Article
Engineering, Environmental
Xuedong Shu, Jun Shu, Yao Wang, Huan Deng, Junwei Zhang, Jing He, Fang Wu
Summary: This study successfully addresses the challenges of chronic wound repair and excessive scarring by developing a novel multifunctional ROS-scavenging hydrogel, CT-X. This hydrogel effectively removes ROS, promotes wound healing, and reduces scar formation in normal and diabetic wounds.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Yuanmeng He, Kaiyue Liu, Shen Guo, Rong Chang, Chen Zhang, Fangxia Guan, Minghao Yao
Summary: A multifunctional hydrogel (OGF) based on oxidized dextran, gallic acid-grafted gelatin, and Ferric ion showed excellent antibacterial ability and promoted the healing of infected wounds in diabetic patients.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Karine R. Begnini, Luiza C. Pereira, Juliano L. Faccioni, Guido Lenz, Eduardo C. Filippi-Chiela
Summary: Tracking individual cells has provided new insights into cellular behavior in human health and disease, adding a dynamic component to the already complex heterogeneity of single cells. This review discusses the technical aspects and biological findings in analyzing the behavior of individual cells, with a focus on clinically relevant human conditions such as embryo development, stem cells biology, inflammation, cancer, and microbiology. The review also emphasizes the key technical considerations for planning and performing experiments involving the analysis of individual cells over long periods.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Pengdong Xie, Yangyang Yang, Di Gong, Lirong Yu, Ye Han, Yuanyuan Zong, Yongcai Li, Dov Prusky, Yang Bi
Summary: This study found that chitooligosaccharide (COS) can enhance the resistance of potato tubers during wound healing by regulating reactive oxygen species metabolism. COS maintains cell membrane integrity by eliminating excessive H2O2 and improving antioxidant capacity.
Article
Biotechnology & Applied Microbiology
Huiyang Li, Xiaoyu Liang, Youlu Chen, Kaijing Liu, Xue Fu, Chuangnian Zhang, Xiaoli Wang, Jing Yang
Summary: In this study, a wound dressing composed of konjac glucomannan and gallic acid was developed, which could accelerate wound healing by promoting macrophage polarization and reducing reactive oxygen species levels. In vivo experiments showed that it had excellent anti-inflammatory properties.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Xin Shi, Tong Zhou, Shenyu Huang, Yuejun Yao, Peifang Xu, Shaodan Hu, Chenxi Tu, Wei Yin, Changyou Gao, Juan Ye
Summary: Ocular alkali burn is a serious emergency characterized by persistent inflammation and irreversible vision loss. A double network biomaterial, composed of electrospun nanofibres of thioketal-containing polyurethane (PUTK) and a ROS-scavenging hydrogel (RH), was prepared and transplanted onto a rat corneal alkali burn model. The composite patch showed strong antioxidant activity and accelerated corneal wound healing by inhibiting inflammation, promoting epithelial regeneration, and decreasing scar formation.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yaru Guo, Shuai Ding, Changshuai Shang, Chenguang Zhang, Menggang Li, Qinghua Zhang, Lin Gu, Boon Chin Heng, Shihan Zhang, Feng Mei, Ying Huang, Xuehui Zhang, Mingming Xu, Jiuhui Jiang, Shaojun Guo, Xuliang Deng, Lili Chen
Summary: A new class of multifunctional PtCuTe nanosheets with strong ROS scavenging and ROS-independent antibacterial properties is reported. It promotes endothelial tip cell formation, enhances vascular tube formation, stimulates macrophage polarization toward M2 phenotype, and improves fibroblast mobility, remarkably superior to the traditional PtCu nanoenzyme. Consequently, PtCuTe application accelerates diabetic wound healing at a rate not reported before.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Junjun Li, Rong Du, Qiong Bian, Danping Zhang, Siqian Gao, Anran Yuan, Xiaoying Ying, Youqing Shen, Jianqing Gao
Summary: In this study, a novel HA material modified with ATEMPO was synthesized to promote angiogenesis and prevent excessive ROS production, leading to alleviation of oxidative stress response and enhancement of chronic wound healing. Through experiments in rat models, it was found that HA-g-TEMPO significantly improved wound closure efficacy and potentially reduced scar formation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Jiafei Zhu, Qiutong Jin, He Zhao, Wenjun Zhu, Zhuang Liu, Qian Chen
Summary: The development of novel ROS-scavenging sutures coated with GANPs significantly improves wound healing by promoting wound closure, reducing inflammation reaction, and decreasing scar formation.
