Multistage Delivery Nanoparticle Facilitates Efficient CRISPR/dCas9 Activation and Tumor Growth Suppression In Vivo

Thermo-triggered Release of CRISPR-Cas9 System by Lipid-Encapsulated Gold Nanoparticles for Tumor Therapy

(2018) Peng Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conditional replication of oncolytic viruses based on detection of oncogenic mRNA

(2018) M Renteln   GENE THERAPY

Smart Peptide-Based Supramolecular Photodynamic Metallo-Nanodrugs Designed by Multicomponent Coordination Self-Assembly

(2018) Shukun Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

(2017) Julia Joung et al.   Nature Protocols

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

(2017) Kunwoo Lee et al.   Nature Biomedical Engineering

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

(2016) Jason B. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

(2016) Ming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment

(2015) Jinqiang Wang et al.   ACS Nano

The challenges facing block copolymer micelles for cancer therapy: In vivo barriers and clinical translation

(2015) Sina Eetezadi et al.   ADVANCED DRUG DELIVERY REVIEWS

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

(2015) Isaac B Hilton et al.   NATURE BIOTECHNOLOGY

Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

(2015) Jean-Charles Nault et al.   NATURE GENETICS

Nanoparticles for Imaging, Sensing, and Therapeutic Intervention

(2014) Lara K. Bogart et al.   ACS Nano

The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation

(2014) Annie M. Tremblay et al.   CANCER CELL

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Differential regulation of TGF-β–induced, ALK-5–mediated VEGF release by SMAD2/3 versus SMAD1/5/8 signaling in glioblastoma

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Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy

(2013) Jin-Zhi Du et al.   BIOTECHNOLOGY ADVANCES

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors

(2013) Stephanie Deshayes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

(2013) David Bikard et al.   NUCLEIC ACIDS RESEARCH

Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery

(2012) Erlei Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The holistic 3M modality of drug delivery nanosystems for cancer therapy

(2012) Jin Sun et al.   Nanoscale

Hallmarks of Cancer: The Next Generation

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Assessment of Tumor Metastasis by the Direct Determination of Cell-Membrane Sialic Acid Expression

(2010) Akira Matsumoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance

(2010) K. C. Schreck et al.   CLINICAL CANCER RESEARCH

Charge‐Conversion Ternary Polyplex with Endosome Disruption Moiety: A Technique for Efficient and Safe Gene Delivery

(2008) Yan Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonviral Vectors for Gene Delivery

(2008) Meredith A. Mintzer et al.   CHEMICAL REVIEWS

The effect of particle design on cellular internalization pathways

(2008) S. E. A. Gratton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA