Article
Infectious Diseases
Lu Gao, Xiangdong Sun, Honglin Yang, Quangang Xu, Juan Li, Jingli Kang, Ping Liu, Yi Zhang, Youming Wang, Baoxu Huang
Summary: The study conducted a preliminary analysis of African swine fever outbreaks in China, finding significantly higher outbreak rates in small farms compared to medium and large farms. Swill feeding and mechanical dissemination were identified as major contributing factors. The response speed has been gradually increasing. Recommendations include improving biosecurity levels and enhancing supervision in breeding, transportation, and slaughter practices.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Review
Virology
Yuanjia Liu, Xinheng Zhang, Wenbao Qi, Yaozhi Yang, Zexin Liu, Tongqing An, Xiuhong Wu, Jianxin Chen
Summary: This paper summarizes the three key elements related to the transmission of African swine fever virus (ASFV) and the relevant prevention and control strategies, including vaccines, drugs, ASFV-resistant pigs, disinfection, and biosecurity. It also discusses the critical technical points concerning pig farm repopulation, which is essential to the pork industry.
Article
Agricultural Economics & Policy
Meilin Ma, H. Holly Wang, Yizhou Hua, Fei Qin, Jing Yang
Summary: The study suggests that current subsidy policies in China for the hog industry may not be the most efficient way to reduce pork prices. Instead, shifting some subsidies to the chicken farming industry could potentially lower pork prices faster and at a lower cost, benefiting consumers, producers, and the government.
Article
Agriculture, Dairy & Animal Science
Evelina Stonciute, Katja Schulz, Alvydas Malakauskas, Franz J. Conraths, Marius Masiulis, Carola Sauter-Louis
Summary: Hunters' willingness and motivation play a crucial role in the effectiveness of control measures for African swine fever in wild boar. Understanding their attitudes and beliefs towards these measures is essential for successful implementation. The study in Lithuania revealed that hunters reject certain measures like hunting restrictions and selective female hunting, while highlighting the importance of improving relationships with stakeholders for better acceptance of control measures.
Article
Immunology
Naijun Han, Hailong Qu, Tiangang Xu, Yongxin Hu, Yongqiang Zhang, Shengqiang Ge
Summary: African swine fever (ASF) is a highly lethal and contagious disease in China, and there is still no credible commercially available vaccine. China has made significant progress in the research and development of ASF vaccines, but further clinical application requires more tests and research accumulation.
Correction
Food Science & Technology
Daniel Mason-D'Croz, Jessica R. Bogard, Mario Herrero, Sherman Robinson, Timothy B. Sulser, Keith Wiebe, Dirk Willenbockel, H. Charles J. Godfray
Summary: A correction to the paper has been published.
Article
Mathematics, Applied
Haitao Song, Jian Li, Zhen Jin
Summary: African swine fever (ASF) is a disease caused by the African swine fever virus (ASFV) and has resulted in significant economic losses in China. By using a nonlinear dynamic model, the effect of culling on the transmission of ASFV was investigated, and it was found that culling can greatly contain the spread of the virus.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2023)
Article
Veterinary Sciences
Satoshi Ito, Jaime Bosch, Marta Martinez-Aviles, Jose Manuel Sanchez-Vizcaino
Summary: The study highlights the distribution of lower virulent African swine fever virus in China and the potential risk of the virus spreading from China to other regions of the world.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Ana Catarina Urbano, Fernando Ferreira
Summary: African swine fever (ASF) is a lethal and highly contagious viral disease that poses a serious threat to the global swine industry. Although progress has been made in vaccine development, there are still challenges to overcome, such as cross-protection, safety, and the lack of suitable animal models.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Virology
Malgorzata Juszkiewicz, Marek Walczak, Grzegorz Wozniakowski, Katarzyna Podgorska, Raymond Rowland
Summary: African swine fever is a contagious disease that poses a major threat to the global pig industry and agricultural economies. Despite the lack of an effective vaccine, the disease has been spreading in Europe and Asia, causing significant economic losses. Biosecurity measures and disinfection play crucial roles in prevention and control.
Review
Immunology
Zilong Qiu, Zhaoyao Li, Quanhui Yan, Yuwan Li, Wenjie Xiong, Keke Wu, Xiaowen Li, Shuangqi Fan, Mingqiu Zhao, Hongxing Ding, Jinding Chen
Summary: African swine fever, caused by the African swine fever virus, is a highly contagious global disease that spread rapidly since its introduction to Georgia in 2007. With no vaccine currently available, prevention and control rely on early detection and strict biosecurity measures.
