Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Maliheh Entezari, Courtney Clark, Amirhossein Zabolian, Ehsan Ranjbar, Mahdi Vasheghani Farahani, Hossein Saleki, Seyed Omid Sharifzadeh, Fatemeh Bakhtiari Far, Milad Ashrafizadeh, Saeed Samarghandian, Haroon Khan, Saeid Ghavami, Ali Zarrabi, Marek J. Los
Summary: Autophagy plays a dual role in normal cells and tumors, and targeting autophagy using nanoparticles can enhance cancer therapy. Nanocarriers can deliver autophagy regulators and chemotherapeutic agents, while nanomaterials can affect key components of autophagy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Pharmacology & Pharmacy
Yifang Zou, Fang Xiao, Liu Song, Bingxue Sun, Dandan Sun, Di Chu, Limei Wang, Shulan Han, Zhuo Yu, Caitriona M. O'Driscoll, Jianfeng Guo
Summary: The study demonstrated that the modified CD nanoparticles could enhance the combined efficacy of docetaxel and siRNA in the treatment of colorectal cancer, offering a promising therapeutic strategy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Zhi-Qiang Bai, Xiaofang Ma, Bin Liu, Tao Huang, Kaifeng Hu
Summary: This study provides a structural basis for understanding the interaction between c-FLIP and procaspase-8 and the molecular mechanisms of c-FLIP in regulating cell death.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Lital Cohen, Yoav D. Livney, Yehuda G. Assaraf
Summary: Prostate cancer treatment has significantly advanced in the past decade with the introduction of novel therapeutics and advanced imaging, but challenges such as temporary efficacy, therapy resistance, and metastasis still exist. New targeted therapeutic strategies are being developed to overcome these impediments and enhance antitumor activity while minimizing systemic toxicity.
DRUG RESISTANCE UPDATES
(2021)
Review
Immunology
Lina S. M. Huang, Evan Y. Snyder, Robert T. Schooley
Summary: AIDS caused by HIV-1 has been a global public health challenge for decades. While drugs targeting CCR5-mediated entry or HIV-1 replication have been used clinically, drugs targeting CXCR4 have not yet reached clinical application. Research is ongoing on discovering novel molecules targeting CXCR4 for potential future anti-HIV therapeutic development.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Environmental Sciences
Madhuri Grover, Tapan Behl, Monika Sachdeva, Simona Bungau, Lotfi Aleya, Dhruv Setia
Summary: Curcumin demonstrates significant anticancer potential through its multi-targeted effects, enhancing the effectiveness and reducing the side effects of combination therapy with other drugs. Aromatherapy has also shown promise in reducing cancer-related side effects, suggesting that it can be used as a supplementary therapy in cancer patients.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Hui Wang, Li Zhang, Zhaohua Miao, Meng Zhang, Hang Liu, Qiong He, Jialin Meng, Longping Wen, Zunfu Ke, Zhengbao Zha, Run Lin, Chaozhao Liang
Summary: Ferroptosis, a newly recognized form of cell death, can be utilized for cancer therapy by utilizing metal-free nanoplatforms like PSMA-targeted arsenic nanosheets (PMANs) that increase glutathione consumption, suppress specific gene expression, and promote the generation of reactive oxygen species and lipid peroxides. This approach shows promise for prostate cancer treatment, potentially enhancing the effectiveness of chemotherapy drugs like doxorubicin.
MATERIALS HORIZONS
(2021)
Article
Oncology
Paulo Roberto Del Valle, Samir Andrade Mendonca, Fernanda Antunes, Aline Hunger, Rodrigo E. Tamura, Daniela Bertolini Zanatta, Bryan E. Strauss
Summary: A modified non-replicating adenoviral vector was developed for gene transfer in colorectal cancer cells, showing enhanced sensitivity to chemotherapy and increased cell death rates. The approach may be effective for the treatment of colorectal cancer, allowing for the use of limited drug doses.
CANCER BIOLOGY & THERAPY
(2021)
Article
Oncology
Siji Zhu, Yujie Lu, Xiaochun Fei, Kunwei Shen, Xiaosong Chen
Summary: This study retrospectively analyzed the disease status and prognosis of HER2-low breast cancer patients who underwent neoadjuvant treatment. The results showed that compared to HER2-negative patients, HER2-low patients had a higher ER positivity rate, a similar pCR rate, and a better prognosis. Additionally, HER2-low status showed remarkable changes before and after treatment, suggesting the need for retesting HER2 status in the era of anti-HER2 ADCs therapy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I. Bush, Frank Caruso
Summary: Researchers successfully used NPC1-encoded mRNA to combat protein insufficiency and pathogenic phenotype caused by biallelic NPC1 mutations, achieving treatment for the rare disease NP-C1. The gene engineering strategies greatly improved the expression efficiency of the mRNA.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Guowei Gu, Lin Tian, Sarah K. Herzog, Yassine Rechoum, Luca Gelsomino, Meng Gao, Lili Du, Jin-Ah Kim, Derek Dustin, Hin Ching Lo, Amanda R. Beyer, David G. Edwards, Thomas Gonzalez, Anna Tsimelzon, Helen J. Huang, Natalie M. Fernandez, Sandra L. Grimm, Susan G. Hilsenbeck, Dan Liu, Jun Xu, Alyssa Alaniz, Shunqiang Li, Gordon B. Mills, Filip Janku, Ralf Kittler, Xiang H. -F. Zhang, Cristian Coarfa, Charles E. Foulds, W. Fraser Symmans, Sebastiano Ando, Suzanne A. W. Fuqua
Summary: Mutations in the estrogen receptor alpha gene (ESR1) are common in ER-positive metastatic breast cancer, leading to clinical resistance to aromatase inhibitors. Cells with the ESR1 Y537S mutation exhibit enhanced migration and invasion potential, and can become the predominant population in distant metastases. Androgen receptor (AR) levels are increased in mutant models, and AR agonists may play a role in inhibiting estrogen-regulated gene expression and distant metastasis in vivo.
Article
Materials Science, Multidisciplinary
Jing-Jing Hu, Qiming Yuan, Xiaoqi Dong, Yong Cheng, Lizhen Yuan, Jun Dai, Fan Xia, Xiaoding Lou
Summary: Researchers have designed a multi-fluorescence-labeled ternary complex for highly effective drug delivery and monitoring of multiple components in DDS. This complex can stably track the location of drugs and genes in the long term, and monitor the targeting-mediated endocytosis process over time, achieving superior inhibitory effects in tumor cells.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Polymer Science
Teoman Benli-Hoppe, Surhan Gol Ozturk, Ozgur Ozturk, Simone Berger, Ernst Wagner, Mina Yazdi
Summary: This study aimed to develop Tf receptor (TfR) targeted small interfering RNA (siRNA) polyplexes composed of synthetic, monodisperse, and sequence-defined subunits for efficient gene silencing in tumors. The use of an optimized cationizable lipo-oligoaminoamide (lipo-OAA) for siRNA core polyplex formation and retro-enantio peptide (reTfR) for targeting resulted in improved gene silencing in TfR-expressing cells. Additionally, plasmid DNA (pDNA) polyplexes were successfully used for receptor-mediated gene delivery in TfR-rich cells.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Tanveer A. Tabish, Mian Zahid Hussain, Roland A. Fischer, Angela Casini
Summary: Much progress has been made in subcellular targeted therapy of cancer by attacking disease cell's mitochondria. Mitochondrial dysfunction controls key metabolic changes and is related to tumor invasion, proliferation, tumorigenesis, and metastasis. Supramolecular metal-organic frameworks (MOFs) can be targeted to the tumor's mitochondria selectively and disrupt cancer cells' metabolic processes. Mitochondria-targeted MOFs (mitoMOFs) have the potential to revolutionize targeted therapy and improve therapeutic outcomes with minimal side-effects.
Review
Medicine, Research & Experimental
Preeti Ranjan, Vikash Kumar Dubey
Summary: Leishmaniasis is a parasitic disease that disproportionately affects impoverished and developing countries. The socioeconomic background of the affected region is a significant factor that influences the severity of the disease. The emergence of drug-resistant Leishmania poses a serious threat to current treatment options, necessitating a reevaluation of drug choices. Targeted therapy combined with immunotherapy appears to be a promising strategy for combating the disease.