Article
Biochemical Research Methods
Silvia Noble Anbunesan, Alba Alfonso-Garcia, Xiangnan Zhou, Julien Bec, Han Sung Lee, Lee-Way Jin, Orin Bloch, Laura Marcu
Summary: Intraoperative identification of IDH-mutant glioma using fluorescence lifetime imaging can aid in modifying tumor resection strategies for better survival outcomes.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Neurosciences
Clement Brunner, Emilie Mace, Gabriel Montaldo, Alan Urban
Summary: Researchers have developed a directional flow filter to accurately measure red blood cell velocity (RBCv) in small cortical vessels using functional ultrasound imaging without contrast agents. They observed a significant increase in RBCv in vessels during forepaw stimulation, with higher RBCv in penetrating arterioles located in the center of the activated area.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yong Guo, Luwei Wang, Ziyi Luo, Yinru Zhu, Xinwei Gao, Xiaoyu Weng, Yiping Wang, Wei Yan, Junle Qu
Summary: Volumetric imaging of a mouse brain in vivo was conducted using one-photon and two-photon ultralong anti-diffracting (UAD) beam illumination. The 3D structure of blood vessels in the mouse brain was mapped to a 2D image. The use of two-photon UAD beam significantly improved imaging depth and signal-to-background ratio compared to one-photon UAD beam. Dynamic volumetric imaging of mouse brain blood vessels in vivo and blood flow velocity were successfully obtained using two-photon UAD volumetric imaging.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ferdinand Knieling, Robert Cesnjevar, Adrian P. Regensburger, Alexandra L. Wagner, Ariawan Purbojo, Sven Dittrich, Frank Munch, Antje Neubert, Joachim Woelfle, Jorg Jungert, Andre Ruffer
Summary: This study aimed to assess cerebral perfusion in neonates with transposition of the great arteries (TGA) undergoing arterial switch operation (ASO) using transfontanellar contrast-enhanced US (T-CEUS). The results revealed reduced cerebral perfusion in neonates under low-flow hypothermic conditions, which was inversely correlated with age at surgery.
Article
Engineering, Electrical & Electronic
Andrea Martinez-Lozano, Carolina Blanco-Angulo, Alberto Rodriguez-Martinez, Carlos G. Juan, Hector Garcia-Martinez, Jose M. Sabater-Navarro, Ernesto Avila-Navarro
Summary: This study demonstrates a radar-based microwave imaging system for detecting the brain-shift effect with minimal delay. The system estimates variations in the position and geometry of the brain to detect remarkable changes. Results show the potential of the system for intraoperative brain-shift detection.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Neurosciences
Bao-Yu Hsieh, Yu-Chieh Jill Kao, Ning Zhou, Yi-Pei Lin, Yu-Ying Mei, Sung-Yu Chu, Dong-Chuan Wu
Summary: The specific vascular dynamics of cerebral penetrating vessels during CSD and the potential different contributions of penetrating arterioles and venules to the CSD-related pathological vascular consequences were revealed. Using ultrasound dynamic ultrafast Doppler imaging to investigate CSD-induced cerebral vascular responses could help advance understanding of the mechanism of CSD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Constantin Roder, Patrick Haas, Marcos Tatagiba, Ulrike Ernemann, Benjamin Bender
Summary: The study aimed to analyze intraoperatively acquired DWI to identify susceptibility factors, compare with postoperative images, and improve technical aspects. In 78 patients, image quality was significantly worse intraoperatively compared to postoperative MRI due to air and artificial materials in the resection cavity and patient's head positioning. Frontal craniotomies had the highest risk of limited image quality among surgical approaches.
NEUROSURGICAL REVIEW
(2021)
Article
Medicine, Research & Experimental
Hyoung S. Lee, Sang G. Seo, Dong Y. Kim, Sung W. Kim, Young Choi, Kang D. Lee
Summary: The study evaluated the feasibility of using a single ipsilateral transcartilage needle electrode for intraoperative neuromonitoring during unilateral hemithyroidectomy. Results showed minimal complications, good nerve monitoring effects, and no risk of vocal cord paralysis.
