Review
Dentistry, Oral Surgery & Medicine
Jovania Alves Oliveira, Roberta de Oliveira Alves, Isabella Mazarelo Nascimento, Marco Antonio Rimachi Hidalgo, Raquel Mantuaneli Scarel-Caminaga, Suzane Cristina Pigossi
Summary: This study aimed to review the levels of pro- and anti-inflammatory cytokines and osteoclastogenesis-related factors in peri-implant diseases. The results showed that the levels of IL-1β, IL-6, IL-10, and RANKL/OPG were not balanced in peri-implant diseases, suggesting their involvement in the host response related to peri-implantitis.
Review
Infectious Diseases
Asma Gasmi Benahmed, Amin Gasmi, Torsak Tippairote, Pavan Kumar Mujawdiya, Oleksandr Avdeev, Yurii Shanaida, Geir Bjorklund
Summary: Dental implants are commonly used to replace lost teeth, and titanium implants have a high success rate. However, there is an increasing risk of peri-implantitis, an inflammatory disease that affects the tissues around the implant. This review highlights the impact of different metabolic conditions on peri-implantitis and emphasizes the importance of considering both local and systemic factors in dental implant procedures and treatment.
Article
Dentistry, Oral Surgery & Medicine
Mario Romandini, Jessica Berglundh, Jan Derks, Mariano Sanz, Tord Berglundh
Summary: The study aimed to evaluate the diagnostic accuracy of clinical and radiographic evaluations made at a single time point during follow-up. The bone levels observed at 9 years were highly accurate in identifying pronounced bone loss. In the absence of baseline documentation, a secondary case definition based on clinical findings provided the best overall diagnostic accuracy in identifying peri-implantitis cases.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
Pedro Diaz, Esther Gonzalo, Luis J. Gil Villagra, Barbara Miegimolle, Maria J. Suarez
Summary: This systematic review estimates the overall prevalence of peri-implantitis and explores the impact of different study designs, function times, and use of probing depth on the prevalence rate. The results show that the prevalence of peri-implantitis is highly variable and the use of probing depth as a diagnostic criterion affects the prevalence data. It is important to identify diagnostic markers for more accurate disease classification.
Review
Medicine, Research & Experimental
Carlos Henrique Alves, Karolayne Larissa Russi, Natalia Conceicao Rocha, Fabio Bastos, Michelle Darrieux, Thais Manzano Parisotto, Raquel Girardello
Summary: In recent decades, there have been significant advances in ortho-aesthetic-functional rehabilitation with the introduction of implantology. However, there is still a percentage of failures in implantology surgeries, mainly due to infections caused by bacterial proliferation, fungi presence, and biofilm formation, leading to peri-implantitis. Various studies have been conducted to explore the interaction between the host-oral microbiome and the development of peri-implantitis. Peri-implantitis is associated with a diversity of bacterial species, with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia being identified in higher proportions of peri-implantitis samples. In addition, the injury of peri-implant tissue triggers an inflammatory response mediated by the activation of innate immune cells, such as macrophages, dendritic cells, mast cells, and neutrophils. Activation of the host immune system may disrupt the balance of oral microbiota, leading to dysbiosis and the production of various substances that contribute to implant loss.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Iva Milinkovic, Ana Djinic Krasavcevic, Nadja Nikolic, Zoran Aleksic, Jelena Carkic, Marija Jezdic, Sasha Jankovic, Jelena Milasin
Summary: This study aimed to compare the levels of Notch signaling pathway, bone remodeling mediators, and pro-inflammatory cytokines in peri-implantitis patients and healthy implants. The results showed that down-regulation of Notch 1 and increased expression of inflammation modulators in peri-implantitis may lead to increased osteoclast activity and subsequent bone resorption.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Muhammad H. A. Saleh, Hadiya Khurshid, Suncica Travan, Khaled Sinjab, Ali Bushahri, Hom-Lay Wang
Summary: The study found that implants placed in sites with a history of apical surgery do not have an increased risk of implant failure or retrograde peri-implantitis. The incidence of RPI was 20%, with an increased trend in cases of persistent apical periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Medicine, General & Internal
Andrea Roccuzzo, Alexandra Stahli, Alberto Monje, Anton Sculean, Giovanni E. Salvi
Summary: Dental implants are considered a reliable routine procedure for replacing missing teeth, but the presence of peri-implantitis has become a concern due to its negative impact on patients' quality of life. The surgical therapeutic modalities for managing this disorder include indications, contraindications, complexity, predictability, and effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
J. Martinez-Amargant, B. de Tapia, A. Pascual, J. Takamoli, C. Esquinas, J. Nart, C. Valles
Summary: This study aimed to determine the association between tobacco and peri-implant diseases and investigate patient- and implant-related variables associated with peri-implant diseases. Data from 117 patients treated with implant-supported restorations were analyzed, and the study found that smoke intensity was associated with an increased risk of peri-implant diseases.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Karin Apaza-Bedoya, Maria Elisa Galarraga-Vinueza, Bruna Barbosa Correa, Frank Schwarz, Marco Aurelio Bianchini, Cesar Augusto Magalhaes Benfatti
Summary: This study assessed the prevalence and risk indicators of peri-implant diseases, and associated specific clinical characteristics with these diseases. In the medium term, peri-implant diseases were correlated with factors inherent to the patient's conditions, presurgical treatment plan, and hygiene maintenance care.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Andrea Roccuzzo, Jean-Claude Imber, Giovanni Edoardo Salvi, Mario Roccuzzo
Summary: Peri-implantitis is a common disease characterized by inflammation in the tissues around dental implants, leading to bone loss. Nonideal conditions in implant therapy, such as poor planning and insufficient periodontal therapy, may contribute to its progression. There is a good level of evidence for certain factors, while more research is needed to identify others and their long-term impact on peri-implantitis.
PERIODONTOLOGY 2000
(2023)
Article
Dentistry, Oral Surgery & Medicine
Himabindu Dukka, Muhammad H. A. Saleh, Andrea Ravida, Henry Greenwell, Hom-Lay Wang
Summary: Bleeding on probing (BOP) is an indispensable diagnostic tool for evaluating periodontal disease, but its role in peri-implant disease is more complex. The confusion in interpretation is due to differences in how BOP originates and is used in implants. A comprehensive bleeding index and other parameters should be used together for diagnosing peri-implant diseases accurately.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alberto Monje, Maria Vera, Agustin Munoz-Sanz, Hom-Lay Wang, Jose Nart
Summary: This study investigated the characteristics related to SUP around dental implants and found that the presence and grade of SUP were associated with the prevalence of peri-implantitis and implant features, indicating a close relationship between SUP and the clinical manifestations and influencing factors of peri-implantitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Wonsup Lee, Jun-Beom Park
Summary: The aim of this study was to evaluate the clinical effects of sodium hypochlorite oral rinse on peri-implantitis lesions. The results showed a decrease in probing depth and modified sulcular bleeding index after 3 months of using the rinse. The study suggested that a concentration of 0.25% be used for treating peri-implantitis.
