Article
Cell Biology
Jianye Zhong, Abai Xu, Peng Xu, Minhong Su, Peng Wang, Zhe Liu, Boping Li, Chunxiao Liu, Ning Jiang
Summary: In this study, a novel circRNA, hsa_circ_0000235 (circ235), was discovered and its role in the glycolytic process and progression of bladder cancer (Bca) was investigated. The findings showed that circ235 was significantly increased in Bca tissues, and its upregulation was associated with a worse prognosis. In vitro and in vivo experiments demonstrated that circ235 promoted glycolysis, tumor growth, and metastasis by sponging miR-330-5p and activating monocarboxylate transporter 4 (MCT4).
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Xin Lin, Lu Han, Chuncai Gu, Yihong Lai, Qiuhua Lai, Qingyuan Li, Chengcheng He, Yan Meng, Lei Pan, Side Liu, Aimin Li
Summary: MiR-452-5p is up-regulated in CRC tissues, promoting cell proliferation, cycle transition, and chemoresistance while inhibiting apoptosis. It targets PKN2 and DUSP6, activating the ERK/MAPK signaling pathway, and is transcriptionally regulated by c-Jun. MiR-452-5p may serve as a potential therapeutic target and clinical response biomarker for CRC.
Article
Oncology
Feng Liu, Wen Li, Zhihui Jin, Jia Ye
Summary: The study found that METTL3-regulated circRNF220 can promote the progression of osteosarcoma by modulating the miR-330-5p/survivin axis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yuxiao Chang, Ziran Huang, Fengyi Hou, Yuejiao Liu, Likun Wang, Zhen Wang, Yifan Sun, Zhiyuan Pan, Yafang Tan, Lei Ding, Hong Gao, Ruifu Yang, Yujing Bi
Summary: This study revealed an important relationship between Parvimonas micra (P. micra) and colorectal cancer (CRC) through cell experiments and mouse models. Transcriptomics and microRNA sequencing showed that P. micra promoted CRC development through the activation of the miR-218-5p/Ras/ERK/c-Fos pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Hongxv Wang, Danyu Du, Jianwen Huang, Shuai Wang, Xv He, Shengtao Yuan, Jing Xiao
Summary: This study reveals the role of GPR27 in hepatocellular carcinoma (HCC) progression. The results demonstrate that downregulation of GPR27 inhibits cell proliferation and colony formation, while overexpression of GPR27 has the opposite effect. Furthermore, GPR27 expression affects the activation of the MAPK/ERK signaling pathway in HCC cells, thereby modulating cell proliferation.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Immunology
Chengyan Tang, Yu Chen, Hongjiao Jin, Li Lei, Yunfeng Xiang, Yu Cheng, Bo Huang
Summary: The role of miR-342-5p in EV71 replication was explored in this study. The overexpression of miR-342-5p promoted EV71 replication and inhibited the innate immune response to antiviral disease. This suggests that miR-342-5p enhances EV71 replication through the Wnt/CTNNB1 signaling pathway.
MICROBIAL PATHOGENESIS
(2023)
Article
Oncology
Ying Qi, Jingni He, Ying Zhang, Lidong Wang, Yifan Yu, Baiyu Yao, Zhong Tian
Summary: The study revealed that upregulated circular RNA hsa_circ_0001666 in papillary thyroid carcinoma (PTC) is associated with lymph node metastasis and promotes cancer aggressiveness. Knocking down hsa_circ_0001666 inhibits cell proliferation and induces apoptosis in PTC. Furthermore, hsa_circ_0001666 promotes PTC tumorigenesis through the miR-330-5p/miR-193a-5p/miR-326/ETV4 pathway, suggesting its potential as a therapeutic target for PTC.
Article
Cell Biology
Shuai Zhang, Yuan Lu, Hong-Yu Jiang, Zhi-Mei Cheng, Zi-Jing Wei, Yun-Hao Wei, Ting Liu, Bai-Juan Xia, Xu-Ya Zhao, Yu Huang, Xun Zou, Rong Liu, Shi Zhou
Summary: CircC16orf62 acts as an oncogene in HCC progression, promoting cancer development through the miR-138-5p/PTK2/Akt pathway. It functions as a molecular sponge for miR-138-5p and a competitive endogenous RNA for PTK2, activating the AKT/mTOR pathway.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Cheng Gao, Renfei Zhu, Jianbo Shen, Tianxin Xu, Yongjun She, Zhong Chen
Summary: This study investigates the impact of RBM12 in the progression of LC, revealing the exact molecular mechanism through which RBM12 promotes the initiation and progression of LC, providing some reference for the clinical management of LC.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Tae Won Kim, Haein Ji, Nak Hyeon Yun, Chang Hoon Shin, Hyeon Ho Kim, Yong Beom Cho
Summary: This study identified AFAP1-AS1 and MLK7-AS1 as ceRNAs that promote the progression of colorectal cancer by reducing the levels of tumor-suppressing miRNAs miR-149-5p and miR-485-5p.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Oncology
Da Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Bing Wang, Yongjun Chen
Summary: The study found that in cholangiocarcinoma, miR-155-5p targets the 3' UTR of SOX1, activating the RAF/MEK/ERK pathway and promoting cancer progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yafu Zhou, Jianhua Yan, Huiguo Chen, Wenwu Zhou, Guohua Xiao, Haoyu Zou, Jinsong Yang
Summary: This study identified the regulatory role of miR-4652-5p and RND1 in lung squamous cell carcinoma. miR-4652-5p promoted the proliferation, migration, and invasion of LUSC cells by downregulating RND1 expression, and may also affect cell adhesion.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Dezhi Li, Tao Zhou, Yaqin Li, Yanwei Xu, Xianyi Cheng, Junhui Chen, Wei V. Zheng
Summary: LINC02362 is identified as a potential tumor-inhibitory lncRNA that could serve as a biomarker for the prognosis of HCC and a promising therapeutic agent for patients with HCC.
Article
Oncology
Dan Yin, Zhi-Qiang Hu, Chu-Bin Luo, Xiao-Yi Wang, Hao-Yang Xin, Rong-Qi Sun, Peng-Cheng Wang, Jia Li, Jia Fan, Zheng-Jun Zhou, Jian Zhou, Shao-Lai Zhou
Summary: In hepatocellular carcinoma (HCC), genomic copy numbers of LINC01133 are increased and positively correlated with its expression. Higher copy number of LINC01133 predicts a poor prognosis in HCC patients. LINC01133 promotes HCC progression by sponging miR-199a-5p and interacting with ANXA2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Zheng He, Meng Tian, Xuan Fu
Summary: miR-30c-5p downregulation in hepatocellular carcinoma is significantly associated with patient survival and tumor size, affecting cell proliferation and migration, with RAB32 identified as a crucial target. These findings highlight the important role of miR-30c-5p in HCC growth and invasion through the miR-30c-5p-RAB32 axis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)