Article
Biology
Kamila Wisniewska, Zbigniew Rybak, Maria Szymonowicz, Piotr Kuropka, Katarzyna Kaleta-Kuratewicz, Maciej Dobrzynski
Summary: Our study suggests a moderate correlation between pulp inflammation and the formation of new vessels, including lymphatic vessels. However, there is no conclusive evidence that lymphatic vessels can form systems within the dental pulp to facilitate drainage of the tooth cavity.
Article
Engineering, Biomedical
Alessa Hutfilz, Dirk Theisen-Kunde, Matteo Mario Bonsanto, Ralf Brinkmann
Summary: Infrared lasers like the thulium laser emitting at 1940 nm wavelength are suitable for coagulation in neurosurgery due to wavelength-specific water absorption. In comparison to bipolar forceps, pulsed thulium laser radiation achieved less-damaging blood vessel coagulation without tissue ablation. The pulsed laser application resulted in a blood vessel occlusion rate of 92%, with no occurrence of ablation.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Raquel Leon, Himar Fabelo, Samuel Ortega, Juan F. Pineiro, Adam Szolna, Maria Hernandez, Carlos Espino, Aruma J. O'Shanahan, David Carrera, Sara Bisshopp, Coralia Sosa, Mariano Marquez, Jesus Morera, Bernardino Clavo, Gustavo M. Callico
Summary: This research introduces a new methodology for fusing visible and near-infrared (VNIR) and near-infrared (NIR) hyperspectral data to delineate brain tumor tissue during neurosurgical procedures, which improves classification accuracy by up to 21% compared to the use of each data modality independently.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Christian Baker, Miguel Xochicale, Fang-Yu Lin, Sunish Mathews, Francois Joubert, Dzhoshkun I. I. Shakir, Richard Miles, Charles A. A. Mosse, Tianrui Zhao, Weidong Liang, Yada Kunpalin, Brian Dromey, Talisa Mistry, Neil J. J. Sebire, Edward Zhang, Sebastien Ourselin, Paul C. C. Beard, Anna L. L. David, Adrien E. E. Desjardins, Tom Vercauteren, Wenfeng Xia
Summary: Ultrasound needle tracking is an essential tool for minimally-invasive procedures. This study presents a new real-time ultrasound needle tracking system for guidance of fetal interventions, demonstrating its accuracy and clinical compatibility.
Article
Clinical Neurology
Luyuan Li, Kenji Ibayashi, Anthony Piscopo, Carolina Deifelt Streese, Haiming Chen, Jeremy D. W. Greenlee, David M. Hasan
Summary: This study investigated the feasibility of using WEB for evEEG and found that it is capable of capturing task-specific brain electrical activities. This suggests its potential in brain recording, stimulation, and brain-machine interface applications.
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Rob A. Vergeer, Mark R. Postma, Iris Schmidt, Astrid G. W. Korsten-Meijer, Robert A. Feijen, Schelto Kruijff, Wouter B. Nagengast, J. Marc C. van Dijk, Wilfred F. A. den Dunnen, Andre P. van Beek, Jos M. A. Kuijlen, Gerrit van den Berg
Summary: This study aims to determine the feasibility and dose-finding of intraoperative fluorescence imaging detection of PitNET tissue using VEGF-A targeting optical agent bevacizumab-800CW during endoscopic transsphenoidal surgery. Secondary objectives include identifying the optimal tracer dose for imaging, quantifying fluorescence intensity in vivo and ex vivo, correlating fluorescence signals with histopathological analysis, and assessing the (sub)cellular location of bevacizumab-800CW through fluorescence microscopy.
Article
Optics
Xu Sang, Bin Chen, Dong Li, Deqing Pan, Xuehao Sang
Summary: This paper presents a study on real-time monitoring of blood flow and thrombosis formation during laser surgery. It utilizes laser speckle contrast imaging (LSCI) technique combined with anisotropic diffusion filtering (ADF) to improve image quality and temporal resolution. The results show that the combination of tLSCI and ADF can effectively visualize laser-induced thrombus formation and vascular damage without the need for exogenous labels.
