Article
Clinical Neurology
Karolina Noworyta, Rafal Rygula
Summary: This study investigates how individual trait sensitivity to reinforcement affects the reactivity of rats to acute antidepressant treatment, revealing that different types of reinforcement sensitivity may lead to different vulnerabilities to mood disorders.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Yi-han Sheu, Colin Magdamo, Matthew Miller, Sudeshna Das, Deborah Blacker, Jordan W. W. Smoller
Summary: This study used electronic health record (EHR) data and artificial intelligence (AI) to predict the effectiveness of antidepressant drugs. The models trained showed good prediction performance and could accurately predict the response to antidepressants. The study demonstrated that real-world EHR data and AI modeling can accurately predict antidepressant response, providing insights for the further development of clinical decision support systems.
NPJ DIGITAL MEDICINE
(2023)
Article
Psychiatry
Mark M. Gergues, Christine N. Yohn, Anusha Bharadia, Marjorie R. Levinstein, Benjamin Adam Samuels
Summary: This study developed a method to assess treatment resistance in mice to antidepressants, revealing differences in expression of Activin signaling-related genes in the dentate gyrus (DG) between responders and non-responders to fluoxetine treatment. The findings suggest that targeted manipulations of DG can modify the behavioral response to fluoxetine bidirectionally, offering a new therapeutic avenue for more effective antidepressant treatments.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Cell Biology
Rajeev K. Singla, Shikha Joon, Li Shen, Bairong Shen
Summary: Depression is a neurological disorder and the fourth leading cause of long-term disability in humans. Natural products have shown potential in treating depression and its associated ailments. Translational informatics research utilizes informatics models to facilitate the translation of basic research to clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Cecilie Bay-Richter, Gregers Wegener
Summary: In recent years, there has been significant focus on the neuroimmune mechanisms of depression. This article systematically reviews the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on depressive-like behavior in rodent models of depression. The results suggest that stress models are the best choice for examining the antidepressant effects of NSAIDs, and rat models show a more homogeneous response compared to mouse models.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hao Wang, Jonathan L. Robinson, Pinar Kocabas, Johan Gustafsson, Mihail Anton, Pierre-Etienne Cholley, Shan Huang, Johan Gobom, Thomas Svensson, Mattias Uhlen, Henrik Zetterberg, Jens Nielsen
Summary: Genome-scale metabolic models (GEMs) are extensively used for analyzing mechanisms of human diseases and metabolic disorders. A unified platform of GEMs covering five major model animals was presented, providing comprehensive metabolic network coverage and revealing a potential biomarker for early diagnosis of Alzheimer's disease through integrative analysis of RNA-sequencing and proteomics data.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Tiziana Mundula, Simone Baldi, Elisabetta Gerace, Amedeo Amedei
Summary: A major depressive disorder is a severe mental illness that affects millions of people worldwide, characterized by a pervasive low mood that negatively impacts personal life, work life, or education. The most common and effective treatments consist of a multi-therapy approach, including psychological, social, and pharmacological support with antidepressant drugs. Recent evidence highlights the crucial role of gut microbiota in the regulation of antidepressant drug metabolism and activity, leading to the emergence of the field of pharmacomicrobiomics. This review aims to summarize the contribution of gut microbiota and its metabolites in depression, paving the way for personalized administration of antidepressant therapies.
Article
Biotechnology & Applied Microbiology
Erik A. Gonzalez-Leon, Jerry C. Hu, Kyriacos A. Athanasiou
Summary: This study extensively characterized the structural and functional properties of the medial and lateral Yucatan minipig knee menisci. The findings revealed similarities between the minipig and human menisci, supporting the use of minipigs as preclinical models for meniscal therapies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rene Rissel, Moritz Gosling, Jens Kamuf, Miriam Renz, Robert Ruemmler, Alexander Ziebart, Erik K. Hartmann
Summary: In a new experimental porcine model of ARDS, intravenous administration of levosimendan improved hemodynamics and lung function, but did not show significant beneficial effects on the inflammatory response and lung injury.