Article
Engineering, Biomedical
Jixi Huang, Shuai Wang, Xiaoping Wang, Jing Zhu, Zhenqiang Wang, Ximu Zhang, Kaiyong Cai, Jixi Zhang
Summary: The development of nanoadhesives has successfully addressed the shortcomings of previous adhesive systems in wound healing efficiency. This is achieved by synergistically combining functional components to enhance interparticle cohesion, boost reactive oxygen species scavenging activity, and promote angiogenesis. This system holds great potential for the treatment of skin wounds.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Haiqi Zhang, Hongtao Hu, Yangyang Dai, Liaobing Xin, Qian Pang, Songying Zhang, Lie Ma
Summary: Chronic diabetic wounds with persistent inflammatory responses pose a serious threat to human health. Designing a multifunctional wound dressing for treatment and monitoring of the wound remains a challenge. In this study, an ionic conductive hydrogel with intrinsic reactive oxygen species (ROS)-scavenging properties and good electroactivity was developed for achieving the synergistic treatment and monitoring of diabetic wounds.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Saba Qureshi, Sonam Chandra, Deepti Chopra, Divya Dubey, Veena Jain, Somendu Kumar Roy, Ratan Singh Ray
Summary: This study showed that nabumetone can induce phototoxicity and photogenotoxicity, leading to cell damage and death. Additionally, it was found to cause UV-induced genotoxicity. Therefore, patients using this drug should avoid sunlight exposure, and healthcare providers should provide proper guidance on drug photosensitivity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Fei Gong, Nailin Yang, Jiachen Xu, Xiaoyuan Yang, Kailu Wei, Linqian Hou, Bo Liu, He Zhao, Zhuang Liu, Liang Cheng
Summary: This study developed calcium hydride (CaH2)-based dressings with anti-oxidation and anti-inflammation properties for accelerated wound healing. By releasing hydrogen molecules (H-2) and scavenging excess reactive oxygen species (ROS), the CaH2 dressings were able to reduce inflammation levels, promote tissue regeneration and angiogenesis, offering a potential therapeutic option for inflammatory diseases.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Hao Cheng, Zhe Shi, Kan Yue, Xusheng Huang, Yichuan Xu, Chenghao Gao, Zhongqi Yao, Yu Shrike Zhang, Jian Wang
Summary: The study introduces a novel sprayable hydrogel wound dressing loaded with cerium oxide nanoparticles and an antimicrobial peptide, providing ROS-scavenging and antibacterial properties. By adopting a mussel-inspired strategy, the hydrogel exhibited improved binding affinity to wet skin surfaces and demonstrated excellent biocompatibility.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Guangxin Duan, Ling Wen, Xingwei Sun, Zhuxin Wei, Ruixue Duan, Jiangfeng Zeng, Jiabin Cui, Chunyi Liu, Zepeng Yu, Xiaofang Xie, Mingyuan Gao
Summary: A study introduced molybdenum-based nanodots (MoO3-X) for diabetic ulcers treatment, which possess ROS scavenging ability and antibacterial properties, effectively reducing inflammation, promoting cell regeneration and angiogenesis, accelerating ulcer healing, and reducing drug-resistant bacterial infections.