Article
Radiology, Nuclear Medicine & Medical Imaging
Glen Lo, Angela Jacques, Jan E. Dickinson
Summary: This study aimed to review the MRI appearances of the placenta in low-risk pregnancies. A total of 83 pregnancies were included in the analysis. The results demonstrated that placental thickness, T2 heterogeneity, and T2 dark bands varied with gestational age.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2023)
Article
Physiology
Michael J. Hackmann, John G. Elliot, Francis H. Y. Green, Alvenia Cairncross, Barry Cense, Robert A. McLaughlin, David Langton, Alan L. James, Peter B. Noble, Graham M. Donovan
Summary: This paper investigates the feasibility of quantifying airway wall thickness using PS-OCT technology in vivo, and analyzes the constraints that airway size poses to imaging techniques as well as the impact of physiological processes on measurements through the application of a mathematical model and human biobank data.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2022)
Article
Anesthesiology
Alexander J. T. Wood, Rashmi Rauniyar, Angela Jacques, Robert N. Palmer, Bradley Wibrow, Matthew H. Anstey
Summary: Vasopressor dependence is a common problem in critical illness recovery, and midodrine is often used off-label to expedite weaning. However, a case-control study showed that midodrine did not accelerate the weaning from vasopressor infusions in patients who had already received prolonged courses of these infusions.
ANAESTHESIA AND INTENSIVE CARE
(2023)
Review
Rehabilitation
Jane Hopkins, Keith Hill, Angela Jacques, Elissa Burton
Summary: This review study investigated the falls prevalence, falls risk factors, and the effectiveness of falls prevention interventions for community-dwelling individuals with Mild Cognitive Impairment. The findings revealed a high prevalence of falls, and identified several risk factors such as slow gait, dual-tasking, postural control, and non-amnesic Mild Cognitive Impairment. However, there were limited studies on falls prevention interventions, and no significant reduction in falls was observed. Best practice guidelines recommend balance training as a core component of falls prevention programs for older adults and people with Mild Cognitive Impairment.
CLINICAL REHABILITATION
(2023)
Article
Rehabilitation
Yoke Leng Ng, Keith D. Hill, Pazit Levinger, Angela Jacques, Elissa Burton
Summary: This study evaluated the feasibility of a multimodal exercise program conducted at a Seniors Exercise Park for older adults with mild balance dysfunction. The findings suggest that this program is feasible, safe, and improves physical and psychosocial health outcomes in older adults.
DISABILITY AND REHABILITATION
(2023)
Article
Emergency Medicine
Melinda Williamson, Annette Barton, Deborah Edwards, Claire Morrisby, Angela Jacques, Kristie J. Harper
Summary: The study aimed to assess the concordance between ED treatment for older adults who fall in Australia and falls prevention and management clinical guidelines. A retrospective audit of medical records revealed that assessment of cognition, medication review, and falls risk screening were commonly completed, while gait evaluation and vision review were less commonly documented. Compliance with guideline care recommendations was more likely among older patients with higher comorbidity levels, who required care assistance and received treatment from a multidisciplinary team in an observation ward.
AUSTRALASIAN EMERGENCY CARE
(2023)
Review
Clinical Neurology
Aden McLaughlin, Rahul Lakshmanan, Jason Dyke, Richard Warne, Snigdha Saha, Christopher Lind, Michael Bynevelt
Summary: Although paediatric brain tumours often occur in the posterior fossa, isolated diffuse gliomas in the cerebellum are extremely rare imaging findings. Only two cases of isolated diffuse paediatric cerebellar gliomas have been reported in English literature, and only one of these cases had similar imaging characteristics to our cases. These gliomas are distinct from other neoplastic entities in the paediatric posterior fossa, such as Lhermitte-Duclos. Clinical presentation and neurological examination are crucial in distinguishing these diffuse cerebellar pathologies from conditions like rhombencephalitis. This report presents two cases of diffuse cerebellar gliomas in children under 3 years old, with nearly identical imaging phenotypes but different histological and molecular genetic profiles.
CHILDS NERVOUS SYSTEM
(2023)
Article
Rehabilitation
Kristie J. Harper, Sian Fitzgerald, Png Xiyin, Jordan Kuzich, Soon Hui Leow, Angela Jacques, Courtenay Harris
Summary: Telehealth shows promising feasibility and clinical outcomes in occupational therapy hand and upper limb practice, with no significant increase in therapy time and referral time, and high patient satisfaction.