Review
Pharmacology & Pharmacy
Shimeng Lv, Guangheng Zhang, Yufei Huang, Jiamin Li, Ni Yang, Yitong Lu, Haoteng Ma, Yuexiang Ma, Jing Teng
Summary: This article summarizes the pharmacological mechanisms of antidepressants via regulating autophagy, discusses the potential of traditional Chinese medicine in depression treatment, and proposes new research strategies for basic research and clinical application.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Clinical Neurology
Shakila Meshkat, Roger C. Ho, Bing Cao, Kayla M. Teopiz, Joshua D. Rosenblat, Taeho Greg Rhee, Joshua D. Di Vincenzo, Felicia Ceban, Muhammad Youshay Jawad, Roger S. McIntyre
Summary: Ketamine, a NMDA receptor antagonist, has rapid acting antidepressant effect with high efficacy. However, not all patients respond to ketamine and some may even experience symptom deterioration. The discovery of repeatable and mechanistically relevant biomarkers is needed for treatment response prediction.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Yamina El Hamdaoui, Fang Zheng, Nikolas Fritz, Lian Ye, Mai Anh Tran, Kevin Schwickert, Tanja Schirmeister, Albert Braeuning, Dajana Lichtenstein, Ute A. Hellmich, Dorothee Weikert, Markus Heinrich, Giulia Treccani, Michael K. E. Schaefer, Gabriel Nowak, Bernd Nuernberg, Christian Alzheimer, Christian P. Mueller, Kristina Friedland
Summary: This study identifies TRPC6 channel as a druggable target for controlling anxious and depressive behavior and demonstrates the antidepressant action of hyperforin through the activation of this channel. The researchers synthesized a hyperforin analog, Hyp13, which shows similar binding and anxiolytic and antidepressant effects without inducing drug-drug interactions.
MOLECULAR PSYCHIATRY
(2022)
Review
Neurosciences
Garikoitz Azkona, Rosario Sanchez-Pernaute
Summary: Animal models are crucial in neuroscience research, but there are recurring issues in data collection and interpretation, a lack of biomarkers, and an over-reliance on mice, leading to low translation efficiency. Non-human primates, with their higher brain complexity and similarity to humans, can provide more relevant translational information. Therefore, resources for training, education, husbandry, and data sharing should be prioritized to improve translational efficiency.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Baomei Xia, Chang Chen, Weiwei Tao
Summary: Traditional Chinese medicine provides alternative strategies for treating depression, with Chinese herbal medicine as the major form of prescription. Many Chinese herbs have been shown to possess significant antidepressant properties, with mechanisms involving neuroplasticity improvements. This review examines the neuroplastic mechanisms underlying the antidepressant actions of Chinese herbal medicine and aims to offer a better understanding of the efficacy of TCM in treating depression.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Pharmacology & Pharmacy
Jan Engelmann, Stefanie Wagner, Andreas Solheid, David P. Herzog, Nadine Dreimueller, Marianne B. Mueller, Andre Tadic, Christoph Hiemke, Klaus Lieb
Summary: Switching antidepressants during a depressive episode may lead to an increase in adverse drug reactions, but high doses of antidepressants can significantly improve depressive symptoms and reduce adverse reactions. Therapeutic drug monitoring is recommended to guide therapy and manage tolerability issues associated with antidepressant treatment.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Tanja Jene, Inigo Ruiz de Azua, Annika Hasch, Jennifer Kluepfel, Julia Deuster, Mirjam Maas, Cora H. Nijboer, Beat Lutz, Marianne B. Mueller, Michael A. van der Kooij
Summary: Stress plays a significant role in modulating metabolism, yet chronic stress can alleviate the metabolic dysregulation caused by a high-fat diet. The study showed that stressed mice exhibited improved metabolic outcomes when exposed to a high-fat diet, indicating a potential benefit of comfort food during stress in reducing metabolic demands.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Neurosciences
Marija Milic, Ulrich Schmitt, Beat Lutz, Marianne B. Mueller
Summary: The study investigated whether baseline individual characteristics of male C57BL/6J mice could predict the resilient outcome after chronic social defeat (CSD). The results showed significant differences in exploration levels, approach to novelty, and avoidance of harm between resilient and susceptible mice. Before the stress, resilient mice demonstrated higher exploratory drive and approach to novel environments, while susceptible mice showed better performance in avoiding potential adversity.
