Article
Engineering, Biomedical
Elena Alvarez, Manuel Estevez, Carla Jimenez-Jimenez, Montserrat Colilla, Isabel Izquierdo-Barba, Blanca Gonzalez, Maria Vallet-Regi
Summary: A simple and versatile methodology is proposed for designing biocompatible and multicomponent MSNs based nanosystems for infection management, which show a notable improvement in antibiofilm effect as well as osteogenic capability. The nanosystems contain two antimicrobial agents, levofloxacin and Zn2+, and demonstrate high antimicrobial efficacy and positive effects on osteoblastic differentiation and cell viability.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Biomaterials
Sepanta Hosseinpour, Yuxue Cao, Jingyu Liu, Chun Xu, Laurence J. Walsh
Summary: The study demonstrates that lyophilized mesoporous silica nanoparticles can efficiently deliver miRNA to promote osteogenic differentiation of bone marrow mesenchymal cells, and remain functional after long-term storage.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Analytical
Berrin Kucukturkmen, Wali Inam, Fadak Howaili, Mariam Gouda, Neeraj Prabhakar, Hongbo Zhang, Jessica M. Rosenholm
Summary: Microfluidics has been used to coat mesoporous silica nanoparticles (MSNs) with polymeric layers for achieving high protein loading and retention. This study demonstrates the potential of microfluidic technologies in the design of protein delivery systems, allowing for multicomponent systems and preservation of protein stability.
Article
Chemistry, Physical
Wei Wang, Fengmin Zhong, Dun Wang, Yuqi Zhao, Dongdong Peng, Shuang Li, Qian Ning, Shengsong Tang, Cui-Yun Yu, Hua Wei
Summary: The construction of dual gatekeepers-functionalized mesoporous organic silica nanoparticles with both physical and chemical mechanisms provides a solution for the extracellular stability and intracellular therapeutic efficiency. This study demonstrates the successful use of diselenium-bridged MONs decorated with a dual gatekeeper, azobenzene/polydopamine, for modulated drug delivery properties.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Chemistry, Multidisciplinary
Haesoo Lee, Miseop Choi, Ha-Eun Kim, Minki Jin, Woo-Jin Jeon, Minwoo Jung, Hyelim Yoo, Jong-Hee Won, Young-Guk Na, Jae-Young Lee, Hasoo Seong, Hong-Ki Lee, Cheong-Weon Cho
Summary: In this study, doxorubicin-loaded mesopomus silica nanoparticles (MSNs) coated with mannose grafted poly (acrylic acid) copolymer (DOX@MSNs-man-g-PAA) were developed to enhance the hemocompatibility and target efficacy to cancer cells. The DOX@MSNs-man-g-PAA showed sustained and pH-dependent drug release with improved hemocompatibility and enhanced uptake in breast cancer cells through mannose receptor-mediated endocytosis, leading to increased intracellular ROS and changes in mitochondrial membrane potential. This formulation exhibited superior tumor-suppressing activity in mice inoculated with MDA-MB-231 cells.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Kokila Thirupathi, Madhappan Santhamoorthy, Sivaprakasam Radhakrishnan, Selvakumari Ulagesan, Taek-Jeong Nam, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: A mesoporous silica-based drug delivery system was synthesized by conjugating a PNIPAm-PAAm copolymer onto the mesoporous silica surface. The copolymer acts as a gatekeeper that responds to temperature and pH changes, allowing controlled drug delivery. The system exhibited good biocompatibility and was readily taken up by MDA-MB-231 cells, making it suitable for drug delivery applications where sustained drug release at higher temperatures is required.
