Article
Chemistry, Multidisciplinary
Mengmeng Hou, Yuanxin Zhong, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: Recent studies have demonstrated that by growing PDA on the surface of CoS, SH-PEG and chemotherapeutic agent DOX can be loaded onto CoS@PDA NSs to form CoPPD NSs with excellent photothermal properties and high DOX loading capacity. These NSs can accelerate drug release under acidic TME conditions and exhibit a significant chemotherapeutic-enhanced photothermal therapeutic effect on solid tumors.
CHINESE CHEMICAL LETTERS
(2021)
Review
Chemistry, Multidisciplinary
Chunling Wang, Junchao Xu, Yinlong Zhang, Guangjun Nie
Summary: Abnormal angiogenesis is a significant characteristic of malignant tumors, and nanomedicine provides a precise approach to regulate tumor blood vessels. Nanomedicines have the advantage of reducing systemic toxicity and enhancing therapeutic efficacy, as well as enabling more precise drug delivery and release through specific structural designs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Hui Xiong, Xiaoyan Liu, Zuohan Xie, Linyuan Zhu, Haipeng Lu, Cheng Wang, Jing Yao
Summary: By combining nanodrugs targeting the tumor microenvironment, this study enhances the efficacy of tumor vascular normalization treatment by inhibiting glycolysis in tumor cells and endothelial cells, leading to better antitumor effects.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Charlotte Ebeling Barbier, Femke Heindryckx, Hans Lennernaes
Summary: Clinical data review highlights the limitations of transarterial chemoembolization (TACE) as a treatment for hepatocellular carcinoma (HCC) and the complex interactions between drug delivery, tumor targeting mechanisms, liver pathophysiology, patient and tumor heterogeneity, and resistance mechanisms. Understanding and addressing these factors are essential to improving the effectiveness of TACE and developing novel drug delivery systems for locoregional treatment of HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Ziwan Xu, Wenyao Zhen, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R. Weichselbaum, Wenbin Lin
Summary: In this study, a novel nanoscale metal-organic framework (nMOF) Hf-TP-SN, containing an X-ray-triggerable 7-ethyl-10-hydroxycamptothecin (SN38) prodrug, was designed for synergistic radiotherapy and chemotherapy. Upon X-ray irradiation, Hf-12 secondary building units served as radiosensitizers to enhance the generation of hydroxyl radicals, leading to the on-demand release of SN38. The Hf-TP-SN showed 5-fold higher release of SN38 compared to its molecular counterpart, resulting in significant cytotoxicity to cancer cells and efficient tumor growth inhibition in colon and breast cancer mouse models.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Zhilin Liu, Yu Zhang, Na Shen, Jiali Sun, Zhaohui Tang, Xuesi Chen
Summary: Nanomedicine improves the efficiency of delivering antitumor drugs into tumors, but insufficient tumor penetration hampers therapeutic efficacy. Vascular disrupting agent (VDA) nanomedicines selectively destroy immature tumor vessels, block the supply of oxygen and nutrients, and increase vascular permeability, reducing the dependence on enhanced permeability and retention effect. This review discusses the recent progress and application of VDA nanomedicines in cancer therapy, including mechanisms, delivery strategies, and combination therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Materials Science, Biomaterials
Mei Jiang, Yuchen Lin, Xiaocui Fang, Mingpeng Liu, Lilusi Ma, Jingyi Liu, Mengting Chen, Yanlian Yang, Chen Wang
Summary: A novel delivery system for cisplatin was constructed using gold nanoclusters and PEGylated cationic peptide, which showed improved cellular uptake and enhanced chemotherapeutic efficiency against cisplatin-resistant lung cancer cells. In vivo assays confirmed the profound anti-tumor efficiency of the system, attributed to deep penetration and accumulation of the nanoscale cisplatin@GC-pKs via the enhanced permeability and retention (EPR) effect in tumor tissues, suggesting a potential treatment strategy for various cisplatin-resistant malignancies.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Oncology
Yujin Lee, Peter Graham, Yong Li
Summary: Breast cancer lacks effective management approaches for metastasis and therapy-resistant disease. Extracellular vesicles (EVs) play an important role in intercellular communication and are associated with pathological conditions. Cancer cells secrete EVs and communicate with neighboring cells in the tumor microenvironment, which contributes to BC metastasis, immune escape, and chemo-resistance. EVs have emerged as potential therapeutic targets and carriers for BC treatment, stimulating angiogenesis, inhibiting the immune response, and promoting cancer metastasis.
Article
Pharmacology & Pharmacy
Yan Ting Liu, Shreya Goel, Megumi Kai, Jose Alberto Moran Guerrero, Thao Nguyen, Junhua Mai, Haifa Shen, Arturas Ziemys, Kenji Yokoi
Summary: Our study showed that tumors derived from different seed and soil sources exhibited varying responses to immunotherapy, with differences in PD-L1 expression, therapeutic delivery, immune cell accumulation, and tumor coagulation. This highlights the importance of understanding organ-specific heterogeneity in the delivery and response to immunotherapy in polyclonal tumors.
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Review
Nanoscience & Nanotechnology
Anseo Choi, Kaila Javius-Jones, Seungpyo Hong, Hansoo Park
Summary: Nanoparticle-based drug delivery systems have limitations in tumor targeting and therapeutic outcomes. Cell-based drug delivery systems, using blood cells, immune cells, and stem cells with natural tumor tropism and low immunogenicity, provide a solution to these problems. In this review, we discuss the benefits and drawbacks of cell-based therapies, as well as their mechanisms in tumor microenvironments. Additionally, we summarize different strategies for loading therapeutic agents onto or inside circulating cells, and their current applications in disease treatments.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Seung Mo Jin, Sang Nam Lee, Jung Eun Kim, Yeon Jeong Yoo, Chanyoung Song, Hong Sik Shin, Hathaichanok Phuengkham, Chang Hoon Lee, Soong Ho Um, Yong Taik Lim
Summary: A novel immune modulating suspension containing inducers of cell death and supra-adjuvants can effectively increase cytotoxic T lymphocytes and alleviate immune suppression in the tumor microenvironment, leading to enhanced T cell infiltration and inhibition of tumor metastasis. This approach shows promise in increasing the response rate of immune checkpoint blockade therapy, presenting a new nanotheranostic strategy in cancer immunotherapy.
Article
Biotechnology & Applied Microbiology
Lorna Westwood, Elaine Emmerson, Anthony Callanan
Summary: Increased cancer rates necessitate effective treatments for radiation-induced tissue damage. This study demonstrates that incorporating retinyl acetate into electrospun fibers can mitigate the damaged microenvironment caused by radiotherapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Jieying Zhang, Fang Li, Lili Su, Qian Hu, Jianfeng Li, Xingjun Zhu
Summary: Tumor vascular disruption has become a promising strategy for cancer therapy in recent decades. Nanocomposites loaded with therapeutic materials and drugs are expected to improve the accuracy of anti-vascular therapy and minimize side effects. However, how to prolong blood circulation of therapeutic nanocomposites for enhanced accumulation in tumor vasculature and how to monitor the initial efficacy of anti-vascular therapy for early evaluation of prognosis remain unsolved.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Beining Yang, Fanze Meng, Jihao Zhang, Kerun Chen, Siyu Meng, Kaiyong Cai, Yanli Zhao, Liangliang Dai
Summary: The tumor microenvironment (TME) plays a crucial role in tumor occurrence, development, and metastasis. Reprogramming TME is a potential therapeutic target for effective tumor damage. Nanobiomaterials have been extensively integrated into the construction of engineered drug delivery nanosystems for TME normalization therapy.
