Article
Multidisciplinary Sciences
Chad C. Doucette, Davide Barteselli, Daniel C. Nguyen, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, Aaron C. Brown
Summary: In this study, an optogenetic approach was used to activate UCP1-dependent thermogenesis in brown adipocytes. This system allows for precise, chemical free, temporal control of UCP1-dependent thermogenesis, which can contribute to our understanding of brown adipocyte biology and the development of therapies for obesity-related disorders.
Article
Biology
Muhammad Hamza Bokhari, Carina Halleskog, Alice Aslund, Nathalie Boulet, Eva Casadesus Rendos, Jasper Martin Anton de Jong, Robert Csikasz, Ez-Zoubir Amri, Irina Shabalina, Tore Bengtsson
Summary: The study demonstrates the crucial role of UCP1 protein in the thermogenesis of murine brown and brite adipocytes. The use of isothermal microcalorimetry is established as a sensitive and accurate technique for measuring this heat-producing response.
COMMUNICATIONS BIOLOGY
(2021)
Article
Nutrition & Dietetics
Boglarka Agnes Vinnai, Rini Arianti, Ferenc Gyory, Zsolt Bacso, Laszlo Fesus, Endre Kristof
Summary: This study investigated how the availability of extracellular thiamine affects the expression of thermogenic marker genes and proteins during adipocyte differentiation. Higher thiamine levels led to increased expression of thiamine transporters and enhanced thermogenic competency in differentiated adipocytes from the neck area. Gradually increasing concentrations of thiamine resulted in elevated mitochondrial biogenesis and thermogenic gene expression in a concentration-dependent manner.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y. Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Mueller, Anke Toenjes, Christian Schlein, Azin Jafari, Holger K. Eltzschig, Thorsten Gnad, Matthias Bluher, Natalie Krahmer, Peter Kovacs, Joerg Heeren, Alexander Pfeifer
Summary: This study reveals that inosine, a metabolite released during apoptosis, enhances the thermogenic program in healthy adipocytes and regulates energy expenditure. The equilibrative nucleoside transporter 1 (ENT1) controls inosine levels in brown adipose tissue, affecting thermogenic capacity. In humans, a loss of function mutation in ENT1 is associated with lower body mass index and reduced odds of obesity.
Review
Nutrition & Dietetics
Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang
Summary: Brown and beige adipocytes have the ability to generate heat and can be activated by various methods. Understanding the molecular mechanisms of their differentiation and function is crucial for developing clinical therapies. Drugs and nutritional interventions can activate these adipocytes while minimizing potential side effects.
Article
Biochemistry & Molecular Biology
Tingting Jiang, Duo Su, Xin Liu, Yan Wang, Linjie Wang
Summary: This study found that FGF11 is enriched in brown adipose tissue of goats and promotes differentiation and thermogenesis in brown adipocytes by promoting UCP1 gene expression through EBF2 binding to the UCP1 promoter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Xiaoyi Ma, Huanhuan Yan, Shubin Hong, Shuang Yu, Yingying Gong, Dide Wu, Yanbing Li, Haipeng Xiao
Summary: This study found that gamma-aminobutyric acid (GABA) promotes the beiging process of inguinal white adipose tissue (iWAT) by improving the gut microbiota composition, thereby reducing obesity. Specifically, GABA reduced body weight and adipose inflammation and promoted the expression of thermogenic genes in the iWAT. Moreover, GABA altered the gut microbiota composition and metabolite levels in obese mice. The findings suggest that GABA may promote iWAT beiging through the gut microbiota, protecting obese individuals against metabolic abnormalities caused by obesity and gut dysbiosis.
