Review
Pharmacology & Pharmacy
Zaid Sirhan, Rawan Alojair, Anita Thyagarajan, Ravi P. Sahu
Summary: Lung cancer is a major malignancy globally, with NSCLC being the most common type. PTEN, a tumor suppressor gene, plays a critical role in regulating cancer growth and its dysfunction is associated with poor prognosis in lung cancer patients. PTEN has been explored as a promising target for anti-cancer agents, as it can interact with multiple signaling pathways to devise effective treatment options for NSCLC.
Article
Oncology
Jhanelle Gray, Jeffrey C. Thompson, Erica L. Carpenter, Ehab Elkhouly, Charu Aggarwal
Summary: Plasma cfDNA genotyping is an alternative to tissue genotyping when tissue specimens are insufficient. It has become a standard-of-care tool in NSCLC, aiding in personalized treatment and potentially expanding to early cancer detection, monitoring therapy response, detecting minimal residual disease, and measuring tumor mutational burden.
Article
Biochemistry & Molecular Biology
Meina Wang, Roy S. Herbst, Chris Boshoff
Summary: Over the past two decades, molecular targeted therapies and immunotherapies have significantly improved outcomes for non-small-cell lung cancer (NSCLC), but the majority of advanced NSCLCs eventually become resistant. The future challenge lies in the application of predictive biomarkers for patient stratification in order to better manage NSCLC.
Review
Pharmacology & Pharmacy
Wenxiao Jiang, Guiqing Cai, Peter Hu, Yue Wang
Summary: Non-small cell lung cancer is recognized as one of the deadliest cancers globally, driven by smoking and air pollution. With the advancement of personalized medicine, physicians are increasingly aware of how to more effectively use anti-cancer agents.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Oncology
Fabrice Barlesi, Pascale Tomasini, Maryam Karimi, Stefan Michiels, Judith Raimbourg, Catherine Daniel, Henri Janicot, Anne Madroszyk, Clarisse Audigier-Valette, Elisabeth Quoix, Julien Mazieres, Denis Moro-Sibilot, Eric Dansin, Olivier Molinier, Hugues Morel, Eric Pichon, Alexis Cortot, Josiane Otto, Francois Chomy, Pierre-Jean Souquet, Nicolas Cloarec, Etienne Giroux-Leprieur, Ivan Bieche, Ludovic Lacroix, Sandrine Boyault, Valery Attignon, Isabelle Soubeyran, Alain Morel, Alicia Tran-Dien, Alexandra Jacquet, Filippo Gustavo Dall'Olio, Marta Jimenez, Jean-Charles Soria, Benjamin Besse
Summary: Targeted therapies and immune checkpoint blockers have revolutionized the treatment of non-small cell lung cancer. This study investigated the use of targeted therapies and immune checkpoint blockers as maintenance therapy based on molecular characterization. The results showed no significant differences in progression-free survival between targeted therapies and standard-of-care, and immune checkpoint blockers showed enhanced benefits in patients with PD-L1 >= 1%.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Cian O'Leary, Grace Murphy, Yong Yeung, Ming Tang, Vikram Jain, Connor G. O'Leary
Summary: Non-small-cell lung cancer (NSCLC) is a common and often fatal malignancy, with Kirsten rat sarcoma virus (KRAS) mutation being a commonly mutated oncogene in NSCLC. Recently developed KRAS G12C inhibitors have overcome the therapeutic hurdle of targeting KRAS mutations. While these medications show substantial response rates in heavily pre-treated NSCLC patients, phase-3 evidence has not yet demonstrated an overall survival benefit compared to standard-of-care chemotherapy. Additionally, these medications may have a negative interaction with immunotherapies, leading to higher hepatotoxicity rates. Despite these limitations, these medications represent an important advancement in targeted and personalized oncological treatment, and future trials may provide further meaningful outcomes for guiding treatment in this patient cohort.
Review
Oncology
Paz J. Vellanki, Flora Mulkey, Adnan A. Jaigirdar, Lisa Rodriguez, Yibo Wang, Yuan Xu, Hong Zhao, Jiang Liu, Grant Howe, Jian Wang, Qiuyi Choo, Sarah J. Golding, Victoria Mansell, Kwadwo Korsah, Dianne Spillman, R. Angelo de Claro, Richard Pazdur, Julia A. Beaver, Harpreet Singh
Summary: On May 26, 2020, FDA approved nivolumab with ipilimumab and two cycles of platinum-doublet chemotherapy as a first-line treatment for metastatic or recurrent non-small cell lung cancer patients, improving overall survival. This approval was based on the results of an open-label trial, demonstrating significant improvements in overall survival, progression-free survival, and overall response rate for patients receiving this combination therapy.