Article
Nanoscience & Nanotechnology
Charlene M. Dawidczyk, Luisa M. Russell, Margot Hultz, Peter C. Searson
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2017)
Article
Nanoscience & Nanotechnology
Hyun-June Jang, Taein Lee, Jian Song, Luisa Russell, Hui Li, Jennifer Dailey, Peter C. Searson, Howard E. Katz
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Chemistry, Multidisciplinary
Luisa M. Russell, Margot Hultz, Peter C. Searson
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Chemistry, Multidisciplinary
Jian Song, Jennifer Dailey, Hui Li, Hyun-June Jang, Luisa Russell, Pengfei Zhang, Peter C. Searson, Jeff Tza-Huei Wang, Allen D. Everett, Howard E. Katz
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Neurosciences
Moriah E. Katt, Lakyn N. Mayo, Shannon E. Ellis, Vasiliki Mahairaki, Jeffrey D. Rothstein, Linzhao Cheng, Peter C. Searson
FLUIDS AND BARRIERS OF THE CNS
(2019)
Article
Biotechnology & Applied Microbiology
Moriah E. Katt, Eric V. Shusta
CURRENT OPINION IN CHEMICAL ENGINEERING
(2020)
Article
Endocrinology & Metabolism
Benjamin D. Gastfriend, Koji L. Foreman, Moriah E. Katt, Sean P. Palecek, Eric Shusta
Summary: This study utilized multiple independent human brain single-cell RNA sequencing datasets to construct a transcriptomic database of human brain mural cells, with key findings validated by RNA fluorescence in situ hybridization. The research contributes to improving knowledge about the molecular constituents of human brain mural cells, serves as a resource for generating hypotheses about their function, and will facilitate comparative evaluation of animal and in vitro models.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Jason M. Lajoie, Moriah E. Katt, Elizabeth A. Waters, Brantley R. Herrin, Eric Shusta
Summary: This study describes an innovative screening platform for identifying new BBB targeting molecules, using a class of lamprey antigen recognition proteins called variable lymphocyte receptors (VLRs). By immunizing lamprey with murine brain microvessel plasma membranes and cloning the resultant repertoire into the yeast surface display system, 16 VLR clones were identified that target in vivo-relevant BBB membrane proteins. Three lead VLR candidates, VLR-Fc-11, VLR-Fc-30, and VLR-Fc-46, selectively target the brain vasculature and traffic within brain microvascular endothelial cells after intravenous administration in mice.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
David Pamies, Daphne Wiersma, Moriah E. Katt, Liang Zhao, Johannes Burtscher, Georgina Harris, Lena Smirnova, Peter C. Searson, Thomas Hartung, Helena T. Hogberg
Summary: Oxidative stress is closely related to brain aging and neurodegenerative diseases, especially in Parkinson's disease. This study used a human brain 3D model (BrainSpheres) to investigate the effects of different oxidative stress-inducing compounds on dopaminergic neurons, and found that these compounds caused molecular deficits and neuronal loss.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Pharmacology & Pharmacy
Julia Georgieva, Moriah Katt, Zhou Ye, Benjamin J. Umlauf, Cody J. Wenthur, Eric Shusta
Summary: The restrictive nature of the brain vasculature limits the exposure of central nervous system (CNS) to blood-borne biotherapeutics. The use of receptor-mediated transcytosis (RMT) mechanisms in blood-brain barrier endothelial cells can increase the bioavailability of such therapeutics. The antibody 46.1 has been identified to accumulate in the mouse brain and can deliver drug cargo to the CNS, primarily through the cavernous sinus-arterial route.
Review
Oncology
Moriah E. Katt, Andrew D. Wong, Peter C. Searson
Article
Neurosciences
Moriah E. Katt, Raleigh M. Linville, Lakyn N. Mayo, Zinnia S. Xu, Peter C. Searson
FLUIDS AND BARRIERS OF THE CNS
(2018)
Review
Pharmacology & Pharmacy
A. Komin, L. M. Russell, K. A. Hristova, P. C. Searson
ADVANCED DRUG DELIVERY REVIEWS
(2017)