Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses

(2017) Douglas P. Dyer et al.   Scientific Reports

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Colin W. Steele et al.   CANCER CELL

Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer

(2016) Keisuke Yamamoto et al.   Oncotarget

Sharpin promotes hepatocellular carcinoma progression via transactivation of Versican expression

(2016) Y Tanaka et al.   Oncogenesis

Activation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61

(2016) Makoto Sano et al.   NEOPLASIA

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

(2013) Geou-Yarh Liou et al.   JOURNAL OF CELL BIOLOGY

Lipopolysaccharide-Induced M2 to M1 Macrophage Transformation for IL-12p70 Production Is Blocked by Candida albicans Mediated Up-Regulation of EBI3 Expression

(2013) Xing-Feng Zheng et al.   PLoS One

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

(2011) Hideaki Ijichi et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis

(2010) Zhihong Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity

(2010) Je-In Youn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXC-chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer

(2009) Yoichi Matsuo et al.   INTERNATIONAL JOURNAL OF CANCER

K-Ras Promotes Angiogenesis Mediated by Immortalized Human Pancreatic Epithelial Cells through Mitogen-Activated Protein Kinase Signaling Pathways

(2009) Y. Matsuo et al.   MOLECULAR CANCER RESEARCH

The role of CXC chemokines and their receptors in cancer

(2008) Jo Vandercappellen et al.   CANCER LETTERS

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE