Article
Engineering, Biomedical
Yanxin Zhang, Xin Li, Zhaowenbin Zhang, Huili Li, Dongmin Chen, Yiren Jiao, Chen Fan, Zhen Zeng, Jiang Chang, Yuhong Xu, Baowei Peng, Chen Yang, Yumei Que
Summary: This study developed a Zn2SiO4 bioceramic that can release bioactive SiO32- and Zn2+ ions simultaneously, which have synergistic effects on promoting endothelial cell angiogenesis, inhibiting cardiomyocyte apoptosis, and protecting myocardial mitochondria against reactive oxygen species-induced injury. In vivo outcomes from a murine MI model demonstrated that systemic administration or local application of the Zn2SiO4 extract or composite hydrogel promoted cardiac function and reduced cardiac fibrosis, aiding myocardial repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Suet Yen Chong, Olga Zharkova, Siti Maryam J. M. Yatim, Xiaoyuan Wang, Xiong Chang Lim, Chenyuan Huang, Chia Yee Tan, Jianming Jiang, Lei Ye, Michelle Siying Tan, Veronique Angeli, Henri H. Versteeg, Mieke Dewerchin, Peter Carmeliet, Carolyn S. P. Lam, Mark Y. Chan, Dominique P. V. de Kleijn, Jiong-Wei Wang
Summary: The study found that the TF cytoplasmic domain exacerbates post-infarct cardiac injury and adverse LV remodeling by regulating inflammation and angiogenesis. Targeted inhibition of TF cytoplasmic domain-mediated intracellular signaling may ameliorate post-infarct LV remodeling.
Review
Immunology
Irina Kologrivova, Marina Shtatolkina, Tatiana Suslova, Vyacheslav Ryabov
Summary: The burden of heart failure following myocardial infarction remains a major issue in clinical practice. The failure to resolve inflammation post-myocardial injury results in unsuccessful left ventricular remodeling and contributes to heart failure pathogenesis. The immune system's role in heart remodeling is ambiguous, with both protective and damaging effects observed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jianqiu Pei, Lin Cai, Fang Wang, Chuansheng Xu, Shengqiang Pei, Hongwei Guo, Xiaogang Sun, Jerold Chun, Xiangfeng Cong, Weiquan Zhu, Zhe Zheng, Xi Chen
Summary: This study found that the level of lysophosphatidic acid (LPA) was increased in the peripheral blood of mice after myocardial infarction (MI), and the expression of its receptor LPA(2) was also increased in the heart. Deficiency of Lpar2 led to impaired heart function, increased scar size, and reduced vascular density. Mechanistic studies demonstrated that LPA-LPA(2) signaling promoted angiogenesis and maintained vascular homeostasis through multiple signaling pathways.
CIRCULATION RESEARCH
(2022)
Review
Chemistry, Medicinal
Zohreh Varasteh, Wolfgang A. Weber, Christoph Rischpler
Summary: Molecular imaging technologies play a vital role in the detection and treatment of cardiovascular disease, providing unique insights into pathobiological processes and enabling personalized therapy.
Article
Medicine, Research & Experimental
Lavinia Rech, Mahmoud Abdellatif, Verena Stangl, Nishani Mabotuwana, Sean Hardy, Peter P. Rainer, Maria Poettler
Summary: This study investigated the protective effects of pharmacologic STING inhibition after myocardial infarction. The results showed that pharmacologic STING inhibition can reduce infarct expansion and scarring, improve left ventricular systolic function, and attenuate myocardial hypertrophy. This suggests that selective small-molecule STING inhibition has the potential to improve wound healing responses and pathological remodeling after myocardial infarction.
