期刊
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
卷 9, 期 1, 页码 204-214出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-018-00594-y
关键词
Centrifugal electrospinning; Dual rotation; Layers; Composite fiber; Multi-directional
资金
- National Nature Science Foundation of China [81771960]
- Fundamental Research Funds for the Central Universities [2017QNA5017]
- Key Technologies R&D Program of Zhejiang Province [2015C02035]
In this study, a dual rotation centrifugal electrospinning system (DRCES) is designed, developed, and used to prepare medicated fabrics. Through simultaneous rotation of both spinneret and collector, multi-directional blended fiber matrices (PVP and TPU) were deposited directly on the rotating collector. To detail the process, key stages of the centrifugal electrospinning process are elaborated, and the influence of gas infusion and collector rotation speed on resulting fiber morphologies was explored. Multi-directional fibrous structures show in vitro biocompatibility (fibroblast). Regulation of drug release rate was achieved using polymer composition and filament alignment. This study demonstrates a rapid fabrication method (50g/h) to engineer layered fibrous structures using DRCES, which provides a foundation for preparing complex drug matrices (single and multi-directional) for tailored active component release.
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