INTERNATIONAL JOURNAL OF TELEREHABILITATION
(2022)
Article
Health Care Sciences & Services
Jo-Aine Hang, Jacqueline Francis-Coad, Angela Jacques, Nicholas Waldron, Kate Purslowe, Anne-Marie Hill
Summary: This study aimed to compare changes in health-related outcomes between older adults participating in a facility-based transition care program (TCP) from admission to discharge, and between participants discharged home and those discharged to permanent residential care. The results showed that older adults participating in the TCP had significant improvements in activities of daily living, mobility, and health-related quality of life. However, participants discharged home still had mobility deficits and decreased instrumental activities of daily living compared to community level recommendations.
AUSTRALIAN HEALTH REVIEW
(2023)
Article
Rehabilitation
Jessica Nolan, Angela Jacques, Erin Godecke, Hiroaki Abe, Suzanne Babyar, Jeannine Bergmann, Melissa Birnbaum, Shenhao Dai, Cynthia Danells, Taiza G. S. Edwards, Marialuisa Gandolfi, Klaus Jahn, Ryan Koter, Avril Mansfield, Junji Nakamura, Vicky Pardo, Dominic Perennou, Celine Piscicelli, David Punt, Devra Romick-Sheldon, Wim Saeys, Nicola Smania, Nathalie Vaes, Abigail L. Whitt, Barbara Singer
Summary: This study aimed to provide consensus-based clinical practice recommendations for managing post-stroke lateropulsion using an international expert panel. After four rounds of surveys, a total of 119 recommendations for rehabilitation approaches and considerations were achieved. These recommendations can guide interventions for post-stroke lateropulsion.
CLINICAL REHABILITATION
(2023)
Article
Multidisciplinary Sciences
Jeffrey R. Cooley, Per Kjaer, Tue S. Jensen, Angela Jacques, Jean Theroux, Jeffrey J. Hebert
Summary: This study explores the associations between lumbar multifidus muscle quality and clinical outcomes relating to low back pain. The results indicate that higher lumbar multifidus muscle quality is associated with lower levels of low back pain-related disability and leg pain intensity, suggesting that muscle quality may play a role in the etiology of lumbar spine disorders.
Article
Biotechnology & Applied Microbiology
Nicholas Buckley, Paul Davey, Lynn Jensen, Kevin Baptist, Angela Jacques, Bas Jansen, Amity Campbell, Jenny Downs
Summary: This study aimed to compare the reliability of manually coded overnight videography and the XSENS DOT wearable sensor platform in assessing sleep biomechanics. The results showed that both methods demonstrated acceptable intra- and inter-rater reliability, providing confidence for their use in future sleep biomechanics studies.
BIOENGINEERING-BASEL
(2023)
Article
Public, Environmental & Occupational Health
Chiara Naseri, Janet Beilby, Sharmila Vaz, Angela Jacques, Dan Xu, Luke Garswood, Hilary O'Connell, Anne-Marie Hill
Summary: This study evaluated the effectiveness of a wellness program delivered from a community hub to address the wellness needs of older adults at risk of social isolation and declining physical activity. The findings showed that the program helped older adults increase their exercise duration and prioritize social connections.
PROGRESS IN COMMUNITY HEALTH PARTNERSHIPS-RESEARCH EDUCATION AND ACTION
(2023)
Article
Medicine, General & Internal
Liying Dai, Tashi Dorje, Jan Gootjes, Amit Shah, Lawrence Dembo, Jamie Rankin, Graham Hillis, Suzanne Robinson, John J. Atherton, Angela Jacques, Christopher M. Reid, Andrew Maiorana
Summary: This study aims to evaluate the effectiveness of a multifaceted intervention to support adherence to heart failure management guidelines in primary care. A randomised controlled trial will be conducted with 200 participants, assessing the prescription of five guideline-recommended treatments and various secondary outcomes. The results will be disseminated through peer-reviewed publications and conferences.
Meeting Abstract
Oncology
J. Ward, S. Gill, K. Armstrong, T. Fogarty, D. Tan, A. Scott, A. Yahya, S. Dhaliwal, A. Jacques, C. Tang
RADIOTHERAPY AND ONCOLOGY
(2022)
