Review
Biochemistry & Molecular Biology
Tamas Roeszer
Summary: Breastfeeding is a unique behavior of mammals, providing heat and metabolic fuel for offspring. The lipid signals in breast milk play a crucial role in infant lipid metabolism and metabolic development.
Review
Biochemistry & Molecular Biology
Bertrand Kaeffer
Summary: Breast milk contains various endogenous miRNAs, which play important roles in milk regulation and transmission through different mechanisms. Some miRNAs are found to have effects on offspring phenotypes and stimulate the immune system. Understanding the bioavailability of miRNAs is crucial for further understanding their regulatory mechanisms and potential applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Anoud Duale, Parul Singh, Souhaila Al Khodor
Summary: Breast milk contains various microorganisms that play a crucial role in the development of infant's immune system and gut microbiota, reducing the risk of chronic diseases in later life.
FRONTIERS IN NUTRITION
(2022)
Review
Medicine, Research & Experimental
Dan Li, Yujuan Li, Shengjie Yang, Jing Lu, Xiao Jin, Min Wu
Summary: The prevalence of metabolic diseases, such as obesity, type 2 diabetes, and nonalcoholic fatty liver disease, is closely related to environmental factors like diet and gut microbiota, as well as epigenetic modifications. Dietary components and habits can regulate the changes in gut microbiota, while microbiota-derived metabolites may play a role in the regulation of epigenetic modifications. These epigenetic changes mediated by microbial metabolites participate in metabolic disorders through alterations in intestinal permeability, immune responses, inflammatory reactions, and insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Ma'mon M. Hatmal, Mohammad A. I. Al-Hatamleh, Amin N. Olaimat, Walhan Alshaer, Hanan Hasan, Khaled A. Albakri, Enas Alkhafaji, Nada N. Issa, Murad A. Al-Holy, Salim M. Abderrahman, Atiyeh M. Abdallah, Rohimah Mohamud
Summary: Human breast milk contains not only nutritional components but also abundant microRNAs, which can impact epigenetic mechanisms and regulate immune and physiological functions. Studying the microRNA composition of human breast milk is important for improving nutrition during pregnancy and infancy and preventing future diseases.
Review
Immunology
Cristina Kalbermatter, Nerea Fernandez Trigo, Sandro Christensen, Stephanie C. Ganal-Vonarburg
Summary: The innate immune system is the oldest protection strategy conserved across all organisms, providing a fast defense mechanism against pathogens. The interaction between maternal immune cells, antibodies, dietary antigens, and microbial metabolites is crucial for preparing the newborn's immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Davide Gabellini, Simona Pedrotti
Summary: This review focuses on histone methyltransferases SUV4-20H1 and SUV4-20H2, which catalyze H4K20 di- and tri-methylation, and their roles in various biological processes such as DNA repair, cell cycle regulation, and DNA replication. It also outlines the pathological conditions associated with H4K20me2/3 misregulation due to mutations or aberrant expression of SUV4-20H1 or SUV4-20H2, and critically analyzes the data supporting these functions for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Marcella Bonanomi, Noemi Salmistraro, Giulia Fiscon, Federica Conte, Paola Paci, Valentina Bravata, Giusi Irma Forte, Tatiana Volpari, Manuela Scorza, Fabrizia Mastroianni, Stefano D'Errico, Elenio Avolio, Gennaro Piccialli, Anna Maria Colangelo, Marco Vanoni, Daniela Gaglio, Lilia Alberghina
Summary: The study highlights the critical role of NADH in the epigenetic landscape mediated by CtBP2 activation, linking metabolism to epigenetic transcriptional reprogramming. Through metabolomics and transcriptomics integration, it is shown that down-regulation of CtBP2 significantly reduces cell proliferation by modulating various factors, providing evidence for the crosstalk between metabolism and the transcriptional program in cancer cells.
Article
Nutrition & Dietetics
Hong-Ren Yu, Te-Yao Hsu, Ching-Chang Tsai, Hsin-Chun Huang, Hsin-Hsin Cheng, Yun-Ju Lai, Yu-Ju Lin, Chih-Cheng Chen, Sung-Chou Li, Kuender Yang
Summary: l-Arginine has a significant impact on the DNA methylation profiles of CD4(+) T cells in neonates, leading to differences in gene activation and immune function compared to adults. Supplementation of l-arginine can modulate immune-related pathways in neonatal T cells and enhance IL-13 gene expression and cytokine production through hypomethylation of CpG dinucleotides. This study suggests that nutritional intervention with l-arginine could be a potential strategy to enhance immune function in neonates by targeting gene-specific DNA methylation.
Article
Chemistry, Applied
A. Arias-Borrego, I Velasco, J. L. Gomez-Ariza, T. Garcia-Barrera
Summary: The study found that several metabolites in the breast milk of iodine-deficient women were altered, affecting metabolic pathways such as lipid metabolism, amino acid cycle, the tricarboxylic acid cycle, and glycolysis. Additionally, the concentrations of selenium, zinc, and copper were significantly lower in the breast milk of iodine-deficient women.
Article
Pharmacology & Pharmacy
Jan Nevoral, Jirina Havrankova, Yaroslav Kolinko, Sarka Prokesova, Tereza Fenclova, Ladan Monsef, Tereza Zalmanova, Jaroslav Petr, Milena Kralickova
Summary: Research shows that BPA analogues BPS and BPF have deleterious effects on reproduction, potentially affecting the quality of offspring oocytes during breastfeeding. While the ovarian histology remains unaffected, there are alterations in spindle formation and epigenetic markers. The sensitivity of in-vitro matured oocytes to BPS and BPF is significantly noted, impacting developmental competence.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Mia M. Keady, Randall R. Jimenez, Morgan Bragg, Jenna C. P. Wagner, Sally L. Bornbusch, Michael L. Power, Carly R. Muletz-Wolz
Summary: Milk production is an ancient adaptation in mammals, and milk contains a microbiome that can affect the health and development of offspring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Sayani Patra, Naveed Elahi, Aaron Armorer, Swathi Arunachalam, Joshua Omala, Iman Hamid, Anthony W. Ashton, David Joyce, Xuanmao Jiao, Richard G. Pestell
Summary: Recent studies have shown that metabolic heterogeneity occurs at various levels within tumors, impacting tumor progression and response to treatment. Understanding the complex interactions between metabolic properties, oncogenes, and the tumor microenvironment is crucial for developing more effective personalized treatments for cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Food Science & Technology
Jean-Pierre Chouraqui
Summary: Human milk oligosaccharides (HMOs) are being investigated as a novel food source with potential health benefits for infant immunity and gut health. However, limited controlled clinical trials have been conducted on a few HMOs, requiring more research to confirm the necessity of routine supplementation in formulas.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Medicine, General & Internal
Margarita Dimitroglou, Zoi Iliodromiti, Evangelos Christou, Paraskevi Volaki, Chrysa Petropoulou, Rozeta Sokou, Theodora Boutsikou, Nicoletta Iacovidou
Summary: Premature infants are more susceptible to diseases due to their immature systems, and human breast milk has been shown to be the best dietary choice for their development and protection.