Article
Dentistry, Oral Surgery & Medicine
Marija Jezdic, Nadja Nikolic, Ana Djinic Krasavcevic, Jelena Milasin, Zoran Aleksic, Jelena Carkic, Sasha Jankovic, Iva Milinkovic
Summary: The study aimed to evaluate the prevalence of specific microbiota and their correlation with clinical parameters, proinflammatory cytokines, Notch signaling pathway molecules, and bone remodeling mediators in different peri-implant conditions. The prevalence of P. gingivalis, Fusobacterium spp., EBV, and C. albicans was assessed in participants' crevicular fluid, and their presence was correlated with markers' expression and clinical data. The results showed a higher prevalence of P. gingivalis and Fusobacterium spp. in peri-implantitis and peri-implant mucositis groups compared to healthy implants, suggesting their potential involvement in osteolysis and disease progression.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hagai Hazan-Molina, Yankel Gabet, Itay Aizenbud, Nitzan Aizenbud, Dror Aizenbud
Summary: The study found that in a rat model, the addition of ESWT to orthodontic force after three weeks more than doubled the average tooth movement. ESWT application on the pressure side led to a significant decrease in volumetric bone mineral density. Blood vessel density and the number of TRAP positive cells increased after ESWT application.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zamzam Awida, Almog Bachar, Hussam Saed, Anton Gorodov, Nathalie Ben-Califa, Maria Ibrahim, Albert Kolomansky, Jennifer Ana Iden, Liad Graniewitz Visacovsky, Tamar Liron, Sahar Hiram-Bab, Michael Brines, Yankel Gabet, Drorit Neumann
Summary: The study shows that Cibinetide (CIB) can increase bone density and inhibit osteoclastogenesis in mice, suggesting it as a potential candidate for the treatment of bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Biomaterials
Idan Redenski, Shaowei Guo, Majd Machour, Ariel Szklanny, Shira Landau, Dana Egozi, Yankel Gabet, Shulamit Levenberg
Summary: This study focuses on exploring and analyzing vascular networks within newly formed tissues using contrast agent perfusion protocol and high-resolution microCT technology, aiming to study the formation and function of new blood vessels. By conducting experiments in a rat femoral bundle model, a comprehensive method for understanding vessel organization during tissue engraftment and development is proposed.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Nathan E. Reticker-Flynn, Weiruo Zhang, Julia A. Belk, Pamela A. Basto, Nichole K. Escalante, Genay O. W. Pilarowski, Alborz Bejnood, Maria M. Martins, Justin A. Kenkel, Ian L. Linde, Sreya Bagchi, Robert Yuan, Serena Chang, Matthew H. Spitzer, Yaron Carmi, Jiahan Cheng, Lorna L. Tolentino, Okmi Choi, Nancy Wu, Christina S. Kong, Andrew J. Gentles, John B. Sunwoo, Ansuman T. Satpathy, Sylvia K. Plevritis, Edgar G. Engleman
Summary: Lymph node metastasis plays an active role in shaping distant metastasis in solid malignancies, and this mechanism involves the evasion of immune cells, colonization in lymph nodes, and subsequent colonization in other tissues. This mechanism is conserved in human cancers and murine cancer models.
Article
Biology
Bitya Raphael-Mizrahi, Malka Attar-Namdar, Mukesh Chourasia, Maria G. Cascio, Avital Shurki, Joseph Tam, Moshe Neuman, Neta Rimmerman, Zvi Vogel, Arie Shteyer, Roger G. Pertwee, Andreas Zimmer, Natalya M. Kogan, Itai Bab, Yankel Gabet, Mone Zaidi
Summary: The endocannabinoid system, consisting of OGP and CB2, plays an important role in maintaining bone health and preventing age-related bone loss. OGP acts as an agonist and positive allosteric modulator of CB2, and its decrease in circulation with age is associated with bone loss in premenopausal women and adult mice.
Article
Medicine, Research & Experimental
Reem Abu-Kheit, Shlomo Kotev-Emeth, Sahar Hiram-Bab, Yankel Gabet, Naphtali Savion
Summary: This study demonstrates that ASSNAC can protect bone marrow cells from oxidative stress and may improve bone microarchitecture in adult healthy and diabetic female mice.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Alessio D. Nahmad, Cicera R. Lazzarotto, Natalie Zelikson, Talia Kustin, Mary Tenuta, Deli Huang, Inbal Reuveni, Daniel Nataf, Yuval Raviv, Miriam Horovitz-Fried, Iris Dotan, Yaron Carmi, Rina Rosin-Arbesfeld, David Nemazee, James E. Voss, Adi Stern, Shengdar Q. Tsai, Adi Barzel
Summary: In vivo engineering of B cells to secrete anti-HIV antibodies is a safe, potent, and scalable method that can be used for the treatment of infectious and noncommunicable diseases.
