Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells

Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification

(2017) Arkady Rutkovskiy et al.   Journal of the American Heart Association

In vitro models of aortic valve calcification: solidifying a system

(2015) Meghan A. Bowler et al.   CARDIOVASCULAR PATHOLOGY

Calcification in Aortic Stenosis

(2015) Tania A. Pawade et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-κB pathway in BMP-2 expression

(2014) Dong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Augmented Osteogenic Responses in Human Aortic Valve Cells Exposed to oxLDL and TLR4 Agonist: A Mechanistic Role of Notch1 and NF-κB Interaction

(2014) Qingchun Zeng et al.   PLoS One

Biomechanical factors in the biology of aortic wall and aortic valve diseases

(2013) Magnus Bäck et al.   CARDIOVASCULAR RESEARCH

Strain Magnitude-Dependent Calcific Marker Expression in Valvular and Vascular Cells

(2013) Zannatul Ferdous et al.   CELLS TISSUES ORGANS

Cross-Talk Between the Toll-Like Receptor 4 and Notch1 Pathways Augments the Inflammatory Response in the Interstitial Cells of Stenotic Human Aortic Valves

(2012) Q. Zeng et al.   CIRCULATION

Cellular Mechanisms of Aortic Valve Calcification

(2012) Jane A. Leopold   Circulation-Cardiovascular Interventions

Inflammation Is Associated with the Remodeling of Calcific Aortic Valve Disease

(2012) Nancy Coté et al.   INFLAMMATION

Heart Valve Structure and Function in Development and Disease

(2011) Robert B. Hinton et al.   Annual Review of Physiology

The aortic valve microenvironment and its role in calcific aortic valve disease

(2011) Cindy Ying Yin Yip et al.   CARDIOVASCULAR PATHOLOGY

Calcific Aortic Valve Disease: Not Simply a Degenerative Process

(2011) Nalini M. Rajamannan et al.   CIRCULATION

Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease

(2011) Jan-Hung Chen et al.   CIRCULATION RESEARCH

Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms

(2011) Jordan D. Miller et al.   CIRCULATION RESEARCH

Viral and bacterial patterns induce TLR-mediated sustained inflammation and calcification in aortic valve interstitial cells

(2011) Javier López et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner

(2010) Kartik Balachandran et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor Necrosis Factor-  Accelerates the Calcification of Human Aortic Valve Interstitial Cells Obtained from Patients with Calcific Aortic Valve Stenosis via the BMP2-Dlx5 Pathway

(2010) Z. Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mechanical Strain and the Aortic Valve: Influence on Fibroblasts, Extracellular Matrix, and Potential Stenosis

(2009) Sven Lehmann et al.   ANNALS OF THORACIC SURGERY

Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

(2009) Cindy Ying Yin Yip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Microfilaments Facilitate TLR4-Mediated ICAM-1 Expression in Human Aortic Valve Interstitial Cells

(2009) Yong Song et al.   JOURNAL OF SURGICAL RESEARCH

Pro-Osteogenic Phenotype of Human Aortic Valve Interstitial Cells Is Associated With Higher Levels of Toll-Like Receptors 2 and 4 and Enhanced Expression of Bone Morphogenetic Protein 2

(2009) Xiaoping Yang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: Role of Smad1 and extracellular signal-regulated kinase 1/2

(2009) Xiaoping Yang et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease

(2009) Tatiana V. Tkatchenko et al.   PHYSIOLOGICAL GENOMICS

Lipopolysaccharide Stimulation of Human Aortic Valve Interstitial Cells Activates Inflammation and Osteogenesis

(2008) Ashok N. Babu et al.   ANNALS OF THORACIC SURGERY

Regulation of valvular interstitial cell calcification by components of the extracellular matrix

(2008) Karien J. Rodriguez et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis

(2007) Xianzhong Meng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY