期刊
ADVANCED SCIENCE
卷 6, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/advs.201801138
关键词
cancer; ciliopathy; obesity; receptor tyrosine kinases; ubiquitin-mediated protein degradation
资金
- Japan Society for the Promotion of Science KAKENHI [16K08547, 17K08269, 18K06890, 15H02398]
- Takeda Science Foundation
- Naito Foundation
- Grants-in-Aid for Scientific Research [17K08269, 18K06890, 15H02398, 16K08547] Funding Source: KAKEN
Primary cilia detect extracellular cues and transduce these signals into cells to regulate proliferation, migration, and differentiation. Here, the function of primary cilia as signaling hubs of growth factors and morphogens is in focus. First, the molecular mechanisms regulating the assembly and disassembly of primary cilia are described. Then, the role of primary cilia in mediating growth factor and morphogen signaling to maintain human health and the potential mechanisms by which defects in these pathways contribute to human diseases, such as ciliopathy, obesity, and cancer are described. Furthermore, a novel signaling pathway by which certain growth factors stimulate cell proliferation through suppression of ciliogenesis is also described, suggesting novel therapeutic targets in cancer.
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