Article
Oncology
Yue Liu, Joanna Pagacz, Donald J. Wolfgeher, Kenneth D. Bromerg, Jacob Gorman, Stephen J. Kron
Summary: Antigen presentation may be the limiting factor in the low immune response to radiation therapy, and combining immune checkpoint blockade does not restore cytotoxic T lymphocytes function. Therapeutic vaccines based on senescent tumor cells or SnC-activated dendritic cells have the potential to enhance immune therapies and limit recurrence or metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Mehrshad Ebrahim Pour, Samin Ghorbani Moghadam, Parian Shirkhani, Amirhossein Sahebkar, Fatemeh Mosaffa
Summary: Cell-based vaccines show promise as a potential therapeutic approach for GBM, with favorable safety profiles and modest improvements in patient survival. However, further advancements are needed to overcome limitations, such as the development of potent antigens and optimization of dosage regimens.
Article
Oncology
Xiaowu Bai, Chi Chun Wong, Yasi Pan, Huarong Chen, Weixin Liu, Jianning Zhai, Wei Kang, Yu Shi, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Philip Chiu, Jun Yu, Enders Kwok-wai Ng
Summary: YTHDF1 is overexpressed in gastric cancer and promotes cancer growth by inducing cell proliferation and suppressing dendritic cell-mediated anti-tumor immune response. YTHDF1 is a promising therapeutic target for gastric cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Katerina Kalkusova, Sindija Smite, Elea Darras, Pavla Taborska, Dmitry Stakheev, Luca Vannucci, Jirina Bartunkova, Daniel Smrz
Summary: The immune checkpoint inhibitors are crucial in cancer immunotherapy, but their efficacy is limited in solid tumors. Mast cells and dendritic cells play important roles in the tumor immune microenvironment and controlling these cells may help overcome the resistance of solid tumors to immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Angeliki Datsi, Ruediger V. Sorg
Summary: Dendritic cell vaccination (DCV) is a promising immunotherapy for treating glioblastomas, with numerous trials showing potential but some controlled studies failing to detect a survival benefit. Further exploration is needed to fully understand the potential of this therapeutic approach.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Erin F. Simonds, Edbert D. Lu, Oscar Badillo, Shokoufeh Karimi, Eric Liu, Whitney Tamaki, Chiara Rancan, Kira M. Downey, Jacob Stultz, Meenal Sinha, Lauren K. McHenry, Nicole M. Nasholm, Pavlina Chuntova, Anders Sundstrom, Vassilis Genoud, Shilpa A. Shahani, Leo D. Wang, Christine E. Brown, Paul R. Walker, Fredrik J. Swartling, Lawrence Fong, Hideho Okada, William A. Weiss, Mats Hellstrom
Summary: This study compared the tumor immune microenvironments of ICI-responsive and ICI-refractory tumors, identifying T cells and dendritic cells as key factors associated with ICI sensitivity. Mouse models suggested that poor antigen presentation in the brain may contribute to ICI resistance in GBM. Rational immunotherapeutic combinations targeting DCs and PD-L1+ tumor-associated macrophages showed promising results in vivo.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Xi Zhang, Tianhui He, Yuan Li, Ling Chen, Hongyu Liu, Yu Wu, Hongyan Guo
Summary: Ovarian cancer is characterized by uncertain presentation and poor outcomes, with surgery and chemotherapy being the current basis of treatment. However, there are limitations due to advanced stage at diagnosis and high recurrence rate. The use of anti-VEGF agents, PARP inhibitors, and immunotherapies are being explored to enhance treatment outcomes, but the population that can benefit from these treatments remains limited.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shafiq Murad, Susanne Michen, Alexander Becker, Monika Fussel, Gabriele Schackert, Torsten Tonn, Frank Momburg, Achim Temme
Summary: NKG2C+ NK cells show increased cytotoxicity against gliomas, indicating potential therapeutic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Georges Herbein
Summary: Human cytomegalovirus (HCMV) is a common herpesvirus that can cause both lytic and latent infection. It can lead to severe symptoms and even promote the development of cancer cells. Understanding the immune landscape and tumor microenvironment in HCMV-associated tumors is crucial for developing effective therapeutic approaches.
Article
Multidisciplinary Sciences
Nicolas Cuburu, Lukasz Bialkowski, Sergio M. Pontejo, Shiv K. Sethi, Alexander T. F. Bell, Rina Kim, Cynthia D. Thompson, Douglas R. Lowy, John T. Schiller
Summary: Tumor infiltration by T cells plays a significant role in cancer progression and immunotherapy. This study explores the use of intratumoral injection of virus-derived peptide epitopes to activate preexisting antiviral T cell responses and promote antitumor responses or antigen spreading. The results show that this approach can act as a standalone therapy to control tumor growth and induce long-term antitumor immunity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Ting Su, Shurong Zhou, Suling Yang, Nicholas Humble, Fuwu Zhang, Guocan Yu, Paula D. Bos, Furong Cheng, Kristoffer Valerie, Guizhi Zhu
Summary: This study reports a radioimmunotherapy for adult brain cancer that combines radiotherapy, immune checkpoint blockade, and lymph-node-targeting vaccines. The vaccines induced anti-cancer immune responses in mice and enhanced therapeutic efficacy in orthotopic brain cancer mice. However, radioimmunotherapy only showed a trend towards improved efficacy compared to radiotherapy alone.