Article
Biochemistry & Molecular Biology
Mitsue Sano, Veronique Ferchaud-Roucher, Bertrand Kaeffer, Guillaume Poupeau, Blandine Castellano, Dominique Darmaun
Editorial Material
Chemistry, Multidisciplinary
Stefano Fais, Lorraine O'Driscoll, Francesc E. Borras, Edit Buzas, Giovanni Camussi, Francesco Cappello, Joana Carvalho, Anabela Cordeiro da Silva, Hernando Del Portillo, Samir El Andaloussi, Tanja Ficko Trcek, Roberto Furlan, An Hendrix, Ihsan Gursel, Veronika Kralj-Iglic, Bertrand Kaeffer, Maja Kosanovic, Marilena E. Lekka, Georg Lipps, Mariantonia Logozzi, Antonio Marcilla, Marei Sammar, Alicia Llorente, Irina Nazarenko, Carla Oliveira, Gabriella Pocsfalvi, Lawrence Rajendran, Graca Raposo, Eva Rohde, Pia Siljander, Guillaume van Niel, M. Helena Vasconcelos, Maria Yanez-Mo, Marjo L. Yliperttula, Natasa Zarovni, Apolonija Bedina Zavec, Bernd Giebel
Article
Biochemistry & Molecular Biology
Paula Honorio de Melo Martimiano, Andre de Sa Braga Oliveira, Veronique Ferchaud-Roucher, Mikael Croyal, Audrey Aguesse, Isabelle Grit, Khadija Ouguerram, Sandra Lopes de Souza, Bertrand Kaeffer, Francisco Bolanos-Jimenez
JOURNAL OF NEUROCHEMISTRY
(2017)
Review
Medicine, Research & Experimental
Patricia Parnet, Vincent Paille, Francisco Bolanos Jimenez, Bertrand Kaeffer, Benoist Schaal, Sebastien G. Bouret, Valerie Amarger
M S-MEDECINE SCIENCES
(2016)
Review
Medicine, Research & Experimental
Claudine Junien, Polina Panchenko, Sara Fneich, Luciano Pirola, Sabrina Chriett, Valerie Amarger, Bertrand Kaeffer, Patricia Parnet, Jerome Torrisani, Francisco Bolanos Jimenez, Helene Jammes, Anne Gabory
M S-MEDECINE SCIENCES
(2016)
Review
Medicine, Research & Experimental
Claudine Junien, Polina Panchenko, Luciano Pirola, Valerie Amarger, Bertrand Kaeffer, Patricia Parnet, Jerome Torrisani, Francisco Bolanos Jimenez, Helene Jammes, Anne Gabory
M S-MEDECINE SCIENCES
(2016)
Article
Cell Biology
Valentin Barquissau, Benjamin Leger, Diane Beuzelin, Frederic Martins, Ez-Zoubir Amri, Didier F. Pisani, Wim H. M. Saris, Arne Astrup, Jean-Jose Maoret, Jason Iacovoni, Sebastien Dejean, Cedric Moro, Nathalie Viguerie, Dominique Langin
Article
Endocrinology & Metabolism
Didier F. Pisani, Valentin Barquissau, Jean-Claude Chambard, Diane Beuzelin, Rayane A. Ghandour, Maude Giroud, Aline Mairal, Sophie Pagnotta, Saverio Cinti, Dominique Langin, Ez-Zoubir Amri
MOLECULAR METABOLISM
(2018)
Article
Endocrinology & Metabolism
Emilie Montastier, Diane Beuzelin, Frederic Martins, Lucile Mir, Marie-Adeline Marques, Claire Thalamas, Jason Iacovoni, Dominique Langin, Nathalie Viguerie
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Article
Medicine, General & Internal
Clementine Cabridain, Helene Aubert, Bertrand Kaeffer, Virginie Badon, Marion Boivin, Vincent Dochez, Norbert Winer, Elodie Faurel-Paul, Lucie Planche, David Riochet, Annabel Maruani, Franck Perrotin, Catherine Droitcourt, Linda Lassel, Martine Tching-Sin, Natasha K. Rogers, Marie Bodinier, Sebastien Barbarot
Article
Physiology
Diane Beuzelin, Bruno Pitard, Bertrand Kaeffer
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Behavioral Sciences
Gabriel Araujo Tavares, Larissa Cavalcanti do Amaral Almeida, Julliet Araujo de Souza, Victor Vasconcelos de Farias, Felipe Leitao de Souza, Severina Cassia de Andrade Silva, Claudia Jacques Lagranha, Bertrand Kaeffer, Sandra Lopes de Souza
BEHAVIOURAL BRAIN RESEARCH
(2020)