Article
Engineering, Chemical
Maarten Jaspers, Timo P. Roelofs, Alexandra Lohrmann, Florian Tegel, Muhammad Khalid Maqsood, Yunfei Li Song, Bernhard Meir, Richard Elkes, Bastiaan H. J. Dickhoff
Summary: The production of pharmaceutical tablets is shifting towards continuous manufacturing, which requires re-designing individual unit operations like powder blending. Continuous powder blending has been successful, but challenges arise for low-dose formulations due to difficulties in continuously dosing small amounts of powder. A semi-continuous mini-blending operation combined with batch-wise dosing can overcome these challenges. This study investigates key factors affecting blending performance in a novel, semi-continuous mini-blending process.
Article
Chemistry, Applied
Christopher J. Testa, Khrystyna Shvedova, Chuntian Hu, Wei Wu, Stephen C. Born, Bayan Takizawa, Salvatore Mascia
Summary: This study presents continuous heterogeneous crystallization processes in mixed-suspension mixed-product removal (MSMPR) crystallizers of different configurations, where APAP is crystallized directly on both porous and nonporous polymer substrates. Experimental results demonstrate that using porous polymer substrates can increase crystallization yield and reduce the risk of bulk nucleation in evaporative-cooling MSMPR crystallization systems.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Pharmacology & Pharmacy
Seth P. Forster, Erin Dippold, Abbe Haser, Daniel Emanuele, Robin Meier
Summary: The pharmaceutical industry is transitioning from traditional batch processes to continuous manufacturing. Wet granulation, however, has been challenging to incorporate into continuous processing due to limited equipment options for continuous granule drying. A new equipment combining a twin-screw wet granulator and a novel horizontal vibratory fluid-bed dryer has been developed and shown to effectively granulate and dry a range of formulations, producing granules of similar or improved quality compared to batch wet granulation and drying.
Article
Chemistry, Medicinal
Varun Sundarkumar, Zoltan K. Nagy, Gintaras V. Reklaitis
Summary: The pharmaceutical industry traditionally relies on mass manufacturing, but this approach has led to various issues. To address these challenges, novel technologies such as continuous manufacturing and 3D printing are being developed. This study aims to integrate 3D printing with crystallization to create a new processing route. Two case studies demonstrate the feasibility of this integrated system.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Environmental
Gyoung G. Jang, Joshua A. Thompson, Xin Sun, Costas Tsouris
Summary: This study investigates a novel intensified packing device for amine-CO2 scrubbing using low-aqueous solvent, which enhances heat and mass transfer efficiency to reduce the thermal energy consumption for solvent regeneration and improve CO2 capture efficiency under a wide range of operating conditions. The multifunctional intensified device facilitates contact between reactive solvent and gas phases in a single stage, while also allowing heat removal through a cooling fluid, leading to effective thermal management and significant improvement in CO2 uptake.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Arnab Chaudhuri, Wouter G. Backx, Lizette L. C. Moonen, Caesar W. C. Molenaar, Wyatt Winkenweder, Thomas Ljungdahl, John van der Schaaf
Summary: The study suggests that using a rotor-stator spinning disc reactor can enhance the productivity of tertiary amine N-oxidation reaction in a shorter period of time compared to traditional batch reactions.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Biotechnology & Applied Microbiology
Jianfa Ou, Yawen Tang, Jianlin Xu, Julian Tucci, Michael C. Borys, Anurag Khetan
Summary: This review discusses the challenges in rAAV gene therapy production, including production capability and complex manufacturing process, and proposes optimizations for upstream manufacturing processes. The advancements in rAAV production media and cell culture process development are summarized, along with the major methods for genetic element delivery to host cells and their future directions for optimization. The criteria for choosing culture vessels and the importance of process control at the production step are outlined, in addition to evaluating the advantages and limitations of the technologies.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Engineering, Chemical
Francesco Destro, Inyoung Hur, Vivian Wang, Mesfin Abdi, Xin Feng, Erin Wood, Simon Coleman, Paul Firth, Alastair Barton, Massimiliano Barolo, Zoltan K. Nagy
Summary: This paper presents a comprehensive mathematical model of an integrated filter-dryer carousel system for filtering, washing, and drying slurry streams, tracking critical quality attributes and designing isolation processes from multi-component slurries.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Chemistry, Applied
Maolin Sun, Jingxin Yang, Youtian Fu, Chaoming Liang, Hong Li, Guoming Yan, Chao Yin, Wei Yu, Yueyue Ma, Ruihua Cheng, Jinxing Ye
Summary: The continuous flow process for preparing betahistine with a 90% isolated yield is efficient and environmentally friendly, using 2-vinylpyridine and saturated methylamine hydrochloride as starting materials. The process offers a 50% reduction in process mass intensity compared to batch processes, making it energy-efficient and cost-effective.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Biotechnology & Applied Microbiology