Article
Biochemistry & Molecular Biology
Mariangela O. Silva, Bianca S. Almeida, Natiely S. Sales, Mariana O. Diniz, Luana R. M. M. Aps, Karine B. Rodrigues, Jamile R. Silva, Ana C. R. Moreno, Bruna F. M. M. Porchia, Fernando B. Sulczewski, Silvia B. Boscardin, Luis C. S. Ferreira
Summary: The delivery of HPV tumor antigens to DCs, particularly via the DEC205 surface receptor, is a promising therapeutic approach, providing new opportunities for the development of alternative immunotherapies for patients with HPV-associated tumors.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Alessandra De Leo, Alessio Ugolini, Filippo Veglia
Summary: Glioblastoma (GBM) is a highly aggressive and malignant brain tumor with a unique immune microenvironment that is resistant to immunotherapy. Myeloid cells play a crucial role in regulating immune and therapeutic responses in GBM. Studying the characteristics and functions of different populations of myeloid cells in GBM offers new insights for targeting specific cells for therapeutic purposes.
Review
Cell Biology
Kyu-Won Lee, Judy Wai Ping Yam, Xiaowen Mao
Summary: In the era of cancer immunotherapy, immune checkpoint blockades (ICBs) and adoptive cell transfer therapies (ACTs) have limitations. Dendritic cell (DC)-based vaccines are suggested as a new cancer immunotherapy regimen that can address these limitations. Different types of innovative DC vaccines are under investigation, which are expected to provide breakthroughs in cancer immunotherapy.
Review
Biotechnology & Applied Microbiology
Morgan E. Janes, Alexander P. Gottlieb, Kyung Soo Park, Zongmin Zhao, Samir Mitragotri
Summary: Vaccines are important tools in immunotherapy for cancer treatment. This article provides an update on the clinical status of cancer vaccines, including analyses of 360 ongoing trials and the introduction of eight globally approved products. The article also discusses current limitations and future applications for clinical translation of cancer vaccines.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Tatiana Jofra, Roberta Di Fonte, Tarun Edgar Hutchinson, Farhad Dastmalchi, Giuseppe Galvani, Manuela Battaglia, Shahram Salek-Ardakani, Georgia Fousteri
IMMUNOLOGY AND CELL BIOLOGY
(2017)
Article
Immunology
Georges Abboud, Pritesh Desai, Farhad Dastmalchi, Jessica Stanfield, Vikas Tahiliani, Tarun E. Hutchinson, Shahram Salek-Ardakani
JOURNAL OF EXPERIMENTAL MEDICINE
(2016)
Article
Immunology
Pritesh Desai, Vikas Tahiliani, Tarun E. Hutchinson, Farhad Dastmalchi, Jessica Stanfield, Georges Abboud, Paul G. Thomas, Carl F. Ware, Jianxun Song, Michael Croft, Shahram Salek-Ardakani
JOURNAL OF IMMUNOLOGY
(2018)
Article
Oncology
Aida Karachi, Farhad Dastmalchi, Duane A. Mitchell, Maryam Rahman
Article
Oncology
Aida Karachi, Changlin Yang, Farhad Dastmalchi, Elias J. Sayour, Jianping Huang, Hassan Azari, Yu Long, Catherine Flores, Duane A. Mitchell, Maryam Rahman
Article
Oncology
Farhad Dastmalchi, Aida Karachi, Changlin Yang, Hassan Azari, Elias Joseph Sayour, Anjelika Dechkovskaia, Alexander Loren Vlasak, Megan Ellen Saia, Rolando Eladio Lovaton, Duane Anthony Mitchell, Maryam Rahman
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Meeting Abstract
Clinical Neurology
Maryam Rahman, Aida Karachi, Changlin Yang, Farhad Dastmalchi, Elias Sayour, Jianping Huang, Duane Mitchell
JOURNAL OF NEUROSURGERY
(2019)
Meeting Abstract
Clinical Neurology
Maryam Rahman, Maryam Rahman, Farhad Dastmalchi, Elias Sayour, Changlin Yang, Anjelika Vashkevich, Alex Vlasak, Megan Saia, Duane Mitchell
JOURNAL OF NEUROSURGERY
(2019)
Meeting Abstract
Oncology
Farhad Dastmalchi, Aida Karachi, Alexander Vlasak, Hassan Azari, Usma Baban, Duane Mitchell, Maryam Rahman
Meeting Abstract
Oncology
Aida Karachi, Farhad Dastmalchi, Changlin Yang, Jianping Huang, Elias Sayour, Duane Mitchell, Maryam Rahman
Meeting Abstract
Oncology
Aida Karachi, Farhad Dastmalchi, Changlin Yang, Jianping Huang, Duane Mitchell, Maryam Rahman
Meeting Abstract
Oncology
Farhad Dastmalchi, Aida Karachi, Jonathan R. Allison, Kari B. Basso, Duane Mitchell, Maryam Rahman
Meeting Abstract
Oncology
Farhad Dastmalchi, Aida Karachi, Hassan Azari, Duane Mitchell, Maryam Rahman
Meeting Abstract
Oncology
Farhad Dastmalchi, Aida Karachi, Ram Khattri, Matthew E. Merritt, Duane Mitchell, Maryam Rahman