Article
Engineering, Biomedical
Basil Mathai, Santanu Dhara, Sanjay Gupta
Summary: This study focuses on developing a novel computational framework for predicting bone remodelling around an uncemented femoral implant using multiscale topology optimization and a parameterized cellular model. The research demonstrates that the topology optimization model shows higher correlation with the SED model, and the bone density distributions are comparable to clinical observations. However, more robust modeling of boundary conditions is needed for 3D models.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Madhurima Das, Preetam Guha Ray, Santanu Dhara, Somenath Roy
Summary: This study demonstrates the potential of newly synthesized graphite/cobalt sulfide/PANI-based ternary composites in removing Congo red dye from industrial wastewater. The composites showed high efficiency in removing CR dye in a short period of time and were found to be non-toxic.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Nanoscience & Nanotechnology
Arpita Roy, Kalipada Manna, Preetam Guha Ray, Santanu Dhara, Sagar Pal
Summary: A multiple-stimuli-responsive hydrogel with high stretchability and transparency has been synthesized in this study. It can be used to fabricate a flexible pressure sensor and a drug release carrier.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biophysics
Rahul Gautam Talukdar, Ceby Mullakkara Saviour, Kaustubh Tiwarekar, Santanu Dhara, Sanjay Gupta
Summary: This study investigated the effects of interbody cages on load transfer and bone remodeling using three-dimensional models. The study found that variations in cage porosity affected peri-prosthetic stress distributions and bone remodeling around the cages. Compared to solid cages, porous cages decreased stresses and strains in the cancellous bone, but increased the range of motion. The increase in bone density predicted in the solid cages may influence disk degeneration in the adjacent segment. An interbody cage with 65-78% porosity could be a viable alternative, provided sufficient mechanical strength is offered.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Materials Science, Ceramics
Venkata Sundeep Seesala, Santanu Dhara
Summary: A novel strategy of green net shaping ceramic dough was proposed to fabricate a customizable ceramic dental implant with biomimetic porosity. Experimental results showed that the implant had excellent integrity and suitable porosity for bone ingrowth.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Lakshmi M. Mukundan, Hema Bora, Ragavi Rajasekaran, Santanu Chattopadhyay, Santanu Chattopadhyay
Summary: This study presents the synthesis of antibiotic nanohybrid with a sheddable PCL shell grafted over GS-charged BG nanospheres via surface-initiated polymerization. The influence of monomer/initiator feed ratio on the synthesized PCL was evident, while the percentage grafting and shell thickness remained comparable regardless of the quantity of drug-loaded particles used. The successful grafting of PCL was confirmed by different characterization techniques. The effective shedding of the shell in the aqueous environment and the subsequent release of GS were confirmed. The controlled burst release of drug and its antibacterial activity were also demonstrated.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Abir Dutta, Kaushik Mukherjee, Venkata Sundeep Seesala, Kaushik Dutta, Ranjan Rashmi Paul, Santanu Dhara, Sanjay Gupta
Summary: This study investigated the influence of plate-screw type combination on load transfer in mandibular reconstruction using patient specific customized Ti plates. Two designs of solid and holed plates were considered, along with bicortical and monocortical screw fixation. The results showed that the combination of plate and screw types affects the stress state in the reconstructed mandible. Based on the findings, either solid Ti plate with bicortical screws or Ti plate with holes along with monocortical screws can be used for partial mandibulectomy after tumor resection, with all components demonstrating safe performance under the mastication cycle. However, the choice of combination depends on the condition and severity of the mandibular tumor.
MEDICAL ENGINEERING & PHYSICS
(2023)
Correction
Materials Science, Biomaterials
Lakshmi M. Mukundan, S. Remya Nirmal, Nikhil Kumar, Santanu Dhara, Santanu Chattopadhyay
Summary: In this study, engineered nanostructures were incorporated into sol-gel bioactive glass, leading to enhanced bioactivity and modulated drug delivery. The findings are significant for the development of bioactive materials and exploration of drug delivery systems.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Biotechnology & Applied Microbiology
Sayantanee Mukherjee, Rajib Dhar, Swathi Jonnalagadda, Sukhamoy Gorai, Sagnik Nag, Rishav Kar, Nobendu Mukerjee, Dattatreya Mukherjee, Rishabh Vatsa, Devi Arikketh, Anand Krishnan, Rohit Gundamaraju, Saurabh Kumar Jha, Athanasios Alexiou, Marios Papadakis
Summary: Breast cancer is a challenging global health crisis, and the discovery of extracellular vesicles (EVs), specifically exosomes, has made significant advancements in cancer research. Tumour cell-derived exosomes have a great impact on cancer development and progression, regulating various events such as tumor microenvironment remodeling, immune cell suppression, angiogenesis, metastasis, and therapeutic resistance. Exosome-based screening and treatment provide promising approaches for breast cancer detection and therapy, and exosome research enables closer precision oncology. This review aims to motivate researchers to explore exosomes and develop efficient and affordable theranostics for breast cancer.
Review
Engineering, Biomedical
Krishna Dixit, Hema Bora, Jhansi Lakshmi Parimi, Gayatri Mukherjee, Santanu Dhara
Summary: Chronic wounds are the result of an imbalanced inflammatory response in the immune microenvironment. Tissue engineered grafts have been effective in wound healing, but encounter challenges in scar remodeling, immune rejection, and vascularization. These limitations are linked to the immune cells involved in healing. Immunomodulatory biomaterials bridge this gap by delivering modulating factors to key inflammatory cells in the wound microenvironment. The physico-chemical properties of biomaterials play a substantial role in the interaction between cells and materials, affecting cytokine gradients and surface marker expression.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Food Science & Technology
Pawan Prabhakar, Sayan Mukherjee, Ankit Kumar, Suraj Kumar, Deepak Kumar Verma, Santanu Dhara, Mrinal Kumar Maiti, Mamoni Banerjee
Summary: The present research aims to establish the scientific basis for the use of bioactive phytochemicals in Carica papaya as functional food and drug compound for managing diabetes. Molecular docking and pharmacokinetic analysis revealed the potential of these phytochemicals to inhibit α-amylase and α-glucosidase enzymes responsible for high blood glucose levels. The study also optimized the extraction process of bioactive components from C. papaya leaves and identified several major phytochemicals with anti-diabetic activity. The findings demonstrate the potential of using these compounds to develop anti-diabetic food compositions and medications.
Article
Multidisciplinary Sciences
Pravin Vasudeo Vaidya, Abir Dutta, Suparna Rooj, Rahul Talukdar, Komal Bhombe, Venkata Sundeep Seesala, Zahiruddin Quazi Syed, Tapas Kumar Bandyopadhyay, Santanu Dhara
Summary: Implant stability is crucial for faster patient recovery. Superior bone-implant contact influenced by the surgical tool and proper irrigation with water can minimize heat generation and improve osseointegration. Optimizing tool geometry is key to minimizing shear force, heat generation, and necrosis during final osteotomy site preparation.
Article
Biotechnology & Applied Microbiology
Sumanta Mukherjee, Santanu Dhara, Partha Saha
Summary: This article presents a method for designing a graded porous structured acetabular implant and identifies suitable parameters for manufacturing the model through additive manufacturing. The method is based on slice-wise modification and binary image processing. The designed model exhibits closely conforming porosities and pore sizes to the target values.
BIOENGINEERING-BASEL
(2023)
Review
Materials Science, Biomaterials
Asmita Biswas, Ragavi Rajasekaran, Baisakhee Saha, Krishna Dixit, Pravin Vasudeo Vaidya, Atul Kumar Ojha, Santanu Dhara
Summary: The human placenta and umbilical cord, natural birth biowaste, are a rich source of bioactive macromolecules, growth factors, collagen and GAGs, as well as high-quality stem cells. Placenta-derived MSCs have been widely used in research and medical applications due to their sustainable sourcing, high viability, and multipotent lineage. With appropriate utilization and management, they have the potential to address the global MSC shortage in stem cell therapy and biomedical waste disposal. Current research and applications include ECM-based nanofiber fabrication, disease models, micro-tissue, hybrid models, and artificial implants. Utilizing birthing biomedical waste in medical engineering and research can provide a sustainable source of stem cells and extracellular matrix for enhanced biocompatibility and regeneration.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Samiran Morang, Jay Hind Rajput, Anwesha Mukherjee, Atharva Poundarik, Bodhisatwa Das, Niranjan Karak
Summary: This study introduces a new strategy to enhance the self-healing ability and mechanical properties of polyurethane (PU) films. By utilizing the triple synergistic effect of a dynamic hard domain, multiple hierarchical hydrogen bonding, and semi-interpenetrating network formation, a series of self-healable waterborne PU/polyacrylic films were prepared. These films exhibit excellent mechanical robustness and biodegradability. The study also demonstrates the potential of these films in biomedical applications.
MATERIALS ADVANCES
(2023)
