Article
Cardiac & Cardiovascular Systems
Bjorn Hornestam, Martin Adiels, Kok Wai Giang, Per-Olof Hansson, Lena Bjorck, Annika Rosengren
Summary: The study found that there is a significantly higher risk of VTE in the first 30 days after diagnosis for patients with AF, especially in women. The risk decreases with the introduction of oral anticoagulation therapy, but remains slightly elevated in women even after 9 months.
Article
Oncology
Berit Sunde, Mats Lindblad, Marlene Malmstrom, Jakob Hedberg, Pernilla Lagergren, Magnus Nilsson
Summary: A Swedish study found that patients with esophageal cancer reported low function scores and severe symptoms 1 year after diagnosis, regardless of receiving curative or palliative management. Patients who underwent surgery had more issues with diarrhea, while those treated with chemoradiotherapy had more frequent dysphagia.
Review
Oncology
Maria Davern, Noel E. Donlon, Robert Power, Conall Hayes, Ross King, Margaret R. Dunne, John V. Reynolds
Summary: Oesophageal cancer is associated with gastro-oesophageal reflux disease, obesity, and tobacco use. Knowledge of the tumour microenvironment is crucial for understanding OC development and therapy sensitivity. Immunological characterisation can provide prognostic implications and enable precision medicine for OC patients.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Catherine Zhou, Marieke Louwman, Marlies Wakkee, Astrid Van der Veldt, Dirk Grunhagen, Cornelis Verhoef, Antien Mooyaart, Tamar Nijsten, Loes Hollestein
Summary: Melanoma of the skin is the most lethal form of skin cancer, with a substantial proportion of patients initially diagnosed with early-stage disease progressing to metastatic disease, highlighting the need for further research on high-risk patients.
Article
Oncology
Sirus Rabbani, Fredrik Mattsson, Jesper Lagergren, Shaohua Xie
Summary: This nationwide Swedish study found no evidence to support the hypothesis that the use of 5-ARIs improves survival in patients with oesophago-gastric cancer.
Article
Oncology
Disa Dahlman, Xinjun Li, Hedvig Magnusson, Jan Sundquist, Kristina Sundquist
Summary: Women with drug use disorders (DUD) in Sweden have a lower likelihood of participating in cervical cancer screening programs, making them a high-risk group for incident cervical cancer. More research is needed on the impact of non-attendance in cancer screening and other healthcare seeking barriers on the risk of incident cervical cancer among women with DUD.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Rohit R. Badia, Daniel Wong, Rashed Ghandour, Nathan Chertack, Xiaosong Meng, Ryan Hutchinson, Vitaly Margulis, Yair Lotan, Alejandra Madrigales, Solomon Woldu, Aditya Bagrodia
Summary: This study evaluated the accuracy of institutional registry for testicular germ cell tumors and found substantial inconsistencies in N stage, S stage, and composite stage. An educational intervention to improve data abstraction led to increased concordance. This highlights the need for improved clarification of staging guidelines, dynamic institutional internal auditing, and training reform within cancer registries.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Mike van Dooren, Elise A. J. de Savornin Lohman, Eva Brekelmans, Pauline A. J. Vissers, Joris I. Erdmann, Andries E. Braat, Jeroen Hagendoorn, Freek Daams, Ronald M. van Dam, Marieke T. de Boer, Peter B. van den Boezem, Bas Groot Koerkamp, Philip R. de Reuver
Summary: For patients with gallbladder cancer, disseminated disease is often found during (re-)exploration. This study aimed to assess the effectiveness of staging laparoscopy and identify predictive factors for disseminated disease. The results showed that staging laparoscopy can identify disseminated disease in some cases, and cholecystitis and primary R1/R2 resection are independent factors predicting disseminated disease.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Wen-Ru Chou, Ben-Chang Shia, Yen-Chun Huang, Chieh-Wen Ho, Mingchih Chen
Summary: This study investigated multiple primary malignancies involving lung cancer based on the Taiwan Cancer Database. It found differences in characteristics between patients with lung cancer first and other cancer first, with longer survival time in the lung cancer first group. Patients with EGFR mutations showed varying survival outcomes in different stages.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Urgena Maharjan, Joonas H. Kauppila
Summary: This study assessed the registry coverage for gastric cancer in FCR and HILMO in Finland. The results showed that gastric cancer was well captured by both registries, but there was a decrease in the proportion of cases reported to FCR over time. The completeness of FCR was estimated at 87% and for HILMO, it was 92.7%. Death due to gastric cancer was most common in those with gastric cancer reported in both registries.
Article
Oncology
Malin Lonnerblad, Eva Berglund, Maria Aberg, Klas Blomgren
Summary: This study reveals the occupational challenges faced by survivors of pediatric brain tumors. Compared to controls, they are more likely to receive sickness or activity compensation, have lower employment rates, and have higher rates of parental leave. These issues are not only limited to patients with high-grade tumors, but also affect those with low-grade tumors.