NEUROBIOLOGY OF STRESS
(2021)
Article
Endocrinology & Metabolism
Malena Dos Santos Guilherme, Theodora Tsoutsouli, Monika Chanu Chongtham, Jennifer Winter, Susanne Gerber, Marianne B. Mueller, Kristina Endres
Summary: Prolonged social stress is a major cause for depression and pathophysiological changes. The chronic social defeat paradigm in mice is commonly used to study this stress. However, it is limited to males and involves physical stress. Expanding models to females is desirable as the prevalence of depression is higher in women. The social instability model was tested in female mice and resulted in elevated corticosterone levels and long-term effects such as increased body weight and fat deposits. Resilience in the model was associated with upregulated neurotrophic factor artemin.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Psychiatry
Jan Engelmann, Harald Murck, Stefanie Wagner, Lea Zillich, Fabian Streit, David P. Herzog, Dieter F. Braus, Andre Tadic, Klaus Lieb, Marianne B. Muller
Summary: This study investigated the predictive value of peripheral markers related to the mineralocorticoid receptor (MR) for the outcome of antidepressant treatment. The results showed that patients with more severe depression had lower blood pressure, lower K+ levels, and higher Na+/K+ ratios. These biomarkers obtained in routine clinical settings may be useful for risk stratification in early stages of depression treatment.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Microbiology
Malena dos Santos Guilherme, Francesco Valeri, Jennifer Winter, Marianne B. Mueller, Andreas Schwiertz, Kristina Endres
Summary: The microbiome plays an important role in resilience but does not directly influence stress susceptibility. However, it does affect the composition of the microbiome.
Article
Multidisciplinary Sciences
Lukas Anneser, Anja Gemmer, Tim Eilers, Ivan C. Alcantara, Anett-Yvonn Loos, Soojin Ryu, Erin M. Schuman
Summary: Behavior is influenced by both the environment and an animal's internal state, and different social contexts can modify anxiety levels and social behavior. The neuropeptide Pth2 in zebrafish plays a role in regulating behavior, particularly in anxiety and social preference.
Article
Psychiatry
J. Engelmann, L. Zillich, J. Frank, S. Wagner, M. Cetin, D. P. Herzog, M. B. Mueller, A. Tadic, J. C. Foo, L. Sirignano, D. F. Braus, N. Dahmen, S. Sordon, M. Riemenschneider, C. Spaniol, G. Gasparoni, M. Rietschel, S. H. Witt, K. Lieb, F. Streit
Summary: This study explores the relationship between DNA methylation and antidepressant response, and the results suggest its potential in personalized medicine for predicting patients' response before treatment.
TRANSLATIONAL PSYCHIATRY
(2022)
Letter
Biochemistry & Molecular Biology
G. Poggi, Malin Wennstrom, M. B. Mueller, G. Treccani
MOLECULAR PSYCHIATRY
(2023)
Article
Cell Biology
Constance Vennin, Charlotte Hewel, Hristo Todorov, Marlon Wendelmuth, Konstantin Radyushkin, Andre Heimbach, Illia Horenko, Sarah Ayash, Marianne B. Mueller, Susann Schweiger, Susanne Gerber, Beat Lutz
Summary: In a mouse model of chronic social defeat stress, the dorsal hippocampus plays a key role in neuroimmune responses, angiogenesis, myelination, and neurogenesis in a sub-group exhibiting molecular reactions upon chronic stress. Application of rapamycin after stress significantly increases stress resilience, providing new insights into molecular processes underlying stress responses and targeted interventions supporting resilience.
Article
Behavioral Sciences
David M. Lyons, Sarah Ayash, Alan F. Schatzberg, Marianne B. Muller
Summary: Laboratory mouse models play a crucial role in bridging the gap between basic neuroscience and applied stress research. This study examines the ecological validity of social defeat stressors in mouse models of emotional vulnerability and resilience. It was found that the majority of the reviewed reports (95%) focus on males, and many reports (71%) discuss vulnerability and resilience. Limited ecological validity leads to increased vulnerability and decreased resilience. Elements of limited ecological validity include repeated exposure to defeat stressors without opportunities to avoid or escape from pre-screened aggressive conspecifics, which is not representative of naturalistic conditions. Research is needed to establish causality and determine if ecologically valid stressors can build resilience in both sexes of mice.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Sarah Ayash, Thomas Lingner, Anna Ramisch, Soojin Ryu, Raffael Kalisch, Ulrich Schmitt, Marianne B. Mueller
Summary: This study establishes a translational mouse model that stratifies mice into three phenotypic subgroups based on their ability for threat-safety discrimination and conditioned learning. Transcriptome analysis reveals subgroup-specific differentially expressed genes and gene networks underlying the behavioral phenotypes. Overall, this research provides a valuable template for understanding the behavioral, molecular, and circuit bases of resilience in mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)