Review
Endocrinology & Metabolism
Ruping Pan, Yong Chen
Summary: Obesity is characterized by the overaccumulation of white adipose tissue in the body, leading to various metabolic disorders. Targeting human thermogenic adipose tissues shows promise in combating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Shanshan Chen, Minglu Xu, Min Zhou, Yingxin He, Yongchun Li, Hui Lang, Xuliang Wei, Lijie Yan, Hongde Xu
Summary: The study found that Hibiscus manihot may reduce obesity in mice by changing the composition of the gut microbiota and activating UCP1 to increase thermogenesis of brown fat, making it a potential drug for treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Laura Niiranen, Kari A. Makela, Shivaprakash J. Mutt, Riikka Viitanen, Anna Kaisanlahti, David Vicente, Tommi Noponen, Anu Autio, Anne Roivainen, Pirjo Nuutila, Seppo Saarela, Karl-Heinz Herzig
Summary: The raccoon dog does not seem to induce brown adipose tissue or recruit beige adipocytes for thermogenesis during the winter, as evidenced by PET/CT imaging and lack of change in UCP1 expression in response to chronic treatments. Instead, it relies on its thick fur coat, insulating fat, and muscle shivering to provide the necessary heat for survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Minh-Hanh Thi Nguyen, Dat Da Ly, Nhung Thi Nguyen, Xu-Feng Qi, Hyon-Seung Yi, Minho Shong, Seung-Kuy Cha, Sangkyu Park, Kyu-Sang Park
Summary: Short-term exposure to T-3 induces UCP1 upregulation and mitochondrial activation in brown adipocytes through PLC-mediated elevation of [Ca2+].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Avi Lerner, Drashti Kewada, Ayan Ahmed, Kate Hardy, Mark Christian, Stephen Franks
Summary: Polycystic ovary syndrome (PCOS) is associated with reduced postprandial thermogenesis and abnormalities in adipose tissue function, with excess androgen inhibiting brown adipogenesis, attenuating thermogenic activation, and reducing mitochondrial respiration in brown adipose tissue (BAT). These findings may contribute to the reduced postprandial thermogenesis and increased tendency to obesity observed in women with PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Dingyuan Tian, Xiaojiao Zeng, Yihui Gong, Yin Zheng, Jun Zhang, Zhongming Wu
Summary: This study investigated the role of histone deacetylase 1 (HDAC1) in obesity and found that HDAC1 inhibits thermogenesis in beige adipocytes. By regulating histone crotonylation levels, it is possible to increase energy expenditure and treat obesity and related metabolic disorders.
CELLULAR SIGNALLING
(2023)
Article
Food Science & Technology
Stefanie F. Maurer, Sebastian Dieckmann, Jens Lund, Tobias Fromme, Anne Lundby Hess, Cecilia Colson, Louise Kjolbaek, Arne Astrup, Matthew Paul Gillum, Lesli Hingstrup Larsen, Gerhard Liebisch, Ez-Zoubir Amri, Martin Klingenspor
Summary: The study suggests that dietary fish oil supplementation may enhance the recruitment of thermogenic capacity in adipocytes, but does not significantly affect body weight or adiposity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Gabriella von Essen, Erik Lindsund, Elaina M. Maldonado, Petr Zouhar, Barbara Cannon, Jan Nedergaard
Summary: This study examines the possibility of countering obesity by activating brown or beige adipose tissue and UCP1. The findings show that although UCP1 protein may increase, it is not necessarily utilized for diet-induced thermogenesis. Constant activation of UCP1 is required to effectively ameliorate obesity development.
MOLECULAR METABOLISM
(2023)
Article
Endocrinology & Metabolism
Catalina Pico, Mariona Palou, Catalina Amadora Pomar, Ana Maria Rodriguez, Andreu Palou
Summary: Leptin, primarily produced by adipose tissue, plays a crucial role in controlling lipid reserves and regulating energy homeostasis. It exerts regulatory actions at various levels and has important effects on the development and function of adipose tissue. Understanding how leptin regulates adipose tissue can provide insights into the pathophysiology of obesity and related diseases.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Nutrition & Dietetics
Catalina Pico, Mariona Palou
Article
Nutrition & Dietetics
Sebastia Galmes, Andreu Palou, Francisca Serra
Summary: This study evaluates micronutrient intakes in Spain and their relationship with COVID-19 epidemiological indicators. The results show insufficient intakes of vitamin D, A, B-9, and zinc in Spain, and these inadequate intakes are associated with higher COVID-19 incidence and mortality rates in certain regions.
Article
Medicine, General & Internal
Mona Adnan Aldubayan, Kristina Pigsborg, Sophia M. O. Gormsen, Francisca Serra, Mariona Palou, Pedro Mena, Mart Wetzels, Alberto Calleja, Antoni Caimari, Josep Del Bas, Biotza Gutierrez, Faidon Magkos, Mads Fiil Hjorth
Summary: Personalised nutrition has great potential in preventing and treating diet-related diseases, such as obesity. This study aims to compare the health outcomes of a personalised nutritional plan with a standard approach based on general dietary recommendations in subjects with overweight or obesity. The study is a 10-week parallel, double-blinded randomised intervention trial, with the primary outcome being the difference in fat mass change between the personalised and control groups.