Article
Medical Informatics
Yuri Tolkach, Lisa Marie Wolgast, Alexander Damanakis, Alexey Pryalukhin, Simon Schallenberg, Wolfgang Hulla, Marie-Lisa Eich, Wolfgang Schroeder, Anirban Mukhopadhyay, Moritz Fuchs, Sebastian Klein, Christiane Bruns, Reinhard Buettner, Florian Gebauer, Birgid Schoemig-Markiefka, Alexander Quaas
Summary: An artificial intelligence (AI) algorithm was developed for tumor tissue detection and regression grading in surgical specimens from patients with oesophageal adenocarcinoma or adenocarcinoma of the oesophagogastric junction. The AI tool showed high accuracy and concordance with pathologists' assessments, and significantly reduced diagnostic time.
LANCET DIGITAL HEALTH
(2023)
Article
Multidisciplinary Sciences
Yuan-Chun Huang, Pei-Tseng Kung, Shang-Yun Ho, Yeu-Sheng Tyan, Li-Ting Chiu, Wen-Chen Tsai
Summary: MDT care has shown significant benefits for the survival of esophageal cancer patients, especially in late-stage cancer patients where a greater reduction in risk has been observed.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Malin Lonnerblad, Maria Aberg, Klas Blomgren, Eva Berglund
Summary: Individuals treated for childhood brain tumors have lower attendance rates in high school and university compared to controls. This is particularly true for those treated for embryonal tumors or optic pathway gliomas. Parental education levels are positively correlated with attendance rates.
Article
Oncology
Albin Grundstrom, Arja Harila, Malin Lonnerblad
Summary: Pediatric sarcoma survivors have poorer academic performance compared to peers without cancer in multiple school subjects. Survivors seem to catch up during post-compulsory education, but might struggle to find employment.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Surgery
K. Van Den Heede, T. Claerhout, S. Jansen, S. Blontrock, N. Brusselaers, S. Van Slycke
Summary: This long-term follow-up study by a single surgeon in a single center confirms the safety and excellent cure rates of surgery for renal hyperparathyroidism (rHPT), while highlighting the importance of long-term follow-up.
ACTA CHIRURGICA BELGICA
(2023)
Article
Gastroenterology & Hepatology
Sharon Ngwenya, Johanna Simin, Nele Brusselaers
Summary: This study investigated the association between long-term use of proton pump inhibitors (PPIs) and all-cause mortality and cause-specific mortality. The results showed that PPI use was associated with increased risks of both all-cause mortality and cause-specific mortality, and the risks increased with prolonged duration of use.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Nutrition & Dietetics
Lea Ribet, Robin Dessalles, Corinne Lesens, Nele Brusselaers, Mickael Durand-Dubief
Summary: Food fermentation using sourdough, consisting of lactic bacteria and yeasts, is considered natural and beneficial. This study reviewed clinical evidence on the effects of sourdough bread on health and found that there is currently no clear consensus on its benefits compared to other bread types. Factors such as microbial composition, fermentation parameters, and cereal and flour types may influence the nutritional properties of bread. However, specific strains and fermentation conditions showed improvements in glycemic response, satiety, and gastrointestinal comfort. Further standardization is needed to determine the clinical health benefits of sourdough.
ADVANCES IN NUTRITION
(2023)
Article
Biology
Linnea Hases, Lina Stepanauskaite, Madeleine Birgersson, Nele Brusselaers, Ina Schuppe-Koistinen, Amena Archer, Lars Engstrand, Cecilia Williams
Summary: A high-fat diet can cause gut microbiota dysbiosis, chronic intestinal inflammation, and metabolic syndrome. There are sex differences in the microbiota composition, and female mice are less affected. Estrogenic ligands can attenuate high-fat diet-induced dysbiosis and impact the microbial composition, especially in males.
COMMUNICATIONS BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Lembris L. Njotto, Johanna Simin, Romina Fornes, Ingvild Odsbu, Isabelle Mussche, Steven Callens, Lars Engstrand, Robin Bruyndonckx, Nele Brusselaers
Summary: This study found that maternal and early-life antibiotic use is associated with an increased risk of autism and ADHD in children. The study used a large Swedish nation-wide cohort and discovered that both prenatal and early childhood antibiotic exposure are linked to a higher risk of developing these neurodevelopmental disorders. Rating: 8 out of 10.
Article
Obstetrics & Gynecology
Unnur Gudnadottir, Juan Du, Luisa W. W. Hugerth, Lars Engstrand, Ina Schuppe-Koistinen, Eva Wiberg Itzel, Emma Fransson, Nele Brusselaers
Summary: This study aims to identify factors associated with pre-pregnancy complications and poor well-being in early pregnancy. Findings from an online questionnaire survey in Sweden showed a high incidence of pre-pregnancy complications, with risk factors including diagnosed endometriosis, thyroid medication, opioids and other strong pain medication, body mass index > 25 kg/m², and age over 35 years. Different subgroups of pre-pregnancy complications had unique risk factors, and women with recurrent pregnancy loss had a higher risk of depression in their current pregnancy.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Infectious Diseases
Frank Mulindwa, Barbara Castelnuovo, Nele Brusselaers, Robert Bollinger, Joshua Rhein, Mutebi Edrisa, Allan Buzibye, Willington Amutuhaire, George Yendewa, Sarah Nabaggala, Eva Laker Agnes Odongpiny, Ronald Kiguba, Aisha Nakawooza, Simon Dujanga, Martin Nabwana, Jean-Marc Schwarz
Summary: According to the study, the incidence of type 2 diabetes is low in Ugandan HIV patients using dolutegravir (DTG), and the changes in blood glucose in the first 48 weeks of treatment are independent of conventional risk factors. Therefore, restricting the use of dolutegravir in Ugandan ART naive patients may be unwarranted.
AIDS RESEARCH AND THERAPY
(2023)
Article
Immunology
Willington Amutuhaire, Frank Mulindwa, Barbara Castelnuovo, Nele Brusselaers, Jean-Marc Schwarz, Mutebi Edrisa, Simon Dujanga, Robert A. Salata, George A. Yendewa
Summary: This study aimed to assess the prevalence and risk factors of metabolic syndrome (MetS) and its components in adult Ugandan people with HIV initiating antiretroviral therapy. The findings showed that cardiometabolic risk factors were common in this population, highlighting the need for surveillance and management of comorbidities in Uganda and similar settings.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Review
Endocrinology & Metabolism
Frank Mulindwa, Habiba Kamal, Barbara Castelnuovo, Dathan M. Byonanebye, Jean-Marc Schwarz, Robert Bollinger, Nele Brusselaers
Summary: This meta-analysis found that there is no significant association between integrase strand transfer inhibitors (INSTIs) and an increased risk of type 2 diabetes mellitus (DM) compared to other antiretroviral therapies (ARTs), except in the African population. However, it is important to note that exposure to INSTIs may increase the risk of DM in African populations. Additionally, lower risk of DM was observed in studies involving ART-naive patients and longer follow-up periods.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Microbiology
Justine W. Debelius, Lars Engstrand, Andreas Matussek, Nele Brusselaers, James T. Morton, Margaretha Stenmarker, Renate S. Olsen
Summary: The gut microbiome has a relationship with survival in colorectal cancer, with single organisms serving as markers of poor prognosis. However, in situ imaging of tumors reveals a polymicrobial tumor-associated community. In this study, a nested case-control approach was used to investigate the role of these polymicrobial communities in survival. The findings suggest that a polymicrobial tumor-specific microbiome is associated with survival in late-stage colorectal cancer patients.
MICROBIOLOGY SPECTRUM
(2023)
Article
Cell Biology
Sanjiv Risal, Congru Li, Qing Luo, Romina Fornes, Haojiang Lu, Gustaw Eriksson, Maria Manti, Claes Ohlsson, Eva Lindgren, Nicolas Crisosto, Manuel Maliqueo, Barbara Echiburu, Sergio Recabarren, Teresa Sir Petermann, Anna Benrick, Nele Brusselaers, Jie Qiao, Qiaolin Deng, Elisabet Stener-Victorin
Summary: The transgenerational effects of PCOS in female progeny are being investigated. This study examines whether sons born to mothers with PCOS transmit reproductive and metabolic phenotypes to their male progeny. The results show that PCOS-sons are more likely to be obese and have dyslipidemia, and a mouse model confirms that these dysfunctions are passed down to multiple generations. The study highlights the potential risk of transmission of reproductive and metabolic dysfunction through the male germline.
CELL REPORTS MEDICINE
(2023)
Article
Medicine, Research & Experimental
Wen Zhong, Hanna Danielsson, Nele Brusselaers, Dirk Wackernagel, Ulrika Sjobom, Karin Savman, Ingrid Hansen Pupp, David Ley, Anders K. Nilsson, Linn Fagerberg, Mathias Uhlen, Ann Hellstrom
Summary: This study investigated the changes in blood protein profiles during the first months of life in preterm infants and found that the variations in blood protein expression are mainly associated with the postnatal age of the infants. This provides an increased understanding of the development process after extremely preterm birth.
COMMUNICATIONS MEDICINE
(2023)
Letter
Public, Environmental & Occupational Health
Frank Mulindwa, Jean-Marc Schwarz, Nele Brusselaers, Simon Dujanga, George Yendewa, Barbara Castelnuovo
PAN AFRICAN MEDICAL JOURNAL
(2023)
Article
Surgery
Fien Van den Eynde, Klaas Van den Heede, Nele Brusselaers, Sam Van Slycke
Summary: The need for thyroid surgery is increasing in the elderly population due to aging, increased use of imaging studies, and higher prevalence of thyroid nodules and cancer. This study compared surgical outcomes in different age groups and found that patients aged 75 and older had a higher risk of complications, particularly bleeding, indicating that ambulatory surgery is not advisable for this age group.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Klaas Van Den Heede, Nele Brusselaers, Esmee Breddels, Sebastien Gaujoux, Camille Buffet, Fabrice Menegaux, Nathalie Chereau
Summary: This study evaluated the prognostic impact of lymph node characteristics on patients with therapeutic neck dissection for clinically N1 classic PTC. The results showed that the number of harvested lymph node, presence of lymph node capsular rupture, and total lymph node ratio were associated with disease persistence or recurrence.
