期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 4, 期 11, 页码 3848-3853出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b01097
关键词
microneedles; vascular anastomosis; tubular construct; cytocompatibility; heparin coating
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [NRF-2016M3A9E9941743, 2017M3A9E9087117]
To make up for the shortcomings of the suture-based approach and current coupler devices including long suturing time, exhaustive training, additional mechanical setting, and narrow working windows for size and type of diverse vessel types, a new, suture-free microneedle coupler was developed in this study. The needle shape for improved anastomosis performance and the condition for antithrombotic surface immobilization were determined. In particular, the polymer materials help to maintain healthy phenotypes of main vascular cell types. The performance in rabbit and porcine models of end-to-end vascular anastomosis indicate that this device can serve as a potent alternative to the current approaches.
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