Article
Cardiac & Cardiovascular Systems
Xueyi Chen, Pavel Zhabyeyev, Abul K. Azad, Bart Vanhaesebroeck, Chad E. Grueter, Allan G. Murray, Zamaneh Kassiri, Gavin Y. Oudit
Summary: PI3K alpha plays a crucial role in cell survival, hypertrophic response, and angiogenesis, and inhibition of PI3K alpha after myocardial infarction may result in adverse consequences.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Wenguang Chang, Peifeng Li
Summary: Myocardial injury is a leading cause of death in heart disease patients. Recent studies have shown that mesenchymal stromal cells (MSCs) and their secretomes, specifically small extracellular vesicles (sEVs), have therapeutic effects on cardiac injury. MSCs are able to differentiate into various cell types, making them suitable for cardiac repair, but sEVs have shown better therapeutic effects and easier quality control. This review summarizes the current knowledge and discusses scientific issues in the development of MSC and MSC-sEV-based therapies for cardiac injury.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Yuejun Yao, Aoqi Li, Shuqin Wang, Yuwen Lu, Jieqi Xie, Haolan Zhang, Deteng Zhang, Jie Ding, Zhaoyi Wang, Chenxi Tu, Liyin Shen, Lenan Zhuang, Yang Zhu, Changyou Gao
Summary: Myocardial infarction (MI) is a major cause of death and disability globally. A multifunctional cardiac patch has been developed to provide mechanical support to the infarcted myocardium and improve therapeutic outcomes by mediating biological and mechanical treatments.
Article
Multidisciplinary Sciences
Masashi Tomimatsu, Kotaro Matsumoto, Moe Ashizuka, Shohei Kumagai, Shota Tanaka, Takafumi Nakae, Kosei Yokota, Shunsuke Kominami, Ryota Kajiura, Daisuke Okuzaki, Daisuke Motooka, Aki Shiraishi, Takaya Abe, Hideo Matsuda, Yoshiaki Okada, Makiko Maeda, Shigeto Seno, Masanori Obana, Yasushi Fujio
Summary: Runx2 plays an important role in cardiac remodeling after myocardial infarction, with its deficiency leading to cardiac dysfunction and exacerbated fibrosis, possibly through regulating endothelial cell function.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Yuan Tian, Zilin Wang, Feng Liang, Yi Wang
Summary: This study aimed to identify the hub differential expression genes (DEGs) of myocardial remodeling after myocardial infarction (MI) and determine the distribution of immune cells infiltrating the pathology. Four hub genes (P3H3, COL15A1, COL16A1, COL27A1), especially P3H3, were identified as potential targets for targeted therapy in MI patients.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Wei Chen, Changyong Wang, Wei Liu, Bicheng Zhao, Zhicheng Zeng, Fen Long, Chunlan Wang, Siwei Li, Naibo Lin, Jin Zhou
Summary: Injectable hydrogels carrying therapeutic factors show potential in MI treatment. A new hydrogel system, MPGC4, is developed to release therapeutic factors in a controlled manner. It improves cardiac function by modulating macrophage transition in a rat model of MI.
ADVANCED MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Yu Huang, Liangpeng Li, Hongmei Chen, Qiao Liao, Xiaoli Yang, Dezhong Yang, Xuewei Xia, Hongyong Wang, Wei Eric Wang, Lianglong Chen, Chunyu Zeng
Summary: YY1 expression in the heart was significantly stimulated following myocardial infarction. Overexpression of YY1 improved survival rate, cardiac function, scar size, and left ventricular volume in mice, while silencing YY1 had the opposite effects. YY1 alleviated cardiac apoptosis and fibrosis, promoted angiogenesis, T helper 2 cytokine production, M2 macrophage polarization, and enhanced endothelial cell tube formation and migration ability. Enhanced Akt phosphorylation and vascular endothelial growth factor production were observed in the presence of YY1 overexpression. These effects suggest YY1 as a potential therapeutic target for myocardial infarction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Bin Zeng, Xiaoting Liao, Lei Liu, Caixia Zhang, Huaiyu Ruan, Bo Yang
Summary: The study found that T3 pretreatment significantly reduces myocardial infarct area, inhibits cardiomyocyte apoptosis and fibrosis, and improves left ventricular function post-MI. Furthermore, T3 can also promote angiogenesis, reduce inflammatory cytokines, and protect the heart from damage after MI.
Article
Cell Biology
Chuiyu Kong, Dayin Lyu, Chang He, Rui Li, Qiulun Lu
Summary: Studies have shown that Dioscin significantly improves cardiac function in mouse models of myocardial infarction, reduces cardiac fibrosis and apoptosis, and promotes angiogenesis. Mechanistically, Dioscin enhances the proliferation and migration of hypoxic endothelial cells by up-regulating lncRNA MANTIS, leading to the induction of angiogenesis-related genes. This provides new insights into the cardioprotective effects of Dioscin and its impact on endothelial cell angiogenic activity.
Editorial Material
Allergy
Azahara Lopez-Raigada, de la Osada F. Vega, C. Lopez-Sanz, Garcia M. Mugica, A. Alfranca, C. Blanco
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Marta Calvet-Mirabent, Daniel T. Claiborne, Maud Deruaz, Serah Tanno, Carla Serra, Cristina Delgado-Arevalo, Ildefonso Sanchez-Cerrillo, Ignacio de Los Santos, Jesus Sanz, Lucio Garcia-Fraile, Francisco Sanchez-Madrid, Arantzazu Alfranca, Maria Angeles Munoz-Fernandez, Todd M. Allen, Maria J. Buzon, Alejandro Balazs, Vladimir Vrbanac, Enrique Martin-Gayo
Summary: The combination of 2‘3’-c ' diAM(PS)2 and Poly I:C as adjuvants can enhance DCs' ability to induce polyfunctional HIV-1 specific CD8(+) T-cell responses, reducing the severity of CD4(+) T-cell depletion following HIV-1 infection, and preserving the specific polyfunctional responses of CD8(+) T cells. The priming of DCs with PolyI:C and STING agonists may be useful for future HIV-1 vaccine studies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Pedro Martinez-Fleta, Paula Vera-Tome, Maria Jimenez-Fernandez, Silvia Requena, Emilia Roy-Vallejo, Ancor Sanz-Garcia, Marta Lozano-Prieto, Celia Lopez-Sanz, Alicia Vara, Angel Lancho-Sanchez, Enrique Martin-Gayo, Cecilia Munoz-Calleja, Arantzazu Alfranca, Isidoro Gonzalez-Alvaro, Jose Maria Galvan-Roman, Javier Aspa, Hortensia de la Fuente, Francisco Sanchez-Madrid
Summary: This study compared plasma miRNA and cytokine profiles between COVID-19 and other community-acquired pneumonias (CAP), revealing 15 dysregulated miRNAs and differential cytokine signatures. These findings provide new insights into the etiopathological mechanisms of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Alvaro Fernando Garcia-Jimenez, Yaiza Caceres-Martell, Daniel Fernandez-Soto, Pedro Martinez Fleta, Jose M. Casasnovas, Francisco Sanchez-Madrid, Jose Miguel Rodriguez Frade, Mar Vales-Gomez, Hugh T. Reyburn
Summary: Several unanswered questions remain about humoral and cellular immunity to SARS-CoV-2, including whether preexisting memory T or B cells in unexposed individuals can recognize and suppress COVID-19. Research has shown that while some unexposed individuals have cross-reactive T cell responses, these responses are weak in aspects like T-FH expansion, which may impact the generation of effective antibodies against SARS-CoV-2. Understanding these differences in cellular responses is crucial for advancing our knowledge of immunity to SARS-CoV-2.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Eva M. Garcia-Cuesta, Jose Miguel Rodriguez-Frade, Sofia R. Gardeta, Gianluca D'Agostino, Pablo Martinez, Blanca Soler Palacios, Graciela Cascio, Tobias Wolf, Nicolas Mateos, Rosa Ayala-Bueno, Cesar A. Santiago, Pilar Lucas, Lucia Llorente, Luis M. Allende, Luis Ignacio Gonzalez-Granado, Noa Martin-Cofreces, Pedro Roda-Navarro, Federica Sallusto, Francisco Sanchez-Madrid, Maria F. Garcia-Parajo, Laura Martinez-Munoz, Mario Mellado
Summary: This study reveals that the truncated mutant chemokine receptor CXCR4(R334X) associated with WHIM syndrome fails to nanoclusterize after CXCL12 stimulation, affecting cell spatial organization and mobility, and causing multiple phalloidin-positive protrusions in cells. The inappropriate activation of beta-arrestin1 by CXCR4(R334X) leads to inadequate actin cytoskeleton remodeling, disrupting the balance between activated and deactivated cofilin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Alberto Cecconi, Gonzalo Navarrete, Marcos Garcia-Guimaraes, Alberto Vera, Rafael Blanco-Dominguez, Ancor Sanz-Garcia, Marta Lozano-Prieto, Beatriz Lopez-Melgar, Fernando Rivero, Pilar Martin, Francisco Sanchez-Madrid, Hortensia de la Fuente, Luis Jesus Jimenez-Borreguero, Fernando Alfonso
Summary: This study aimed to assess the inflammatory changes in circulating immune cells and microRNAs in myocardial infarction (MI) patients related to short-term exposure to air pollutants. The results showed that short-term exposure to PM2.5 was associated with a reduction in CD4(+) regulatory T cells, as well as an increase in miR-146a-5p and miR-423-3p in ST-segment elevation myocardial infarction (STEMI) patients. Additionally, PM2.5 exposure was associated with an increase in miR-let-7f-5p in STEMI and non-ST-segment elevation myocardial infarction (NSTEMI) patients.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Alberto Cecconi, Pablo Martinez-Vives, Alberto Vera, Cristina Lavilla Olleros, Ana Barrios, Eva Fonseca Aizpuru, Pilar Roquero, Susana Hernandez Muniz, Maria Jose Olivera, Marianela Ciudad, Ruben Pampin Sanchez, Rosa Fernandez-Madera Martinez, Azucena Bautista-Hernandez, Elena Garcia Castillo, Gorane Iturricastillo, Elena Avalos, Diana Prada Cotado, Alvaro Alejandre de Ona, Eduardo Fernandez Carracedo, Ana Marcos-Jimenez, Ancor Sanz-Garcia, Aranzazu Alfranca, Maurizio Cecconi, Hortensia de la Fuente, Maria Angeles Sanz de Benito, Paloma Caballero, Francisco Sanchez-Madrid, Julio Ancochea, Carmen Suarez, Luis Jesus Jimenez-Borreguero, Fernando Alfonso
Summary: In a trial investigating the use of colchicine for COVID-19 pneumonia patients, no significant clinical benefit was observed compared to standard care.
SCIENTIFIC REPORTS
(2022)
Review
Allergy
Nieves Fernandez-Gallego, Raquel Castillo-Gonzalez, Nerea Mendez-Barbero, Celia Lopez-Sanz, David Obeso, Alma Villasenor, Maria M. Escribese, Beatriz Lopez-Melgar, Jorge Salamanca, Amparo Benedicto-Buendia, Luis Jesus Jimenez-Borreguero, Borja Ibanez, Joaquin Sastre, Maria Teresa Belver, Francisco Vega, Carlos Blanco, Domingo Barber, Francisco Sanchez-Madrid, Hortensia de la Fuente, Pilar Martin, Vanesa Esteban, Rodrigo Jimenez-Saiz
Summary: Allergic diseases and atherosclerosis are two different types of immune disorders, and they have a complex clinical association and mutual influence.
Article
Biochemistry & Molecular Biology
Maria Jimenez-Fernandez, Cristina Rodriguez-Sinovas, Laia Canes, Carme Ballester-Servera, Alicia Vara, Silvia Requena, Hortensia de la Fuente, Jose Martinez-Gonzalez, Francisco Sanchez-Madrid
Summary: The mechanisms controlling the inflammatory-immune response are vital in tissue remodelling in cardiovascular diseases. CD69, a T-cell activation receptor, binds to oxidized low-density lipoprotein (oxLDL) and induces the expression of anti-inflammatory NR4A nuclear receptors and modulates inflammation in atherosclerosis. This study reveals a novel mechanism of PD-1 induction independent of TCR signalling, which may contribute to CD69's modulation of inflammation and vascular remodelling in cardiovascular diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Laura Esparcia-Pinedo, Ayla Yarci-Carrion, Gloria Mateo-Jimenez, Noelia Ropero, Laura Gomez-Cabanas, Angel Lancho-Sanchez, Patricia Almendro-Vazquez, Enrique Martin-Gayo, Estela Paz-Artal, Francisco Sanchez-Madrid, Fernando Moldenhauer, Ainhoa Gutierrez-Cobos, Diego Real de Asua, Arantzazu Alfranca
Summary: This study found that individuals with Down syndrome (DS) develop an effective immune response to SARS-CoV-2 vaccination. The cellular and humoral responses to the vaccine were observed in DS individuals after 1 to 3 months and 6 months, with an effective immune response observed in 98% of DS individuals after 6 months.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Pablo F. Cespedes, Ashwin Jainarayanan, Lola Fernandez-Messina, Salvatore Valvo, David G. Saliba, Elke Kurz, Audun Kvalvaag, Lina Chen, Charity Ganskow, Huw Colin-York, Marco Fritzsche, Yanchun Peng, Tao Dong, Errin Johnson, Jesus A. Siller-Farfan, Omer Dushek, Erdinc Sezgin, Ben Peacock, Alice Law, Dimitri Aubert, Simon Engledow, Moustafa Attar, Svenja Hester, Roman Fischer, Francisco Sanchez-Madrid, Michael L. Dustin
Summary: The authors use bead-supported lipid bilayers as synthetic APCs to show that trans-synaptic vesicles produced by T cells in the immunological synapse carry specialized cargos distinct from constitutive extracellular vesicles to serve as intercellular messengers.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Sara G. Dosil, Sheila Lopez-Cobo, Ana Rodriguez-Galan, Irene Fernandez-Delgado, Marta Ramirez-Huesca, Paula Milan-Rois, Milagros Castellanos, Alvaro Somoza, Manuel Jose Gomez, Hugh T. Reyburn, Mar Vales-Gomez, Francisco Sanchez Madrid, Lola Fernandez-Messina
Summary: NK cells and their secreted EVs have immunomodulatory roles, promoting Th1 responses and activating monocytes and moDCs. MicroRNAs of NK-EVs target molecules involved in Th1 responses and partially recapitulate their effects in mice.
Article
Medicine, General & Internal
Marta Calvet-Mirabent, Ildefonso Sanchez Cerillo, Noa Martin-Corfrees, Pedro Martinez-Fleta, Hortensia de la Fuente, Ilya Tsukalov, Cristina Delgado-Arevelo, Maria Jose Calzo, Ignaciode de los Santos, Jesus Sanz, Lucio Garcia-Fraile, Francisco Sanchez Madid, Arantzazu Alfranca, Maria Angles Munoz-Ferandez, Maria J. Buzon, Enrique Martin-Gayo
Summary: This study identifies specific immunometabolic parameters associated with functional restoration of CD8+ T cells in people living with HIV-1 on long-term ART. The findings suggest that CD8+ T cells from these patients show improved polyfunctionality and capacity to eliminate infected CD4+ T cells after treatment with Gag-adjuvant-primed DC. However, CD8+ T cells from patients on short-term ART show limited functional improvement after DC treatment, which is associated with altered memory cell subsets, increased expression of PD1 and TIGIT, and reduced metabolic activity upon TCR activation. Restoring the function of CD8+ T cells from these patients can be achieved through combined treatment with anti-PD1 and anti-TIGIT antibodies and a glycolysis promoting drug.
Article
Oncology
Jacobo Rogado, Fernando Pozo, Kevin Troule, Jose Miguel Sanchez-Torres, Nuria Romero-Laorden, Rebeca Mondejar, Olga Donnay, Anabel Ballesteros, Vilma Pacheco-Barcia, Javier Aspa, Fatima Al-Shahrour, Arantzazu Alfranca, Ramon Colomer
Summary: Peripheral blood mononuclear cells (PBMCs) have been explored as potential biomarkers to predict the efficacy of anti-PD-1 immunotherapy in advanced non-small cell lung cancer (NSCLC) patients. High baseline levels of circulating T cell subpopulations related to tissue lymphocyte recruitment were found to be associated with poorer outcomes in immunotherapy-treated advanced NSCLC patients.