Article
Behavioral Sciences
Cathrine Hultman, Nikita Tjernstrom, Sofia Vadlin, Mattias Rehn, Kent W. Nilsson, Erika Roman, Cecilia Aslund
Summary: Decision-making requires individuals to perceive probabilities and risks. This study explores decision-making strategies among young adults and adult rats, and compares the similarities and differences in their choices.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Guy A. Higgins, Matt Brown, Cam MacMillan, Leo B. Silenieks, Sandy Thevarkunnel
Summary: In this study, the effects of AMP and ATX were compared in different tasks, with ATX showing a reducing effect on impulsive behavior but no significant impact on impulsive choice and risky decision making, while AMP affecting choice preference and discounting, but in a nuanced manner.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Clinical Neurology
Lidia Cabeza, Bahrie Ramadan, Julie Giustiniani, Christophe Houdayer, Yann Pellequer, Damien Gabriel, Sylvie Fauconnet, Emmanuel Haffen, Pierre-Yves Risold, Dominique Fellmann, David Belin, Yvan Peterschmitt
Summary: The study demonstrates that chronic exposure to glucocorticoids induces suboptimal decision making in uncertain environments, impairs spatial working memory, and affects motor learning processes. Neurobiological analysis shows that glucocorticoid receptor expression is downregulated in the medial prefrontal cortex of individuals exposed to cortisol, which negatively correlates with their decision making performance.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Sarah E. Nigro, Minjie Wu, Anthony C. Juliano, Brendan Flynn, Lisa H. Lu, Alan L. Landay, Audrey L. French, Shaolin Yang
Summary: The study found that cocaine dependence significantly impacted overall IGT performance. Individuals who were HIV-positive tended to have less total money at the end of the game, indicating a focus on short-term gains rather than long-term rewards.
JOURNAL OF NEUROVIROLOGY
(2021)
Article
Multidisciplinary Sciences
Celia C. Beron, Shay Q. Neufeld, Scott W. Linderman, Bernardo L. Sabatini
Summary: In probabilistic and nonstationary environments, mice use internal and external cues to make decisions. The behavior of mice in a task with time-varying reward probabilities is both deterministic and stochastic. Modeling their behavior through equivalent models reveals that mice achieve near-maximal reward rates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Paul Theo Zebhauser, Ana Macchia, Edward Gold, Stephanie Salcedo, Bethany Burum, Miguel Alonso-Alonso, Daniel T. Gilbert, Alvaro Pascual-Leone, Anna-Katharine Brem
Summary: Oxytocin has been extensively studied for its effects on socio-cognitive and behavioral functions, but limited evidence exists regarding its effects on non-social cognition and decision-making. This study found that intranasal administration of 24 IU oxytocin had detrimental effects on decision-making under low outcome predictability/high ambiguity, leading to riskier performance. In contrast, oxytocin resulted in slightly less risky decisions under high outcome probability/low ambiguity. These findings suggest that oxytocin may influence decision-making in healthy males, depending on contextual information.
Review
Behavioral Sciences
Aina Sastre-Buades, Adrian Alacreu-Crespo, Philippe Courtet, Enrique Baca-Garcia, Maria Luisa Barrigon
Summary: Studies show that individuals who have attempted suicide exhibit deficits in decision-making, specifically performing worse under conditions of risk. These impairments in decision-making are independent of age, gender, and psychiatric disorders, indicating they may be considered a cognitive trait of suicidal vulnerability.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Chi Ieong Lau, Wei-Hung Chen, Han-Cheng Wang, Vincent Walsh
Summary: This study aimed to investigate the decision-making deficit in patients with chronic migraine and medication overuse headache (CM + MOH). The results showed that CM + MOH patients made more disadvantageous decisions under ambiguous conditions. This suggests that decision-making may be related to MOH.
Article
Psychology, Multidisciplinary
Brian F. O'Donnell, Patrick D. Skosnik, William P. Hetrick, Daniel J. Fridberg
Summary: Chronic cannabis users showed impairments in decision making tasks compared to non-users, displaying a preference for immediate rewards, less advantageous decisions, and greater impulsivity. However, both groups had similar performance on the Probabilistic Reversal Learning Task.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychiatry
Dandan Li, Fengyan Zhang, Lu Wang, Yifan Zhang, Tingting Yang, Kai Wang, Chunyan Zhu
Summary: This study found that patients with adolescent-onset schizophrenia (AOS) exhibit impaired decision-making, particularly under risky conditions, and have difficulties with executive function. This suggests a specific pattern of decision-making deficits in AOS, emphasizing the importance of considering risk-taking behaviors and executive functions in this population.
