The results suggest that a combination of aptamer and antibody-based assay can be used to design a rapid detection method for heart failure patients in emergency settings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Multidisciplinary Sciences
Frederik Trinkmann, Steffi A. Lenz, Julia Schafer, Joshua Gawlitza, Michele Schroeter, Tobias Gradinger, Ibrahim Akin, Martin Borggrefe, Thomas Ganslandt, Joachim Saur
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Joshua Gawlitza, Frederik Trinkmann, Franziska Trudzinski, Heinrike Wilkens, Arno Buecker, Jonas Stroeder, Peter Fries
Letter
Respiratory System
Frederik Trinkmann, Henrik Watz, Felix J. F. Herth
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Oncology
Stefan Stefanovic, Sebastian Berlit, Elena Sperk, Frederik Wenz, Christel Weiss, Frederik Trinkmann, Marc Suetterlin, Benjamin Tuschy
Summary: The study aimed to evaluate the acute cardiac toxicity caused by IORT in early breast cancer patients. The results showed no significant differences in troponin I levels between patients who received IORT during breast-conserving surgery and those who did not, suggesting IORT may not increase the risk of acute cardiac toxicity in these patients.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Medicine, General & Internal
Joshua Gawlitza, Thomas Henzler, Frederik Trinkmann, Elke Nekolla, Holger Haubenreisser, Gunnar Brix
Article
Respiratory System
Frederik Trinkmann, Mate Maros, Katharina Roth, Arne Hermanns, Julia Schaefer, Joshua Gawlitza, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Felix J. F. Herth, Thomas Ganslandt
Summary: The study found that age is the most important factor influencing SF6-MBW parameters, with a significant impact on global ventilation heterogeneity and acinar ventilation heterogeneity. Smoking has a minimal effect on the parameters. Height, weight, and sex do not appear to have an impact on the parameters.
Article
Multidisciplinary Sciences
Mate E. Maros, Chang Gyu Cho, Andreas G. Junge, Benedikt Kaempgen, Victor Saase, Fabian Siegel, Frederik Trinkmann, Thomas Ganslandt, Christoph Groden, Holger Wenz
Summary: The study compared the use of machine learning algorithms developed on manually and automatically extracted imaging features for improving radiology report quality, finding that SVMs and FastText performed well in recommending ASPECTS.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Frauke Pedersen, Frederik Trinkmann, Mustafa Abdo, Anne-Marie Kirsten, Klaus F. Rabe, Henrik Watz, Simonetta Baraldo, Marina Saetta, Jens M. Hohlfeld, Olaf Holz
Summary: The study examined the impact of sputum cell quality on soluble biomarker concentrations in sputum supernatant, revealing a significant influence on some biomarkers. Samples with higher cell quality showed less variability in protein concentrations compared to those with lower cell quality.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Allergy
Mustafa Abdo, Benjamin Waschki, Anne-Marie Kirsten, Frederik Trinkmann, Heike Biller, Christian Herzmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Thomas Bahmer, Henrik Watz
Summary: The study aimed to explore the impact of symptom control on physical activity and body composition in asthma patients. The results showed that patients with uncontrolled asthma had increased fat mass and decreased muscle mass compared to those with controlled asthma or healthy controls. Physical activity was found to be an independent predictor of body composition, with persistently uncontrolled asthma patients demonstrating sustained physical inactivity and adverse changes in body composition.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Article
Respiratory System
Mustafa Abdo, Henrik Watz, Vera Veith, Anne-Marie Kirsten, Heike Biller, Frauke Pedersen, Erika von Mutius, Matthias V. Kopp, Gesine Hansen, Benjamin Waschki, Klaus F. Rabe, Frederik Trinkmann, Thomas Bahmer
RESPIRATORY RESEARCH
(2020)
Meeting Abstract
Respiratory System
Frederik Trinkmann, Mate Maros, Katharina Roth, Arne Hermanns, Julia Schafer, Joshua Gawlitza, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Thomas Ganslandt, Felix Herth
EUROPEAN RESPIRATORY JOURNAL
(2020)
Meeting Abstract
Respiratory System
Frederik Trinkmann, Julia Schafer, Franziska Trudzinski, Joshua Gawlitza, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Thomas Ganslandt, Felix Herth, Roland Buhl
EUROPEAN RESPIRATORY JOURNAL
(2020)
Meeting Abstract
Respiratory System
Franziska Trudzinski, Claus F. Vogelmeier, Roland Buhl, Frederik Trinkmann, Victoria Obermoser, Peter Kardos, Carl-Peter Criee, Heinrich Worth
EUROPEAN RESPIRATORY JOURNAL
(2020)
Meeting Abstract
Respiratory System
F. Trinkmann, S. Lenz, J. Schaefer, J. Gawlitza, M. Schroeter, T. Gradinger, W. Dieker, I Akin, M. Borggrefe, T. Ganslandt, J. Saur
Meeting Abstract
Critical Care Medicine
F. Trinkmann, M. Maros, K. Roth, A. Hermanns, J. Schaefer, J. Gawlitza, J. Saur, I. Akin, M. Borggrefe, T. Ganslandt, F. J. Herth
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