CLINICAL CANCER RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, Xue-Qing Zhang
Summary: A noninvasive aerosol inhalation nanoparticle system has been developed for the treatment of KRAS-mutant non-small-cell lung cancer (NSCLC). The inhalable nanoparticles show effective tumor targeting and enhanced antitumor activity in a mouse model. Compared to systemic delivery, the nebulized nanoparticles demonstrate better biosafety and present a promising gene therapy approach for KRAS-mutant NSCLC and other respiratory diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Oncology
Mark M. Awad, Ramaswamy Govindan, Kristen N. Balogh, David R. Spigel, Edward B. Garon, Meghan E. Bushway, Asaf Poran, Joong Hyuk Sheen, Victoria Kohler, Ekaterina Esaulova, John Srouji, Suchitra Ramesh, Rohit Vyasamneni, Binisha Karki, Tracey E. Sciuto, Himanshu Sethi, Jesse Z. Dong, Melissa A. Moles, Kelledy Manson, Michael S. Rooney, Zakaria S. Khondker, Mark DeMario, Richard B. Gaynor, Lakshmi Srinivasan
Summary: Neoantigens derived from tumor DNA mutations can be targeted for immune-based therapy. This study presents the clinical and immune data from a Phase lb clinical trial investigating a personalized neoantigen vaccine NEO-PV-01 in combination with other drugs for first-line treatment of advanced non-squamous non-small cell lung cancer (NSCLC). The analysis of 38 patients showed that this regimen is safe and has immunogenicity.
Review
Oncology
Jamie E. Chaft, Andreas Rimner, Walter Weder, Christopher G. Azzoli, Mark G. Kris, Tina Cascone
Summary: The treatment goal for early-stage lung cancer patients is cure, with surgical resection or radiotherapy as definitive local treatments along with adjuvant therapy to improve the likelihood of cure. New therapies lag behind due to inefficient trial designs and lengthy follow-ups, despite efforts to study surrogate endpoints to shorten trial durations.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Joshua R. Veatch, Sylvain Simon, Stanley R. Riddell
Summary: Preliminary results from a phase 1 trial suggest promising anti-tumor activity of tumor-infiltrating-lymphocyte therapy in patients with advanced non-small-cell lung cancer.
Article
Engineering, Biomedical
Yu Wang, Yan Tang, Xiao-mei Zhao, Gui Huang, Jin-hong Gong, Shu-di Yang, Hui Li, Wen-jun Wan, Chang-hao Jia, Gang Chen, Xue-nong Zhang
Summary: In this study, a multifunctional non-viral vector was constructed for efficient delivery of CRISPR/Cas9 plasmid. The vector actively targeted tumor cells and delivered the cargo into cell nuclei, resulting in genome editing effects. By disrupting the MTH1 gene, the growth of non-small cell lung cancer was inhibited, promoting cell apoptosis in tumor tissue and reducing liver metastasis.
ACTA BIOMATERIALIA
(2022)
Article
Multidisciplinary Sciences
Li Ming Wang, Ranjan Yadav, Monica Serban, Osvaldo Arias, Jan Seuntjens, Norma Ybarra
Summary: This study established orthotopic mice models with treatable tumors through implantation of lung cancer cells in the left or right lung. The results showed that a single 20 Gy dose of radiation therapy achieved similar tumor control and survival outcomes in both left and right lung tumors.
Review
Oncology
Qianqian Guo, Liwei Liu, Zelong Chen, Yannan Fan, Yang Zhou, Ziqiao Yuan, Wenzhou Zhang
Summary: Despite advancements in diagnosis and treatment, lung cancer mortality remains high. This review provides an overview of current diagnostic methods and therapies for non-small cell lung cancer, serving as a guide for clinicians.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Yajing Wu, Vivek Verma, Fei Liang, Qiang Lin, Zhiguo Zhou, Zhiyu Wang, Yi Wang, Jun Wang, Joe Y. Chang
Summary: A systematic review with a meta-analysis comparing local consolidative therapy (LCT) and systemic therapy alone for metastatic non-small cell lung cancer (mNSCLC) showed that LCT may improve progression-free survival (PFS) and overall survival (OS) without increasing the risk of high-grade adverse events (AEs). However, further research is needed, specifically for polymetastatic mNSCLC, and the findings cannot be generalized to other histologies.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Akash Patel, Leonid Roshkovan, Sally McNulty, Evan Alley, Drew A. Torigian, Arun C. Nachiappan, Maya Galperin-Aizenberg, Eduardo M. Barbosa, Joseph DiRienzi, Ian Berger, Urooj Khalid, Andrew R. Haas, Sunil Singhal, E. Paul Wileyto, Keith A. Cengel, Sharyn I. Katz
Summary: The study demonstrates that by increasing the time delay for imaging acquisition after intravenous contrast administration, improved tumor enhancement and conspicuity is achieved. The data support further research on delayed phase contrast CT imaging in MPM.
CLINICAL LUNG CANCER
(2021)
Article
Oncology
Sharyn Katz, Leonid Roshkovan, Ian Berger, Joseph S. Friedberg, Evan W. Alley, Charles B. Simone, Andrew R. Haas, Keith A. Cengel, Daniel H. Sterman, Steven M. Albelda
Summary: Serum levels of SMRP and fibulin-3 show correlation with tumor volume in malignant pleural mesothelioma, but are not useful in predicting tumor response in immunogene therapy trial.
Article
Oncology
I. Berger, Scott Simpson, JS. Friedberg, Melissa J. Culligan, E. Paul Wileyto, Evan W. Alley, D. Sterman, Akash M. Patel, U. Khalid, C. B. Simone, Keith A. Cengel, Sharyn I. Katz, L. Roshkovan
Summary: This study aimed to determine if MPM PILN metastasis can be reliably detected on CT. The results showed that CT does not reliably identify metastatic PILN in MPM patients undergoing eP/D.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah P. Thomas, Ramie Fathy, Savannah Aepli, Caitlin B. Clancy, Gregg Y. Lipschik, Scott A. Simpson, Sharyn I. Katz, Robert W. Doms, Arun C. Nachiappan
Summary: This study compared the effectiveness of the Choose Your Own Adventure (CYOA) presentation format and the linear case format in teaching radiology small group sessions to medical students. The results showed that students in the CYOA format group reported higher engagement, satisfaction, and enhanced clinical decision making skills.
ACADEMIC RADIOLOGY
(2022)
Article
Dermatology
Qisi Sun, Nareh M. Burgren, Shayan Cheraghlou, Amy S. Paller, Margarita Larralde, Lionel Bercovitch, Jonathan Levinsohn, Ivy Ren, Rong Hua Hu, Jing Zhou, Theodore Zaki, Ryan Fan, Charlie Tian, Corey Saraceni, Carol J. Nelson-Williams, Erin Loring, Brittany G. Craiglow, Leonard M. Milstone, Richard P. Lifton, Lynn M. Boyden, Keith A. Choate
Summary: This study recruited an international group of individuals with ichthyosis to expand the genotypic and phenotypic spectrum of the disease and establish associations between clinical manifestations and genotypes.
Letter
Dermatology
Ryan Fan, Audrey C. Leasure, William Damsky, Jeffrey M. Cohen
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Hannah Horng, Apurva Singh, Bardia Yousefi, Eric A. Cohen, Babak Haghighi, Sharyn Katz, Peter B. Noel, Russell T. Shinohara, Despina Kontos
Summary: Radiomic features have a wide range of clinical applications, but their performance can be affected by variability due to image acquisition factors. This study proposes two methods for addressing these limitations, including a sequential method and a Gaussian Mixture Model-based method. The methods were evaluated on lung computed tomography datasets and demonstrated improved harmonization performance and similar survival analysis results.
SCIENTIFIC REPORTS
(2022)
Letter
Dermatology
Ryan Fan, Audrey C. Leasure, Fahrisa I. Maisha, Jeffrey M. Cohen, Alicia J. Little
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Apurva Singh, Hannah Horng, Leonid Roshkovan, Joanna K. Weeks, Michelle Hershman, Peter Noel, Jose Marcio Luna, Eric A. Cohen, Lauren Pantalone, Russell T. Shinohara, Joshua M. Bauml, Jeffrey C. Thompson, Charu Aggarwal, Erica L. Carpenter, Sharyn Katz, Despina Kontos
Summary: In this study, we aimed to determine the feasibility of a novel radiomic biomarker that can predict progression-free survival (PFS) in non-small cell lung cancer (NSCLC) patients undergoing immunotherapy. We analyzed data from 107 NSCLC patients treated with pembrolizumab-based therapy and used various software and techniques to extract radiomic features and harmonize the data. Our findings suggest that the integration of radiomic phenotypes with clinical factors improves the prediction of PFS in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Ryan Fan, Audrey C. Leasure, William Damsky, Jeffrey M. Cohen
Summary: This cross-sectional study examined the association between atopic dermatitis (AD) and migraine among a cohort of US adults. The study found that adults with AD were 89% more likely to have a diagnosis of migraine after controlling for common comorbidities.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Dermatology
Christine Hodelin, Ryan Fan, William Damsky, Jeffrey M. M. Cohen
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Ryan Fan, Catherine Baker, Earl J. Glusac, Mina L. Xu, Alejandro A. Gru, Jeffrey M. Cohen
Summary: Primary, acute Epstein-Barr virus (EBV) infection can cause various skin eruptions, including viral exanthem and erythema multiforme. Chronic latent EBV infection rarely leads to lymphoproliferative disorders with cutaneous manifestations, but these disorders do not arise from primary infection. This report presents a case of primary, acute EBV infection with histopathologic features closely resembling aggressive cytotoxic cutaneous T-cell lymphoma.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Ali A. Saifuddin, Austin L. Chien, Kumar M. Shah, Leonard Bodner, John Nosher, Francis Kang
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Letter
Dermatology
Gloria F. Chen, Ryan Fan, Audrey C. Leasure, Daniel F. Levey, William Damsky, Jeffrey M. Cohen
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cathal O'Leary, Maxim Itkin, Leonid Roshkovan, Sharyn Katz, Quy Cao, Michelle Hershman, Maya Galperin-Aizenberg
Summary: This study aimed to distinguish the CT patterns of lymphatic and nonlymphatic causes of plastic bronchitis (PB) through comparison with lymphatic imaging. Ground-glass opacity (GGO) was found to be more frequently observed in patients with lymphatic PB than in those with nonlymphatic PB, and its location correlated with lymphatic imaging and bronchoscopic findings.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2022)