期刊
NANOMATERIALS
卷 8, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/nano8100824
关键词
copper oxide nanoparticle; cytotoxicity; reactive oxygen species; Nrf2; Drosophila melanogaster
类别
资金
- Chulalongkorn University
- Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University
- Ratchadapiseksompote Endowment Fund, Chulalongkorn University
Copper oxide nanoparticles (CuONPs) have attracted considerable attention, because of their biocide potential and capability for optical imaging, however CuONPs were shown to be highly toxic in various experimental model systems. In this study, mechanism underlying CuONP-induced toxicity was investigated using Drosophila as an in vivo model. Upon oral route of administration, CuONPs accumulated in the body, and caused a dose-dependent decrease in egg-to-adult survivorship and a delay in development. In particular, transmission electron microscopy analysis revealed CuONPs were detected inside the intestinal epithelial cells and lumen. A drastic increase in apoptosis and reactive oxygen species was also observed in the gut exposed to CuONPs. Importantly, we found that inhibition of the transcription factor Nrf2 further enhances the toxicity caused by CuONPs. These observations suggest that CuONPs disrupt the gut homeostasis and that oxidative stress serves as one of the primary causes of CuONP-induced toxicity in Drosophila.
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