Review
Nutrition & Dietetics
Carmen Purdel, Denisa Margina, Ines Adam-Dima, Anca Ungurianu
Summary: This article discusses the effects of different dietary interventions on the gut microbiota and their importance for human health.
Review
Food Science & Technology
Luanfeng Wang, Fang Wang, Ling Xiong, Haizhao Song, Bo Ren, Xinchun Shen
Summary: In recent years, dietary restriction (DR) has gained popularity for its potential to improve metabolism and promote longevity. However, the role of gut microbiota in DR has been less explored. This review discusses the effects of different DR patterns on the gut microbiota and the underlying mechanisms by which DR affects metabolic health. It also suggests the development of personalized microbiome-directed DR and advanced sequencing technologies for accurate analysis. DR effectively modulates the gut microbiota and improves metabolic syndrome, inflammatory bowel disease, and cognitive impairment. Further research is needed to fully understand the mechanisms behind the benefits of DR.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Microbiology
Julia Sbierski-Kind, Sophia Grenkowitz, Stephan Schlickeiser, Arvid Sandforth, Marie Friedrich, Desiree Kunkel, Rainer Glauben, Sebastian Brachs, Knut Mai, Andrea Thuermer, Aleksandar Radonic, Oliver Drechsel, Peter J. Turnbaugh, Jordan E. Bisanz, Hans-Dieter Volk, Joachim Spranger, Reiner Jumpertz von Schwartzenberg
Summary: Caloric restriction can improve metabolic health, reduce body fat accumulation, and enhance glucose tolerance, while delaying immune senescence by reducing specific cellular immune responses. This suggests that modulation of the gut microbiome could lead to the development of new therapeutic options for metabolic diseases.
Review
Nutrition & Dietetics
Malgorzata Anna Marc, Rafal Jastrzab, Jennifer Mytych
Summary: This article summarizes the latest knowledge on the correlation between gut microbiota dysbiosis and neurodegenerative and brain-related diseases such as Alzheimer's and Parkinson's. It emphasizes the importance of gut-derived metabolites and gut metabolic status as key factors in gut-brain crosstalk and their impact on the severity of neural conditions.
Article
Microbiology
Mohammed K. Hankir, Petia Kovatcheva-Datchary, Rebecca Springer, Annett Hoffmann, Joerg Vogel, Florian Seyfried, Tulika Arora
Summary: This study found that RYGB surgery alters the composition of the gut microbiota in obese rats and identified a specific unidentified Erysipelotrichaceae species that is linked to improved glycemic control in RYGB-treated rats. Fecal microbiota transplantation experiments demonstrated that the improved glycemic control in RYGB-treated rats can be transferred to germfree mice. Furthermore, supplementing RYGB recipient mice with L. muris, a member of the Erysipelotrichaceae family, further improved glycemic control. These findings suggest that the gut microbiota contributes to weight loss-independent improvements in glycemic control after RYGB.
MICROBIOLOGY SPECTRUM
(2023)
Article
Food Science & Technology
Andras Gregor, Sandra Auernigg-Haselmaier, Manuel Malleier, Stefan Bruckberger, Joana Seneca, Petra Pjevac, Marc Pignitter, Kalina Duszka
Summary: Previously, we found that caloric restriction (CR) led to increased levels of taurine and taurine-conjugated bile acids (BA) in the gut. In this study, we discovered that restrictive diets, such as intermittent fasting and fasting-mimicking diet, had a similar effect as CR. The type of cage bedding affected the levels of BAs and taurine, and removal of cage bedding reversed the CR phenotype. Microbiota transplant from CR mice increased BAs deconjugation. Inhibition of bile salt hydrolase (BSH) prevented the increase in free taurine while increasing taurine-conjugated BA levels. Consuming high fiber diets increased taurine conjugates without elevating BAs levels.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Immunology
Yajuan Fan, Yuan Gao, Qingyan Ma, Zai Yang, Binbin Zhao, Xiaoyan He, Jian Yang, Bin Yan, Fengjie Gao, Li Qian, Wei Wang, Feng Zhu, Xiancang Ma
Summary: Schizophrenia is associated with immune dysfunctions and disturbed intestinal microbiota. This study found that abnormal gut metabolism-immune network exists in schizophrenia, and gut microbiota may influence immune responses by regulating host metabolic processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ting Chen, Yufeng Qin, Minjian Chen, Yuqing Zhang, Xu Wang, Tianyu Dong, Guanglin Chen, Xian Sun, Ting Lu, Richard Allen White, Peng Ye, Hein M. Tun, Yankai Xia
Summary: This study revealed significant changes in the meconium microbiota of neonates born to mothers with gestational diabetes mellitus (GDM), with a reduction in alpha diversity and alterations in the abundance of Firmicutes and Proteobacteria. Metabolomic analysis showed changes in metabolic pathways such as taurine and hypotaurine metabolism, pyrimidine metabolism, beta-alanine metabolism, and bile acid biosynthesis in GDM subjects. The findings highlight the impact of maternal factors on early-life metabolism.
Article
Clinical Neurology
Yu Kong, Zhongyun Chen, Xuedan Feng, Ya Zuo, Jing Zhang
Summary: This study evaluated the changes in gut microbiota and metabolites in patients with sporadic Creutzfeldt-Jakob disease (sCJD) and found significant differences compared to healthy controls. Certain bacteria taxa were increased in sCJD patients, while metabolites related to phenylpropanoid biosynthesis showed a prominent decrease. Additionally, metabolites involved in linoleic acid metabolism and steroid hormone biosynthesis were associated with disease severity. These findings provide new insights into the relationship between gut microbiota, metabolites, and sCJD, and suggest potential biomarkers for disease evaluation.
JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Alex E. Mohr, Paniz Jasbi, Devin A. Bowes, Blake Dirks, Corrie M. Whisner, Karen M. Arciero, Michelle Poe, Haiwei Gu, Eric Gumpricht, Karen L. Sweazea, Paul J. Arciero
Summary: Nutritional interventions, such as intermittent fasting, show potential benefits in addressing obesity and cardiometabolic dysfunction by modulating body weight regulation, gut microbiome, and plasma metabolome. This study analyzed the impact of a four-week intermittent fasting intervention on overweight and obese adults and found that it modestly influenced gut microbiome community structure and plasma metabolome, suggesting its viability as a nutritional intervention strategy.
FRONTIERS IN NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Andras Gregor, Marc Pignitter, Slave Trajanoski, Sandra Auernigg-Haselmaier, Veronika Somoza, Juergen Koenig, Kalina Duszka
Summary: The study revealed that microbiota plays a critical role in the intestinal response to caloric restriction-induced changes in taurine, bile acids, and GST levels. Antibiotics treatment that depleted gut bacteria diminished the specific increase in these levels, highlighting the importance of microbiota in modulating metabolic responses to caloric restriction. Transplant of microbiota from caloric restriction mice induced similar changes in gene expression and metabolite levels in ad libitum fed mice, further emphasizing the influence of microbiota on metabolic pathways.
Article
Agriculture, Multidisciplinary
Chu Wan, Kaizhang Wu, Xingyu Lu, Fang Fang, Yaqian Li, Yumin Zhao, Shubo Li, Jie Gao
Summary: The study found that different culture media have varying effects on the bacterial community structure and metabolites, with the AMB medium being the most effective in maintaining a stable bacterial community structure and producing fewer metabolites and short-chain fatty acids. Culturing with AMB medium for 48 hours is considered the most suitable in vitro model for human gut microbiota fermentation, providing an alternative approach for diet and health research.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Li, Jiali Dong, Huiwen Xiao, Bin Wang, Zhiyuan Chen, Shuqin Zhang, Yuxiao Jin, Yiliang Li, Saijun Fan, Ming Cui
Summary: The study investigates the impact of a 30% caloric restriction diet on radiation damage. Results show that short-term CR pretreatment can restore hematogenic organs, improve intestinal architecture, and alleviate enteric and systemic inflammation. Furthermore, CR diet alters gut microbiota composition to provide radiation protection in a sex-specific manner for male and female mice.
Article
Biochemistry & Molecular Biology
Karin Kleigrewe, Martina Haack, Martine Baudin, Thomas Menabreaz, Julien Crovadore, Mahmoud Masri, Michael Beyrer, Wilfried Andlauer, Francois Lefort, Corinna Dawid, Thomas B. Brueck, Wolfram M. Brueck
Summary: Flaxseeds are a nutritious food that can influence the gut microbiota and exhibit hypolipidemic and anti-inflammatory activities. Both whole flaxseeds and flaxseed press cake have similar effects on the microbiota and functionality, but the press cake may be more acceptable as a functional additive in foods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Feng Zhao, Rui An, Liqian Wang, Jikang Shan, Xianjun Wang
Summary: The study identified a complex relationship between gut microbiota and various metabolites, such as glycerophospholipids and imidazopyrimidines, which may serve as potential diagnostic biomarkers and therapeutic targets for lung cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Xi Li, Yinan Zhang, Lingya Xu, Aoxue Wang, Yejun Zou, Ting Li, Li Huang, Weicai Chen, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang, Joseph Loscalzo, Yi Yang, Yuzheng Zhao
Summary: In this study, a highly sensitive lactate sensor called FiLa was developed, which allows for monitoring subtle lactate fluctuations in living cells and animals. It was found that lactate is highly enriched in mammalian mitochondria and functions as a key hub sensing various metabolic activities. The FiLa sensors also enable direct imaging of elevated lactate levels in diabetic mice and provide a simple, rapid, and sensitive lactate assay for clinical screening. Overall, the FiLa sensors are powerful and broadly applicable tools for studying lactate metabolism in health and disease.
Article
Biochemical Research Methods
Kun Ge, Dan Zheng, Jieyi Wang, Wei Jia, Aihua Zhao
Summary: A simple and rapid method for the quantification of ceramides in liver and small intestine tissues was developed and applied. The method demonstrated good sensitivity and linearity, as well as stable extraction recoveries and precision. The composition of ceramides in the two tissues provides insights for exploring biomarkers and molecular mechanisms of ceramide-related diseases.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Oncology
Zongmei Zheng, Xinxin Hou, Zhaoxiang Bian, Wei Jia, Ling Zhao
Summary: This review explores the crucial role of gut microbiota in the metastasis of colorectal cancer (CRC) and elucidates the molecular mechanisms through which gut microbiota contribute to the formation of a tumor-permissive microenvironment, as well as facilitate malignant transformation and dissemination of tumor cells, thus mediating CRC metastasis.
Article
Biotechnology & Applied Microbiology
Jiaxin Li, Yuqi Chen, Rui Li, Xianglong Zhang, Tao Chen, Fengyi Mei, Ruofan Liu, Meiling Chen, Yue Ge, Hongbin Hu, Rongjuan Wei, Zhenfeng Chen, Hongying Fan, Zhenhua Zeng, Yongqiang Deng, Haihua Luo, Shuiwang Hu, Shumin Cai, Feng Wu, Nengxian Shi, Zhang Wang, Yunong Zeng, Ming Xie, Yong Jiang, Zhongqing Chen, Wei Jia, Peng Chen
Summary: Sepsis, a global public health challenge, lacks effective treatment or intervention. This study reveals that hyodeoxycholic acid (HDCA) has excellent anti-inflammatory properties in sepsis. HDCA administration significantly decreases systemic inflammatory responses and improves the survival of septic mice. The mechanism involves the competitive blockade of lipopolysaccharide binding to TLR4 and MD-2 receptor complex by HDCA. These findings highlight the potential value of HDCA as a therapeutic molecule for sepsis.
Review
Pharmacology & Pharmacy
Kenneth Chat Pan Cheung, Ma Jiao, Xingxuan Chen, Jia Wei
Summary: This article discusses the potential of extracellular vesicles in the treatment of osteoporosis, and introduces their characteristics and application prospects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lijuan Yu, Chunhua Huang, Wei Yang, Zhenxing Ren, Lifeng Li, Huiyuan Cheng, Chengyuan Lin, Lixiang Zhai, Ziwan Ning, Hoileong Xavier Wong, Quanbin Han, Wei Jia, Zhaoxiang Bian, Ling Zhao
Summary: This study evaluated the effect of cinnamon extract on bowel symptoms in rat models of irritable bowel syndrome with diarrhea (IBS-D). It found that cinnamon extract reduced defecation frequency and visceral hyperalgesia in the rat models, and the efficacy was comparable to a positive drug. Furthermore, cinnamon extract directly inhibited the expression of Tph1 and controlled serotonin synthesis, providing a scientific viewpoint for the traditional use of cinnamon in treating IBS.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Yu Pi, Yujun Wu, Xiangyu Zhang, Dongdong Lu, Dandan Han, Jiangchao Zhao, Xiaojiao Zheng, Shiyi Zhang, Hao Ye, Shuai Lian, Yu Bai, Zhenyu Wang, Shiyu Tao, Dongjiao Ni, Xinhua Zou, Wei Jia, Guolong Zhang, Defa Li, Junjun Wang
Summary: In this study, the difference in fecal microbiome and bile acid (BA) profiles between low birth weight (LBW) and normal birth weight (NBW) piglets were investigated. Fecal microbiota transplantation confirmed the link between microbial BA metabolism and intestinal inflammation. The therapeutic potential of ursodeoxycholic acid (UDCA) was evaluated and it was found to alleviate intestinal inflammation through M2 macrophage polarization and suppression of inflammatory cytokines.
