期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 99, 期 -, 页码 85-96出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2015.11.005
关键词
Liposomes; Vaccines; Adjuvants; Antigens; Delivery systems; Microfluidics; QbD; MVA
资金
- EPSRC Centre for Innovative Manufacturing in Emergent Macromolecular Therapies [EP/IO33270/1]
- Aston University
- Novartis
- Nc3R grant [NC/L000261/1]
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/L000261/1] Funding Source: researchfish
Liposomes not only offer the ability to enhance drug delivery, but can effectively act as vaccine delivery systems and adjuvants. Their flexibility in size, charge, bilayer rigidity and composition allow for targeted antigen delivery via a range of administration routes. In the development of liposomal adjuvants, the type of immune response promoted has been linked to their physico-chemical characteristics, with the size and charge of the liposomal particles impacting on liposome biodistribution, exposure in the lymph nodes and recruitment of the innate immune system. The addition of immunostimulatory agents can further potentiate their immunogenic properties. Here, we outline the attributes that should be considered in the design and manufacture of liposomal adjuvants for the delivery of sub-unit and nucleic acid based vaccines. (C) 2015 Elsevier B.V. All rights reserved.
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