Article
Materials Science, Biomaterials
Nahida Rasool, Deepa Negi, Yashveer Singh
Summary: Osteoporosis is a chronic bone disorder characterized by decreased bone mass and increased fracture risk. This study developed thiolated, bioactive mesoporous silica nanoparticles (MSN-SH) with antioxidant and regenerative properties for potential treatment of osteoporosis. MSN-SH exhibited high antioxidant activity, protected cells from reactive oxygen species-induced damage, and induced osteogenesis. It also inhibited osteoclastogenesis, promoted migration of osteoblast cells, and showed potential as a complementary treatment for osteoporosis. The surface modification of MSN-SH offers a simple and economical method to enhance its properties and introduce new activities.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Environmental
Kaijun Gou, Yumei Wang, Linlin Xie, Xianmou Guo, Yingyu Guo, Jia Ke, Lulu Wu, Sanming Li, Heran Li
Summary: Chiral mesoporous silica nanoparticles (CMSNs) have unique physicochemical properties and advantages in biological behavior, making them valuable in various applications such as chiral catalysis, chiral selectivity, chiral recognition, separation, drug delivery, and medical research. Studies on CMSNs have made significant progress in synthesis, chirality origination mechanisms, structural properties, and practical applications, indicating great potential in the field of pharmaceutical science and beyond.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Pichaporn Sutthavas, Zeinab Tahmasebi Birgani, Pamela Habibovic, Sabine van Rijt
Summary: Mesoporous silica nanoparticles (MSNs) can effectively promote bone regeneration by surface coating multiple ions, inducing osteogenic gene expression under basic cell culture conditions. Using MSNs as delivery vehicles requires comparatively lower ion doses to achieve similar osteogenic effects compared to direct ion administration in the medium.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Min-Hsuan Tsou, Cheng-Chang Lee, Zhi-Yuan Wu, Zui-Harng Lee, Hsiu-Mei Lin
Summary: In this study, fucoidan was extracted from brown algae using a hot water extraction method, and synthesized into drug carrier-nanoparticles for drug delivery. Experimental results showed that rMSN-EuGd@Fucoidan exhibited higher cytotoxicity against A549 cancer cells compared to fucoidan itself.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Yufeng Zhai, Zhi Qiao, Runze Yu, Zhu Fang, Gang Chen, Zhiyuan Zhu
Summary: The dynamic formation process of SBA-15 using hexane as a swelling agent is investigated through in situ SAXS technique. The micelles transform rapidly from spherical to cylindrical shapes and self-assemble into a hexagonal structure. The growth of SBA-15 involves two distinct processes related to the formation of micelles and superlattices. The methodology developed here holds promise for widespread applications in the in situ X-ray scattering observation of various chemical reaction processes, paving the way for the design and synthesis of complex functional materials.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Engineering, Biomedical
Marcia T. Tavares, Vitor M. Gaspar, Maria Monteiro, Jose Paulo S. Farinha, Carlos Baleizao, Joao F. Mano
Summary: Utilizing a multi-bioactive nanocomposite bioink combining organic GelMA and inorganic MSNCaPDex nanoparticles, this study successfully fabricated 3D bioprintable constructs for potential applications in bone tissue repair and regeneration. The constructs demonstrated attractive bioactivity properties and the ability to induce osteogenic differentiation in stem cells without additional biochemical or mechanical stimuli.
Article
Chemistry, Physical
Montserrat Colilla, Maria Vallet-Regi
Summary: Bacterial antimicrobial resistance is a major threat to global health, and the stalled antibiotic research pipeline has worsened the situation. Nanotechnology offers a potential solution by using nanocarriers to transport and deliver antimicrobials to overcome bacterial resistant barriers. Mesoporous silica nanoparticles (MSNs) have attracted attention due to their unique features. This perspective article outlines recent research in the design and development of organically modified MSNs to fight bacterial infections, addressing the current challenges and future perspectives.
CHEMISTRY OF MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Qian Rui, Jun Gao, Zheng-Zhi Yin, Junyao Li, Wenrong Cai, Datong Wu, Yong Kong
Summary: A simple and smart drug controlled delivery system was developed by using biodegradable mesoporous silica nanoparticles (BMSN) for the loading of an anti-cancer drug methotrexate (MTX). The MTX loaded BMSN (BMSN-MTX) was encapsulated in the hydrogels of carboxymethyl chitosan (CMCS)/oxidized pullulan (OPL) generated through Schiff base reaction. The release of MTX from the BMSN-MTX-gel can be triggered by both pH and glutathione (GSH), making it an efficient drug delivery system.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Engineering, Biomedical
Hui Huang, Zeyu Wang, Liang Chen, Hong Yu, Yu Chen
Summary: Catalytic therapy has shown promise in enhancing therapeutic efficacy and reducing side effects by converting less toxic or nontoxic endogenous substances into highly toxic reactive species to induce cell death. This review summarizes the recent advances in the development and use of catalytic biomaterials and nanomedicines in various biomedical applications. The study focuses on the use of endogenous activators and exogenous stimuli to improve treatment efficacy, and discusses the biosafety and biocompatibility of these materials. The challenges and future opportunities for catalytic biomaterials and nanomedicines are also highlighted.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Materials Science, Biomaterials
Dongmiao Cao, Liang Chen, Ziwen Zhang, Yu Luo, Linjing Zhao, Chunping Yuan, Jie Lu, Xijian Liu, Jingchao Li
Summary: This article summarizes the application of degradable nanomaterials in cancer imaging and treatment. It presents four mechanisms of tumor microenvironment-responsive degradation and briefly summarizes external stimulation degradation. The applications of nanomaterials in bioimaging are outlined, and typical examples of biodegradable nanomaterials in various cancer therapies are focused.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Jie Cui, Xiao Yu, Yihong Shen, Binbin Sun, Wanxin Guo, Mingyue Liu, Yujie Chen, Li Wang, Xingping Zhou, Muhammad Shafiq, Xiumei Mo
Summary: Tissue engineering has gained widespread attention as a method of producing patient-specific tissue constructs for tissue repair. Different types of scaffold materials have been developed, and the choice of materials should consider their mechanical properties, biodegradability, biocompatibility, and bioresorbability. Inorganic materials, with their broad range of physico-chemical properties, can be used as scaffold fillers and offer a good alternative for tissue engineering. This review focuses on the use of inorganic components in electrospun membranes and emphasizes the biological advantages of incorporating inorganic materials in tissue repair.