Article
Computer Science, Artificial Intelligence
J. Ignacio Serrano, Angel Iglesias, Steven P. Woods, M. Dolores del Castillo
Summary: This study examines a novel computational cognitive model of the Iowa Gambling Task (IGT) that captures fine-grained differences in decision-making styles in individuals with recent methamphetamine use disorders. The models generated from the study are more sensitive than traditional metrics in detecting risky decision-making behaviors in persons with methamphetamine use disorders. Methamphetamine users exhibit lower estimation of possible losses and associated risk, while multi-substance users show behavior patterns that affect the evaluation of losses and the risk associated with gains.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Behavioral Sciences
Magdalen G. Schluter, David C. Hodgins
Summary: The study suggests a potential maintaining role of probabilistic discounting in gambling disorder, but does not support a maintaining role for delay discounting.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Marina Cosenza, Maria Ciccarelli, Olimpia Matarazzo, Mark D. D. Griffiths, Giovanna Nigro
Summary: Through snowball sampling, this study found that temporal perspective, gambling-related cognitions, and future orientation can predict decision-making performance in affective decision-making. These findings suggest that individual characteristics should be considered in the clinical evaluation of decision-making performance.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Psychiatry
Laura Di Lodovico, Audrey Versini, Mathieu Lachatre, Jacopo Marcheselli, Nicolas Ramoz, Philip Gorwood
Summary: This study aimed to determine the endophenotypic, state- or trait-associated nature of decision-making impairment in patients with anorexia nervosa. The findings suggest that altered decision-making ability in AN is not an endophenotypic trait, but a state-associated characteristic resulting from the interplay between trait-associated low feedback sensitivity and state-associated features of the disease.
EUROPEAN PSYCHIATRY
(2022)
Article
Psychiatry
Myung Ji Kwak, Wha Young Kim, Seung-Hyun Jung, Yeun-Jun Chung, Jeong-Hoon Kim
Summary: Through studying the decision-making ability of rats, we found differential gene expression profiles in the mPFC and NAc between risk-seeking and risk-averse rats, providing insights into the transcriptional components underlying this process.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2022)
Article
Biochemistry & Molecular Biology
Hyung Shin Yoon, Min Jeong Ku, Wen Ting Cai, Jeong-Hoon Kim
NEUROCHEMISTRY INTERNATIONAL
(2019)
Article
Pharmacology & Pharmacy
Wen Ting Cai, Joonyeup Han, Wha Young Kim, Jeong-Hoon Kim
Summary: The study utilized immunohistochemistry to validate changes in AMPA receptor expression levels in the NAcc after cocaine exposure. The results showed that cocaine significantly increased the immunofluorescence intensity of GluA1, leading to locomotor sensitization.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Choong Yeon Kim, Min Jeong Ku, Raza Qazi, Hong Jae Nam, Jong Woo Park, Kum Seok Nam, Shane Oh, Inho Kang, Jae-Hyung Jang, Wha Young Kim, Jeong-Hoon Kim, Jae-Woong Jeong
Summary: Optogenetic techniques allow precise manipulation of neuronal activity for neural circuit dissection and therapeutic interventions. Recent advances in wireless optogenetics technology have enabled investigation of brain circuits in more natural conditions. However, existing wireless implants still have limitations in terms of power requirements. A newly developed fully implantable optogenetic system allows intervention-free wireless charging and control for operation in any environment.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Wen Ting Cai, Wha Young Kim, Myung Ji Kwak, Haeun Rim, Seung Eun Lee, Lars Bjorn Riecken, Helen Morrison, Jeong-Hoon Kim
Summary: Repeated injections of psychomotor stimulants can induce behavioral sensitization and lead to addictive behaviors. This study found that a specific mutant can inhibit the development of sensitization, providing important clues for understanding the role of dendritic spines in psychomotor stimulant addiction.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Joong-Keun Shin, Wha Young Kim, Haeun Rim, Jeong-Hoon Kim
Summary: Phosphorylation levels of GSK3I3 play differential roles in psychomotor stimulant-induced locomotor activity and conditioned locomotor activity. Treatment with GSK3I3 inhibitor lithium chloride can normalize these effects.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2022)
Article
Psychiatry
Myung Ji Kwak, Wha Young Kim, Seung-Hyun Jung, Yeun-Jun Chung, Jeong-Hoon Kim
Summary: Through studying the decision-making ability of rats, we found differential gene expression profiles in the mPFC and NAc between risk-seeking and risk-averse rats, providing insights into the transcriptional components underlying this process.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2022)
Article
Biochemistry & Molecular Biology
Bo Ram Cho, Wha Young Kim, Ju Kyong Jang, Jung Won Lee, Jeong-Hoon Kim
Summary: Microinjection of CART peptide 55-102 into the NAcc core attenuates psychostimulant-induced locomotor activity. The negative regulatory role of the CART peptide is mediated by normalizing the changes in phosphorylation levels of Akt-GSK3 beta and GluA1 modified by AMPH at this site.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Wha Young Kim, Wen Ting Cai, Ju Kyong Jang, Jeong-Hoon Kim
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2020)