Article
Biochemistry & Molecular Biology
Pere Bibiloni, Catalina A. Pomar, Andreu Palou, Juana Sanchez, Francisca Serra
Summary: Elevated miR-222 levels are linked to metabolic syndrome, insulin resistance, and diabetes. Rats fed an obesogenic diet during lactation have higher miR-222 content in breast milk, leading to increased body fat mass and impaired insulin sensitivity in their offspring. Transfection experiments with miR-222 mimics or inhibitors on 3T3-L1 preadipocytes reveal that miR-222 plays a role in pathways related to insulin signaling, lipid metabolism, and adipogenesis.
Article
Nutrition & Dietetics
Pedro Castillo, Catalina Amadora Pomar, Andreu Palou, Mariona Palou, Catalina Pico
Summary: The study aimed to analyze the long-term metabolic effects of leptin supplementation during suckling in the offspring of diet-induced obese rats and the potential benefits of improving maternal diet during lactation. The results showed that leptin treatment significantly improved metabolic profile and body fat accumulation under standard diet conditions, with stronger effects in male offspring. However, under high-fat diet conditions, the offspring of dams fed as high-fat diet showed metabolic alterations that were not observed in the offspring of dams switched to standard diet during lactation. Leptin supplementation improved glucose homeostasis in male offspring but impaired insulin sensitivity in female offspring born to high-fat diet-fed dams. These findings highlight the importance of balanced maternal diet during the perinatal period, especially lactation, for the metabolic health of offspring, and the beneficial effects of leptin supplementation during suckling, particularly in male offspring.
Article
Biochemistry & Molecular Biology
Pedro Castillo, Ondrej Kuda, Jan Kopecky, Catalina Amadora Pomar, Andreu Palou, Mariona Palou, Catalina Pico
Summary: The study evaluated the impact of improving maternal diet during lactation on the metabolome of milk and offspring plasma in diet-induced obese rats. The results showed that the milk of rats fed a western diet had altered amino acid and carnitine profiles, as well as changes in other metabolites. These alterations were also observed in the plasma of the offspring, but were largely normalized in rats that switched to a standard diet during lactation.
Article
Nutrition & Dietetics
Marta Alonso-Bernaldez, Andreu Palou-March, Rocio Zamanillo-Campos, Andreu Palou, Mariona Palou, Francisca Serra
Summary: Although nutrient profiling systems are helpful for healthier food choices, assessing overall diet quality is still necessary. This study developed a diet profiling algorithm (DPA) to evaluate nutritional quality, giving a final score and color coding. The DPA considers various factors such as carbohydrate/fiber ratio and energy from saturated fats and sodium, as well as fiber, protein, and macronutrient distribution.
Article
Biochemistry & Molecular Biology
Sebastia Galmes, Andreu Palou, Francisca Serra
Summary: The study found that suboptimal vitamin A intake is associated with cardiometabolic risk, with differences observed between sexes and genetic backgrounds. The findings highlight the importance of personalized nutritional advice regarding vitamin A and cardiometabolic risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Catalina Pico, Empar Lurbe, Jaap Keijer, Jan Kopecky, Jean-Francois Landrier, Julio Alvarez-Pitti, Jean Charles Martin, Paula Oliver, Andreu Palou, Mariona Palou, Petr Zouhar, Joan Ribot, Ana M. Rodriguez, Juana Sanchez, Francisca Serra, M. Luisa Bonet
Summary: The objective of the INTEGRActiv study is to identify novel integrative biomarkers of PA and its effects on body health in children and adolescents, and to validate these biomarkers through an educational intervention.
FRONTIERS IN PEDIATRICS
(2023)
Article
Food Science & Technology
Catalina A. Pomar, Tomeu Viver, Ana Valle, Juan F. Gago, Pedro Castillo, Mariona Palou, Andreu Palou, Ramon Rossello-Mora, Catalina Pico
Summary: Maternal consumption of an obesogenic diet during the perinatal period results in changes in the microbiome of dams, which are alleviated by dietary improvement during lactation. Maternal conditions and leptin supplementation of pups during suckling have a modest impact on shaping the microbiome of the adult offspring, which might partially contribute to the adverse and beneficial effects, respectively, of these conditions on programmed metabolic health.
