Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Peter Langer, Claas Ulrich, Juergen Eberle
Summary: This study investigated the efficacy of three indirubin derivatives in four cSCC cell lines, showing significant effects on cell proliferation, viability, and apoptosis. The mechanisms of action involved induction of reactive oxygen species and activation of various apoptotic pathways, highlighting the importance of ROS in antitumor effects of indirubins.
Review
Biochemistry & Molecular Biology
Gaetana Napolitano, Gianluca Fasciolo, Paola Venditti
Summary: Mitochondria in aerobic eukaryotic cells not only produce energy but also harmful substances such as ROS, and possess an efficient antioxidant system to detoxify these substances. As ROS production increases, mitochondria are damaged and release more harmful substances, but their antioxidant system can detoxify exogenous ROS at the expense of reducing the equivalents generated in mitochondria.
Review
Chemistry, Multidisciplinary
Yujie Dai, Yiming Ding, Linlin Li
Summary: Nanozymes possess high catalytic activity and stability, making them advantageous in generating or eliminating reactive oxygen species (ROS) for potential applications in disease therapy. Researchers are exploring catalytic mechanisms and strategies to design nanozyme-based platforms for cancer therapy, pathogen infection, neurodegenerative diseases, and more. Challenges and future opportunities for the development and application of nanozymes are also being discussed.
CHINESE CHEMICAL LETTERS
(2021)
Article
Fisheries
Lunjian Chen, Gen Kaneko, Yichao Li, Jun Xie, Guangjun Wang, Zhifei Li, Jingjing Tian, Kai Zhang, Wangbao Gong, Yun Xia, Ermeng Yu
Summary: The study found that natural oxidant faba beans can improve the muscle textural quality of grass carp, but dietary antioxidants supplementation almost completely abolishes this effect. However, the addition of oxidant (vitamin K3) to commercial feed can effectively improve the muscle textural quality of grass carp. There is a positive feedback relationship between ROS accumulation and production mainly in the mitochondria, which plays a role in improving muscle texture.
Review
Biochemistry & Molecular Biology
Silvia Piccirillo, Simona Magi, Alessandra Preziuso, Tiziano Serfilippi, Giorgia Cerqueni, Monia Orciani, Salvatore Amoroso, Vincenzo Lariccia
Summary: ROS have dual roles, acting as signaling molecules shaping physiological cell functions and as detrimental end products of unbalanced redox reactions. The brain is particularly vulnerable to ROS-mediated toxicity, which may influence the onset and progression of neurodegenerative diseases.
Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Article
Plant Sciences
A. Farjallah, H. Boubakri, F. Barhoumi, R. Brahmi, M. Gandour
Summary: The study identified Prx genes in the Brachypodium genus and examined their expression profiles under abiotic stress. The results showed that these genes are tissue specific and differentially expressed under salt or dehydration stress, accompanied by H2O2 accumulation. The study also revealed that Prx proteins may regulate key enzymes involved in lignin biosynthesis. These findings contribute to the understanding of the potential role of Prx genes in abiotic stress tolerance and provide a foundation for future research on genetically improving cereal lines.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Organic
Yalan Wu, Wenyi Huang, Danfeng Peng, Xin-An Huang, Jiangyong Gu, Shengjun Wu, Tao Deng, Fang Liu
Summary: A mild synthetic method has been presented for preparing dihydroquinolines which have shown great potential for fluorescence detection of biorelevant hydroxyl radicals (center dot OH). One of the synthetic dihydroquinolines has been demonstrated to enable sensitive and selective detection of center dot OH and intracellular organelle-targeted fluorescence imaging. Dihydroquinoline also exhibits promising potential for constructing advanced fluorescence probes for center dot OH with tunable photophysical properties.
Review
Biochemistry & Molecular Biology
Jason R. Treberg
Summary: Mitochondria play a central role in cellular reactive oxygen species, serving both as a potential source and due to their substantial antioxidant capacity. Studies focus on developing mitochondria as intrinsic regulators of H2O2 present challenges in integrating both consumption and production mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiaoluan Lu, Zhongshan He, Xiao Xiao, Xuelian Wei, Xiangrong Song, Shiyong Zhang
Summary: A new natural antioxidant-based nanodrug (VC@cLAVs) has been developed to treat atherosclerosis (AS) by loading antioxidants vitamin C (VC) into lipoic acid (LA)-constructed vesicles. This nanodrug not only increases the blood half-life of natural antioxidants but also enhances the antioxidation capacity through the mutual recycling of two redox pairs LA/DHLA and VC/DHA. In vivo results show that VC@cLAVs significantly reduces plaque area in mice compared to free VC and LA. This natural antioxidant-based nanodrug holds great potential for clinical applications.
Review
Chemistry, Multidisciplinary
Gabriel T. Huynh, Vidhishri Kesarwani, Julia A. Walker, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: The combination of nanomaterials and fluorescent detection offers new opportunities for monitoring oxygen and ROS in biological systems, improving optical properties and interactions with cells and media, and providing ratiometric sensing robust to environmental drift.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.