Review
Biology
Zhaoyao Li, Wenxian Chen, Zilong Qiu, Yuwan Li, Jindai Fan, Keke Wu, Xiaowen Li, Mingqiu Zhao, Hongxing Ding, Shuangqi Fan, Jinding Chen
Summary: African swine fever is a highly fatal viral disease in domestic pigs and wild boars, impacting pig-raising countries and pork trade. Safe and effective vaccines are urgently needed to control outbreaks. Understanding the structure, function, immune response, and diagnosis of the ASF virus is crucial for vaccine development.
Article
Mathematics
Xin Pei, Mingtao Li, Jianghong Hu, Juan Zhang, Zhen Jin
Summary: The study focuses on the spatiotemporal transmission features of African swine fever in Mainland China. It identifies hotspots and clusters of the disease, as well as the direction and speed of its global and local transmission. The study also calculates the isolation and exposure of infected sites to reveal the infection risk in different susceptible areas and time periods.
Article
Agriculture, Dairy & Animal Science
Huan Wang, Meijun Chen, Ziyao Guo, Yangyang Shen, Yufan Chen, Ting Luo, Yuying Liu, Jianqiang Li, Fang Wang, Jiangjun Wan
Summary: African swine fever has had a significant impact on China's pig industry, causing fluctuations in live pig supply and prices, resulting in substantial economic losses for farmers. This study analyzed survey data to examine the current situation and factors influencing farmers' epidemic prevention and control behaviors. The findings indicate that the overall biosecurity level on pig farms is low. Factors such as technical training, farm size, income share, production organization, and government inspection significantly influence farmers' adoption of biosecurity measures. The study emphasizes the importance of biosecurity in enhancing farm resilience to major animal diseases and provides insights for policymakers.
Article
Immunology
Siqi Cai, Zezhong Zheng, JiaoJiao Cheng, Lintao Zhong, Ran Shao, Feiyan Zheng, Zhiying Lai, Jiajun Ou, Liang Xu, Pei Zhou, Gang Lu, Guihong Zhang
Summary: This study identified swine interferon-induced transmembrane proteins (SwIFITMs) as having potent antiviral activity against African swine fever virus (ASFV). These proteins were found to be constitutively expressed in most porcine tissues and their expression levels were induced by ASFV infection or swine interferon treatment. Overexpression of SwIFITMs inhibited ASFV replication in Vero cells, while knockdown of these genes enhanced ASFV replication in PAMs. The study also demonstrated that endogenous IFITMs play a role in restricting ASFV replication. Overall, this research expands our understanding of the antiviral activity of porcine IFITMs against ASFV.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peng Zhang, Yuping Yin, Tao Wang, Wei Li, Chengguo Li, Xiangyu Zeng, Wenchang Yang, Ruizhi Zhang, Yu Tang, Liang Shi, Ruidong Li, Kaixiong Tao
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Microbiology
Yanjiao Lu, Zhenli Huang, Meijia Wang, Kun Tang, Shanshan Wang, Pengfei Gao, Jungang Xie, Tao Wang, Jianping Zhao
Summary: Lymphopenia, elevated level of d-dimer, hs-CTnI and hs-CRP were independent predictors of mortality in young adults with severe COVID-19, and young adults with two or more abnormalities above were more prone to death. Similar predictive effects of these factors were also observed in all-age patients with severe COVID-19.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Health Care Sciences & Services
Qingquan Liu, Yiru Wang, Xuecheng Zhao, Lixuan Wang, Feng Liu, Tao Wang, Dawei Ye, Yongman Lv
Summary: This study found that BCR can serve as a useful prognostic factor for COVID-19 patients, with BCR above the normal range being associated with increased risk of mortality. Developing an individualized prediction nomogram based on BCR can effectively predict the risk of mortality and assist clinicians in making early individualized treatment decisions.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Infectious Diseases
Tao Wang, Liang Wang, Yu Han, Li Pan, Jing Yang, Maowen Sun, Pingping Zhou, Yuan Sun, Yuhai Bi, Hua-Ji Qiu
Summary: The study revealed that African swine fever virus undergoes genomic variations during adaptation to different cell lines, with deletions in MGF300 and MGF360 genes playing a crucial role in early adaptation to HEK293T cells. However, after adaptation, the virus displayed reduced infectivity in primary porcine alveolar macrophages compared to the wild-type strain. Further research is needed to understand the biological functions of the deletions and mutations associated with ASFV infection in different cells and animals.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Microbiology
Li Pan, Rui Luo, Tao Wang, Mengnan Qi, Bing Wang, Maowen Sun, Yuzi Luo, Chen Ji, Yuan Sun, Hua-Ji Qiu
Summary: This study demonstrated that highly complexed iodine (HPCI) disinfectant could rapidly and efficiently inactivate African swine fever virus (ASFV), representing an effective disinfectant for ASF control.