Article
Microbiology
Lepeng Zhou, Wen Qiu, Jie Wang, Aihua Zhao, Chuhui Zhou, Tao Sun, Ziyu Xiong, Peihua Cao, Wei Shen, Jingfen Chen, Xiaolu Lai, Liu-hong Zhao, Yue Wu, Meng Li, Feng Qiu, Yanhong Yu, Zhenjiang Zech Xu, Hongwei Zhou, Wei Jia, Yan Liao, Ravi Retnakaran, Daniel Krewski, Shi Wu Wen, Jose C. Clemente, Tianlu Chen, Ri-hua Xie, Yan He
Summary: The microbiomes of cesarean-born infants differ from vaginally delivered infants and are associated with increased disease risks. Vaginal microbiota transfer (VMT) to newborns may reverse C-section-related micro biome disturbances. In this study, VMT was found to be safe and had positive effects on infant neurodevelopment, gut microbiota maturation, and fecal metabolites.
CELL HOST & MICROBE
(2023)
Review
Immunology
Kenneth C. P. Cheung, Jiao Ma, Rodrigo Azevedo Loiola, Xingxuan Chen, Wei Jia
Summary: Bile acid-activated receptors have important roles in regulating microbiota-host immunity and may influence the development of metabolic disorders. This perspective provides a summary of regulatory pathways and mechanisms of these receptors, their impact on immune system, cell proliferation, and signaling in inflammatory diseases. It also discusses new therapeutic approaches and clinical projects on bile acids for disease treatment.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D'Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino
Summary: An essential function of the epidermis is to provide a physical barrier that prevents water loss. Alteration of ceramides, cholesterol, and very long chain fatty acids, mediators of this barrier function, causes human pathologies. A study shows that genetic deletion of ZFP750 in mice leads to the loss of epidermal barrier function due to a reduction in ceramides. ZFP750 directly and/or indirectly regulates the expression of enzymes involved in ceramide biosynthesis, contributing to our understanding of skin disease pathogenesis.
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Article
Biochemistry & Molecular Biology
Claire L. K. Boulange, Helle K. Pedersen, Francois-Pierre Martin, Lea Siegwald, Albert Palleja C. Caro, Aron C. Eklund, Wei Jia, Huizhen Zhang, Bernard Berger, Norbert G. Sprenger, Ralf G. Heine, CINNAMON Study Investigator Grp
Summary: Cow's milk protein allergy (CMPA) is a common food allergy in infants and young children. A study was conducted on non-breastfed infants with CMPA to assess the effects of a whey-based extensively hydrolyzed formula (EHF) supplemented with 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) on the fecal microbiome and metabolome. The supplementation of human milk oligosaccharides (HMO) enriched bifidobacteria in the gut microbiome and delayed the shift of the microbiome composition towards an adult-like pattern. HMO supplementation partially corrected the dysbiosis commonly observed in infants with CMPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Siu Leung Chau, Aihua Zhao, Wei Jia, Lu Wang
Summary: This study presents a method for rapidly detecting pesticide residues and mycotoxins in Pu-erh tea. The results showed no pesticide residues and mycotoxins detected in the collected samples, all of which were below the legal limits.
Article
Nutrition & Dietetics
Hung N. Luu, Chi Thi-Du Tran, Renwei Wang, Mai Vu-Tuyet Nguyen, Mo Thi Tran, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Hien Huy Vu, Nam Chi Bui, Hien Thi-Thu Ha, Dung Tuan Trinh, Claire E. Thomas, Jennifer Adams-Haduch, Liudmilla Velikokhatnaya, Robert E. Schoen, Guoxiang Xie, Wei Jia, Paolo Boffetta, Jose C. Clemente, Jian-Min Yuan
Summary: The study found that colorectal advanced adenoma is associated with alterations in ileal juice bile acids. The concentrations of hyodeoxycholic acid (HCA) species in ileal juice were significantly higher in advanced adenoma patients compared to controls. The relative abundance of ursodeoxycholic acid (UDCA) in total bile acids was significantly reduced in cases than controls.
Article
Biochemical Research Methods
Kun Ge, Dan Zheng, Jieyi Wang, Wei Jia, Aihua Zhao
Summary: A simple and rapid method for quantifying ceramides and dihydroceramides in animal tissues has been developed. The results indicate significant differences in ceramide and dihydroceramide levels between liver and small intestine tissues, which may be related to the compositional features of ceramides.
ANALYTICAL BIOCHEMISTRY
(2023)