期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02653
关键词
invariant natural killer T cells; CD1d; autophagy; thymic development; metabolic switch
类别
资金
- NIH [DK104817]
- NIFA [2016-09448]
- NICHD [HD092286]
- Department of Defense [W81XWH-15-1-0543]
- National Multiple Sclerosis Society [60006625]
- Crohn's and Colitis Foundation of America [326979]
CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) alpha-chain and recognize self and foreign glycolipid antigens. They can rapidly respond to agonist activation and stimulate an extensive array of immune responses. Thymic development and function of iNKT cells are regulated by many different cellular processes, including autophagy, a self-degradation mechanism. In this mini review, we discuss the current understanding of how autophagy regulates iNKT cell development and effector lineage differentiation. Importantly, we propose that iNKT cell development is tightly controlled by metabolic reprogramming.
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