Joao P. Mendes, Barbara Fernandes, Earl Pineda, Shashi Kudugunti, Mike Bransby, Rene Gantier, Cristina Peixoto, Paula M. Alves, Antonio Roldao, Ricardo J. S. Silva
Summary: This study compares alternating tangential flow (ATF) and Tangential Flow Depth filtration (TFDF) techniques for the production and continuous harvest of AAV8. The results show that medium exchange strategy improves AAV expression and TFDF enables high recovery yields during harvest.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Peter Sagmeister, Dainis Kaldre, Joerg Sedelmeier, Christian Moessner, Kurt Puntener, Dominique Kummli, Jason D. Williams, C. Oliver Kappe
Summary: Continuous flow processing is an effective method for the formation of 1,5-tetrazoles, achieving high yields with high concentration and short residence time. Two orthogonal PAT methods, NMR and FTIR, were utilized for real-time quantification of starting materials and products, facilitating successful technology transfer and process optimization.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Review
Biochemical Research Methods
Dongming Xie
Summary: This review discusses the major challenges and strategies for continuous biomanufacturing, including minimizing contamination risk, enhancing genetic stability, decoupling cell growth from product formation, using modeling approach to accelerate research and development, and new strategies for intelligent and next-generation manufacturing.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Claas Steenweg, Astrid Ina Seifert, Nils Boettger, Kerstin Wohlgemuth
Summary: The CVSF concept offers unique features such as modularity and rapid start-up behavior for continuous particle isolation from suspensions. By incorporating washing modules and a vacuum-induced (pre-) drying setup, it can produce dried and free-flowing product particles efficiently.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Engineering, Industrial
Zhaoxiang Chen, Zhen Chen, Di Zhou, Tangbin Xia, Ershun Pan
Summary: This paper proposes a novel opportunistic maintenance optimization model for continuous process manufacturing systems (CPMS) by introducing the concept of opportunity time window (OTW) to constrain maintenance opportunities within production constraints. By considering different types of maintenance actions and stochastic epistemic uncertainty, a simulated annealing-based adaptive immune algorithm (SAAIA) is developed to optimize the system's production efficiency and performance.
JOURNAL OF MANUFACTURING SYSTEMS
(2023)
Article
Engineering, Chemical
Lingqing Yan, Thomas F. Edgar, Michael Baldea
Summary: This article discusses using dynamic process intensification (DPI) as a strategy to improve energy efficiency in distillation processes, demonstrating through a case study on a hydrocarbon mixture that DPI can significantly reduce reboiler energy consumption compared to steady-state operation.
Review
Biotechnology & Applied Microbiology
Xiaoping Guan, Jinhao Bai, Jingchang Zhang, Ning Yang
Summary: This paper presents an overview of multiphase flow characteristics and modeling methods in polymer electrolyte membrane water electrolysis (PEMWE), emphasizing the significance of regulating the microstructure of the transport layer and distinguishing the effects of multiphase flow in the flow channel from those in the transport layer.
CURRENT OPINION IN CHEMICAL ENGINEERING
(2024)
Article
Biotechnology & Applied Microbiology
Natasha J. Chrisandina, Shivam Vedant, Eleftherios Iakovou, Efstratios N. Pistikopoulos, Mahmoud M. El-Halwagi
Summary: This paper provides a brief review of recent progress in conceptual frameworks and quantitative metrics for analyzing and designing resilience-aware process systems, as well as discussing key research opportunities in the field of process system resilience, specifically the challenges in integrating resilience throughout the life cycle and across the spatiotemporal scales.
CURRENT OPINION IN CHEMICAL ENGINEERING
(2024)
Article
Biotechnology & Applied Microbiology
Ya-Nan Yang, Jie Jin, Li-Tao Zhu, Yin-Ning Zhou, Zheng-Hong Luo
Summary: This article reviews the application of thermal runaway criteria, with emphasis on the significance of the divergence criterion. The general application procedures of the divergence criterion are illustrated through examples in process safety assessment, process parameter optimization, and process monitoring and control.
CURRENT OPINION IN CHEMICAL ENGINEERING
(2024)
Article
Biotechnology & Applied Microbiology
Edirisooriya Mudiyanselage Nimanthi Thiloka Edirisooriya, Huiyao Wang, Sankha Banerjee, Karl Longley, William Wright, Walter Mizuno, Pei Xu
Summary: This study evaluates the economic feasibility of using alternative water sources for agriculture and identifies strategies to address the challenges. In the Southwest United States, the reuse of filtered disinfected municipal wastewater is the most cost-effective option. Using alternative water for irrigation faces challenges such as high costs, energy demand, concentrate disposal, and soil salinity management. Economic feasibility can be improved by implementing renewable energy-powered decentralized desalination systems.
CURRENT OPINION IN CHEMICAL ENGINEERING
(2024)
Article
Biotechnology & Applied Microbiology
Manoj Kolel-Veetil
Summary: Recent advances in nonthermal plasma technology have led to remarkable progress in the remediation of PFAS, occurring at the water-bubble/air interface and increasingly in the bubble interiors, with simultaneous presence of multiple oxidative and reductive species.
CURRENT OPINION IN CHEMICAL ENGINEERING
(2024)