Article
Chemistry, Multidisciplinary
Shanshan Zhang, Shujun Xia, Liang Chen, Yu Chen, Jianqiao Zhou
Summary: In this study, COF nanobowls were synthesized and utilized as activatable nanosensitizers with tumor-specific sonodynamic activity. The high crystallinity of the COF nanobowls enables efficient loading of the sonosensitizer and the in situ growth of manganese oxide inhibits non-specific damage to normal tissues. When reacting with tumor-overexpressed glutathione, the gatekeeper manganese oxide is decomposed to restore the ROS generation capability, leading to increased intracellular ROS stress and enhanced sonodynamic efficacy.
Article
Chemistry, Multidisciplinary
Yuyi Liu, Liang Chen, Zhiyang Chen, Minchao Liu, Xilei Li, Yufang Kou, MengMeng Hou, Huiren Wang, Xiaomin Li, Bo Tian, Jian Dong
Summary: In this study, a Janus nanoplatform (Janus-CPS) was developed for the simultaneous early diagnosis and effective treatment of rheumatoid arthritis (RA). The Janus nanostructure with increased reactive oxygen species scavenging capability and the loading of micheliolide in the mesopores showed promising results in vitro cellular experiments and in vivo collagen-induced arthritis (CIA) model. Additionally, the Janus-CPS exhibited desirable effectiveness in detecting early-stage RA lesions using near-infrared imaging.
Article
Chemistry, Multidisciplinary
Xiaojun Zhou, Yuhan Qian, Liang Chen, Tao Li, Xin Sun, Xiaojun Ma, Jinwu Wang, Chuanglong He
Summary: The study demonstrates the construction of a dual-factor delivery scaffold, which combines short nanofibers and a 3D printed scaffold, for guiding vascularized bone regeneration. The scaffold exhibits an adjustable porous structure and strong compressive strength. The sequential release of the loaded factors promotes angiogenesis and osteogenesis, accelerating tissue ingrowth and vascularized bone regeneration. This study provides a promising strategy for constructing a bone microenvironment-matched biomimetic scaffold for bone regeneration.
Article
Chemistry, Multidisciplinary
Xinyue Cao, Ying Wang, Xinran Song, Wanqing Lou, Xiaoyan Li, Weiping Lu, Kai Chen, Liang Chen, Yu Chen, Bingcang Huang
Summary: Sonodynamic therapy has the potential to revolutionize biomedicine with its non-invasiveness, deep tissue penetration, and controllability. However, the lack of suitable nanosonosensitizers with reactive oxygen species generation ability is a significant obstacle for its wider application. This study designs a bismuth-based nanosonosensitizer (Bi-HJ) that combines tumor therapy with metabolic regulation, photothermal therapy, and computed tomography imaging. The results demonstrate the effectiveness of Bi-HJ in achieving enhanced tumor therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yanqiu Duan, Yang Yu, Peilai Liu, Yao Gao, Xinyue Dai, Liang Zhang, Liang Chen, Yu Chen
Summary: The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. In this study, a COF-based sonosensitizer (TPE-NN) is synthesized using reticular chemistry-based synthesis from two inert monomers. The sonodynamic activity of TPE-NN is enhanced by embedding copper (Cu)-coordinated sites, and ultrasound (US) irradiation augments the chemodynamic efficacy of TPE-NN-Cu. This study demonstrates the potential of COF-based sonosensitizers for nanodynamic therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Lingqing Zong, Yang Yu, Junhao Wang, Peilai Liu, Wei Feng, Xinyue Dai, Liang Chen, Cindy Gunawan, Sung Lai Jimmy Yun, Rose Amal, Soshan Cheong, Zi Gu, Yu Chen
Summary: In this study, researchers propose a strategy to develop an oxygen-vacancy-rich MoOx nanonetwork on fluorine-free Mo2C MXene, which can generate reactive oxygen species under ultrasound irradiation and effectively kill bacteria without damaging normal tissues.
Article
Engineering, Biomedical
Wei Yang, Jianwei Cao, Hui Cheng, Liang Chen, Meihua Yu, Yu Chen, Xingang Cui
Summary: The approved use of two mRNA vaccines (BNT162b2 and mRNA-1273) worldwide in late 2020 has demonstrated the success of mRNA therapeutics and lipid nanoformulation technology in protecting against coronaviruses during the COVID-19 pandemic. This innovative approach with nanoformulations and mRNA therapeutics is believed to hold promise in targeted cancer immunotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Microbiology
Shana Chen, Quan Fu, Mandlaa Mandlaa, Qingchun Wang, De Sheng, Saijilahu Saijilahu, Tana Tana, Dezhi Yang
Summary: Brucellosis is rapidly spreading in Inner Mongolia, China, and investigating its genetics may provide insights into bacterial host adaptation mechanisms. This study reports the genome sequence of Brucella melitensis strain BM6144 isolated from a human patient.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Chemistry, Multidisciplinary
Ziyi Lu, Shan Du, Jiaxun Li, Min Zhang, Huali Nie, Xiaojun Zhou, Fulun Li, Xinwei Wei, Jinqiang Wang, Fuyao Liu, Chuanglong He, Guang Yang, Zhen Gu
Summary: A simple method using the Langmuir-Blodgett (LB) technique is developed to deposit antibacterial nanoparticles of various shapes, sizes, and compositions onto microneedles (MNs), which solves the concern of skin infections caused by MNs during long-term transdermal drug delivery. This technique offers advantages over conventional dip coating techniques, providing controlled coating layers, uniform and high coverage, and a straightforward fabrication process. The antibacterial MNs demonstrate superior bacterial elimination in vitro and in vivo without compromising payload capacity, drug release, or mechanical strength. It is believed that this functional nanoparticle coating technique expands the capabilities of MNs in long-term transdermal drug delivery.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhiyang Chen, Liang Chen, Yiqun Ma, Yuyi Liu, Qianyi Zhang, Hao Qin, Yu Chen, Bo Tian, Jian Dong
Summary: A nanosystem is designed and fabricated for synergistic sonodynamic-immunometabolic therapy of spinal-metastasized tumors by integrating oxygen-deficient molybdenum oxide (ODM) nanosonosensitizers and R7 peptides. The nanosystem combines sonodynamic therapy with tumor metabolic regulation, achieving concurrent immune activation and immunosuppressive tumor microenvironment remodeling.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ziyi Lu, Shan Du, Jiaxun Li, Min Zhang, Huali Nie, Xiaojun Zhou, Fulun Li, Xinwei Wei, Jinqiang Wang, Fuyao Liu, Chuanglong He, Guang Yang, Zhen Gu
Summary: The Langmuir-Blodgett technique is used to deposit antibacterial nanoparticles onto microneedles, providing a fast-acting and long-lasting antibacterial effect without sacrificing their payload capacity, drug release, or mechanical strength.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Ai Yang, Yue Wang, Qian Feng, Kanwal Fatima, Qianqian Zhang, Xiaojun Zhou, Chuanglong He
Summary: This study fabricated a multifunctional scaffold based on a hard-and-soft integration strategy, which can simultaneously promote osteogenesis and allow for non-invasive monitoring of in vivo bone regeneration. The scaffold significantly enhances bone formation through controlled release of simvastatin (SV) and enables visualization of scaffold degradation using alkaline phosphatase-responsive near-infrared II fluorescence imaging and magnetic resonance imaging.
ADVANCED HEALTHCARE MATERIALS
(2023)
