Article
Clinical Neurology
Li Ma, Jiancheng Zhang, Yuko Fujita, Hiroyo Shinno-Hashimoto, Jiajing Shan, Xiayun Wan, Youge Qu, Lijia Chang, Xingming Wang, Kenji Hashimoto
Summary: This study found that the splenic nerve plays a role in inflammation-related depression and microglial activation in the hippocampus, and that the gut microbiota may regulate microglial function in the brain via the gut-microbiota-brain axis.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Food Science & Technology
Qiu-Ping Zhang, Jie Cheng, Qing Liu, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Yi
Summary: Dendrobium officinale polysaccharides (DOP) can alleviate perimenopausal depression symptoms by modulating gut microbiota-neuroinflammation and restoring the hypothalamic-pituitary-adrenal (HPA) axis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Immunology
Songji Li, Wenyu Cao, Shifen Zhou, Minhui Ma, Wenjuan Zhang, Fang Li, Changqi Li
Summary: Recent research has found that genetic variants of Cntn1 are linked to major depressive disorders. Overexpression of Cntn1 in the hippocampus triggers anxiety- and depression-like phenotypes, microglia activation, and reduced immature neurons in the hippocampus. These findings suggest that Cntn1 plays a role in regulating anxiety and depression through functional actions in the hippocampus.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Pharmacology & Pharmacy
Xiaoheng Li, Zhixin Peng, Lingling Jiang, Ping Zhang, Pin Yang, Zengqiang Yuan, Jinbo Cheng
Summary: Chronic stress exposure can lead to dysregulation of the immune system and activation of microglia, resulting in depression-like symptoms. The study found that Dlg1 knockout in microglia can alleviate depression-like behavior induced by chronic stress, by reversing microglial activation and morphological changes. This finding provides a potential target for the treatment of clinical depression.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Hai-long Yang, Meng-Meng Li, Man-Fei Zhou, Huai-Sha Xu, Fei Huan, Na Liu, Rong Gao, Jun Wang, Ning Zhang, Lei Jiang
Summary: This study investigated the mechanisms of depression induced by chronic restraint stress from the perspectives of inflammation, gut microbiota, and neurotransmitters. It was found that CRS led to inflammatory reactions, disturbances in neurotransmitter metabolism, and dysbiosis in gut microbiota. The study suggests potential links between microbiota dysbiosis and neurotransmitter metabolism in CRS-induced depression, providing new strategies for depression treatment.
Article
Neurosciences
Junnan Li, Yannan Li, Wenzhe Duan, Zhonghui Zhao, Lixuan Yang, Wei Wei, Jingchun Li, Yang Li, Yao Yu, Baoan Dai, Rongjuan Guo
Summary: Shugan Granule improves altered behavior and hippocampal inflammation in rats by targeting the PI3K/Akt/mTOR pathway through altering gut microbiota and metabolites.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Immunology
Jeremy Alloo, Ines Leleu, Corinne Grangette, Sylviane Pied
Summary: Parasitic infections can lead to brain inflammation, disrupting glial cell activity and the integrity of the blood-brain barrier. Changes in the gut microbiota may influence the severity of the central nervous system's inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Lanxiang Liu, Haiyang Wang, Xuechen Rao, Ying Yu, Wenxia Li, Peng Zheng, Libo Zhao, Chanjuan Zhou, Juncai Pu, Deyu Yang, Liang Fang, Ping Ji, Jinlin Song, Hong Wei, Peng Xie
Summary: The study revealed that gut microbiota dysbiosis induces changes in acetylation and succinylation of proteins in the mouse hippocampus, primarily involving carbon metabolism, gene transcription, synaptic vesicle cycle, and protein translation. Furthermore, gut microbiota dysbiosis may also trigger depressive-like behaviors by affecting mitochondria-mediated biological processes and the MAPK signaling pathway.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xiaoxu Zhu, Qingyu Ma, Furong Yang, Xiaojuan Li, Yueyun Liu, Jianbei Chen, Lan Li, Man Chen, Xiaojuan Zou, Li Yan, Jiaxu Chen
Summary: XYS alleviates depression-like phenotypes in CRS rats by inhibiting A2AR in the striatum.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yuanyuan Deng, Manfei Zhou, Junfeng Wang, Jiaxi Yao, Jing Yu, Wenwei Liu, Linlin Wu, Jun Wang, Rong Gao
Summary: The research found that long-term stress disrupts Kyn metabolism and endocrine function, accompanied by disrupted homeostasis of certain microbiota, collectively contributing to the development of depression-like behavior.
Article
Immunology
Jing Xia, Li Gu, Yitong Guo, Hongyan Feng, Shuhan Chen, Jessore Jurat, Wenjing Fu, Dongfang Zhang
Summary: Dietary capsaicin was found to improve depressive-like behaviors and restore abnormal changes in depression-related microbiota in LPS-induced mice, indicating its potential in regulating gut microbiota and preventing depression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Hui Li, Ningshan Li, Qudong Lu, Jun Yang, Jiang Zhao, Qiong Zhu, Shanhong Yi, Weihua Fu, Tingting Luo, Jiawei Tang, Yi Zhang, Guoliang Yang, Zheng Liu, Jie Xu, Wei Chen, Jingzhen Zhu
Summary: Studies have shown that chronic alcohol consumption disrupts the gut microbiota, leading to impaired sperm quality. The changes in gut microbiota affect metabolite levels, trigger inflammation, and result in testicular inflammation and abnormal gene expression, ultimately leading to decreased sperm quality. These findings are important for the treatment of male infertility.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Integrative & Complementary Medicine
Jianghui Hu, Jimin Ni, Junping Zheng, Yanlei Guo, Yong Yang, Cheng Ye, Xiongjie Sun, Hui Xia, Yanju Liu, Hongtao Liu
Summary: This study found that Tripterygium hypoglaucum extract can protect against rheumatoid arthritis by manipulating the gut microbiota and regulating the TLR4/ MyD88/ MAPK signaling pathway. Additionally, treatment with Tripterygium hypoglaucum extract failed to improve arthritis symptoms and signaling pathways in pseudo germ-free mice, further validating the importance of the gut microbiota.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Review
Biochemistry & Molecular Biology
Lukasz Lassmann, Matteo Pollis, Agata Zoltowska, Daniele Manfredini
Summary: This review study found a link between sleep disorders and gastroenterological disorders with depression and chronic orofacial pain. Sleep disorders and gastroenterological disorders negatively affect the psyche, increase inflammation, disrupt tryptophan metabolism, and cause excessive microglial activation, leading to increased susceptibility to pain sensation and depression.
Article
Multidisciplinary Sciences
C. E. Matisz, M. Patel, N. S. Hong, R. J. McDonald, A. J. Gruber
Summary: Chronic inflammatory diseases are often associated with anxiety in humans. This study found that prolonged gut inflammation is sufficient to induce anxiety-related behaviors in mice. The research suggests that chronic inflammation may affect memory consolidation processes, leading to the generalization of negative associations and fearful responses in inappropriate contexts.
SCIENTIFIC REPORTS
(2022)