期刊
ADVANCED SCIENCE
卷 6, 期 2, 页码 -出版社
WILEY
DOI: 10.1002/advs.201801479
关键词
acrolein; breast cancer; breast-conserving surgery; imaging; TAMRA phenyl azide
资金
- JSPS KAKENHI [JP16H03287, JP16K13104, JP15H05843, JP18K07265]
- Russian Government Program for Competitive Growth
- Center of Innovation Program from Japan Science and Technology Agency, JST
Clean operating margins in breast cancer surgery are important for preventing recurrence. However, the current methods for determining margins such as intraoperative frozen section analysis or imprint cytology are not satisfactory since they are time-consuming and cause a burden on the patient and on hospitals with a limited accuracy. A click-to-sense probe is developed based on the detection of acrolein, which is a substance released by oxidatively stressed cancer cells and can be visualized under fluorescence microscopy. Using live breast tissues resected from breast cancer patients, it is demonstrated that this method can quickly, selectively, and sensitively differentiate cancer lesion from normal breast gland or benign proliferative lesions. Since acrolein is accumulated in all types of cancers, this method could be used to quickly assess the surgical margins in other types of cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据