NATURE BIOTECHNOLOGY
(2022)
Article
Biology
Amit Gutwillig, Nadine Santana-Magal, Leen Farhat-Younis, Diana Rasoulouniriana, Asaf Madi, Chen Luxenburg, Jonathan Cohen, Krishnanand Padmanabhan, Noam Shomron, Guy Shapira, Annette Gleiberman, Roma Parikh, Carmit Levy, Meora Feinmesser, Dov Hershkovitz, Valentina Zemser-Werner, Oran Zlotnik, Sanne Kroon, Wolf-Dietrich Hardt, Reno Debets, Nathan Edward Reticker-Flynn, Peleg Rider, Yaron Carmi
Summary: Despite the successes of cancer immunotherapies, many patients experience partial response and relapse due to treatment resistance. This study reveals a previously unknown resistance mechanism where tumor cells form unique cell-in-cell structures to evade immunotherapy. Inhibiting specific factors involved in this process improves therapeutic efficacy.
Article
Nutrition & Dietetics
Norman B. Gaylis, Ida Kreychman, Joanne Sagliani, Josef Mograbi, Yankel Gabet
Summary: The combination of beta-caryophyllene and pregnenolone shows significant synergistic effects in resolving sepsis and inflammation in mice. Researchers designed a unique dietary supplement formulation by combining these compounds with seven others to alleviate inflammatory and neurological disorders caused by long COVID.
FRONTIERS IN NUTRITION
(2022)
Meeting Abstract
Hematology
Albert Kolomansky, Anton Gorodov, Stav Kislev, Nathalie Ben-Califa, Alana Starr, Yankel Gabet, Martina Rauner, Ben Wielockx, Moshe Mittelman, Howard S. Oster, Drorit Neumann
Article
Biochemistry & Molecular Biology
Jennifer Ana Iden, Bitya Raphael-Mizrahi, Aaron Naim, Albert Kolomansky, Tamar Liron, Drorit Neumann, Marilena Vered, Yankel Gabet
Summary: Five million cases of non-melanoma skin cancer occur globally each year, and the dysregulation of the endocannabinoid system, particularly CB2, is implicated in its development. In this study, CB2(-/-) mice were found to have an increased incidence of spontaneous skin lesions and larger papillomas in a chemical carcinogenesis model compared to WT mice. The altered immune profile and higher expression of CB2 in carcinogen-exposed skin suggest that CB2 plays an anti-tumorigenic role through immune-mediated response and modulation of keratinocyte activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jennifer Ana Iden, Bitya Raphael-Mizrahi, Zamzam Awida, Aaron Naim, Dan Zyc, Tamar Liron, Melody Kasher, Gregory Livshits, Marilena Vered, Yankel Gabet
Summary: The role of CB2 in potentiating the immune response in colon cancer was investigated in mice and the influence of CNR2 variants in humans was determined. The study found that CB2 deficiency increased the incidence of precancerous lesions and worsened tumorigenesis in mice. Furthermore, genomic data revealed a significant association between CNR2 variants and colon cancer incidence in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Uriel Kaspersky, Roei Levy, Aysar Nashef, Fuad A. A. Iraqi, Yankel Gabet
Summary: This study assessed the heritability and genetic variation effect, as well as the sex effect on calvarial bone thickness and calvarial porosity using the Collaborative Cross (CC) mouse population. The results showed significant differences in bone thickness and porosity among CC lines, with a high heritability. It was also found that the sex effect on these parameters depended on the genetic background.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zamzam Awida, Sahar Hiram-Bab, Almog Bachar, Hussam Saed, Dan Zyc, Anton Gorodov, Nathalie Ben-Califa, Sewar Omari, Jana Omar, Liana Younis, Jennifer Ana Iden, Liad Graniewitz Visacovsky, Ida Gluzman, Tamar Liron, Bitya Raphael-Mizrahi, Albert Kolomansky, Martina Rauner, Ben Wielockx, Yankel Gabet, Drorit Neumann
Summary: This study demonstrates that EPOR in the monocytic lineage is at least partially responsible for the effect of EPO on bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Y. Carmi
HUMAN GENE THERAPY
(2022)