期刊
GENES
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/genes9120616
关键词
circadian; post-transcriptional; RNA; splicing; RNA-binding proteins
资金
- Argentine-German grant (PROGRAMA DE COOPERACION BILATERAL, NIVEL II-MINCyT-CONICET-DFG-2013)
- German Research Foundation (DFG) [STA 653/9-1]
- Max-Planck-Society Grant
The circadian clock is an important endogenous timekeeper, helping plants to prepare for the periodic changes of light and darkness in their environment. The clockwork of this molecular timer is made up of clock proteins that regulate transcription of their own genes with a 24 h rhythm. Furthermore, the rhythmically expressed clock proteins regulate time-of-day dependent transcription of downstream genes, causing messenger RNA (mRNA) oscillations of a large part of the transcriptome. On top of the transcriptional regulation by the clock, circadian rhythms in mRNAs rely in large parts on post-transcriptional regulation, including alternative pre-mRNA splicing, mRNA degradation, and translational control. Here, we present recent insights into the contribution of post-transcriptional regulation to core clock function and to regulation of circadian gene expression in Arabidopsis thaliana.
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