VETERINARY MICROBIOLOGY
(2021)
Editorial Material
Infectious Diseases
Tao Wang, Rui Luo, Yuan Sun, Hua-Ji Qiu
Summary: The major risks of ASF spread are insufficient biosecurity measures and human behaviors. Therefore, a safe and effective vaccine seems to be a reasonable demand for the prevention and control of ASF. Several critical issues need to be addressed to commercialize an ideal ASF LAV, including a stable cell line for manufacturing vaccines, differentiation of infected from vaccinated animals (DIVA), and cross-protection from different genotypes.
INFECTIOUS DISEASES OF POVERTY
(2021)
Correction
Virology
Pingping Zhou, Lian-Feng Li, Kehui Zhang, Bing Wang, Lijie Tang, Miao Li, Tao Wang, Yuan Sun, Su Li, Hua-Ji Qiu
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Maowen Sun, Shaoxiong Yu, Hailiang Ge, Tao Wang, Yongfeng Li, Pingping Zhou, Li Pan, Yu Han, Yuying Yang, Yuan Sun, Su Li, Lian-Feng Li, Hua-Ji Qiu
Summary: African swine fever (ASF) is a lethal viral disease of pigs caused by African swine fever virus (ASFV). A recent study found that deleting the A137R gene in ASFV attenuates its virulence and promotes the expression of type I interferon (IFN) in primary porcine alveolar macrophages. The A137R protein negatively regulates the cGAS-STING-mediated IFN-beta signaling pathway through the autophagy-mediated lysosomal degradation of TBK1. This study enhances the understanding of ASFV immunoevasion strategies and provides new insights for the development of live attenuated ASF vaccines.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Yingying Lei, Yu Xiong, Dagang Tao, Tao Wang, Tianlun Chen, Xufei Du, Gang Cao, Jiagang Tu, Jinxia Dai
Summary: In this study, a reverse genetic system for the culture of recombinant red-spotted grouper nervous necrosis virus (RGNNV) is developed for the first time. Attenuated RGNNV strains with the loss of B2 protein expression were constructed and compared in terms of growth rate, Mx1 expression, and virulence. This study provides a potential tool for further research on viral protein function, virulence pathogenesis, and vaccine development of RGNNV.
Article
Virology
Pingping Zhou, Jingwen Dai, Kehui Zhang, Tao Wang, Lian-Feng Li, Yuzi Luo, Yuan Sun, Hua-Ji Qiu, Su Li
Summary: The study reveals an antagonistic mechanism by which ASFV-AH240R suppresses the host immune response by manipulating activation of the NF-kappa B signaling and NLRP3 inflammasome.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Rui Luo, Tao Wang, Maowen Sun, Li Pan, Shujian Huang, Yun Sun, Hua-Ji Qiu
Summary: This study demonstrated that the ASFV-P121 strain, which has a deletion in the left variable region (LVR), lost the ability to replicate in primary porcine alveolar macrophages (PAMs). However, a mutant virus with the same LVR deletion only showed a 10-fold reduction in growth compared to the wild-type virus. Importantly, this large deletion did not affect virus factory formation or virion morphogenesis. These findings provide insights into the molecular mechanism of ASFV cell tropism change.
Article
Microbiology
Tao Wang, Rui Luo, Jing Zhang, Zhanhao Lu, Lian-Feng Li, Yong-Hui Zheng, Li Pan, Jing Lan, Huanjie Zhai, Shujian Huang, Yuan Sun, Hua-Ji Qiu
Summary: In this study, MGF300-2R was identified as a key factor for replication and pathogenicity of African swine fever virus (ASFV). MGF300-2R promotes the K27-linked ubiquitination of IKKα and IKKβ for TOLLIP-dependent autophagic degradation, suppressing the activation of the NF-κB signaling pathway. These findings highlight the relevance of the inflammatory response in ASFV virulence and suggest MGF300-2R as a potential target for vaccine development.
Article
Virology
Pingping Zhou, Lian-Feng Li, Kehui Zhang, Bing Wang, Lijie Tang, Miao Li, Tao Wang, Yuan Sun, Su Li, Hua-Ji Qiu
Summary: This study reveals the essential role of the ASFV structural protein pH240R in virus morphogenesis. pH240R interacts with the major capsid protein p72 and is critical for the assembly of infectious particles. Deletion of pH240R leads to reduced progeny virus titer and increased production of noninfectious particles. Furthermore, pH240R deficiency induces high-level expression of inflammatory cytokines. These findings provide insights into ASFV assembly and offer a potential target for the development of vaccines and antivirals.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Tao Wang, Jun Xu, Jorge Garcia Molinos, Chao Li, Bowen Hu, Meng Pan, Min Zhang
Article
Medicine, General & Internal
Qing Quan Liu, Anying Cheng, Yiru Wang, Haifang Li, Liu Hu, Xuecheng Zhao, Tao Wang, Fan He
