Review
Clinical Neurology
Xiongjie Fu, Guoyang Zhou, Jianfeng Zhuang, Chaoran Xu, Hang Zhou, Yucong Peng, Yang Cao, Hanhai Zeng, Jianru Li, Feng Yan, Lin Wang, Gao Chen
Summary: Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity, mortality, and disability rates. Research indicates that the development of white matter injury (WMI) following ICH is complex and determines the prognosis of patients. Comprehensive treatment and understanding the relationship between WMI and other brain cells may reveal therapeutic targets for ICH.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Heng Yang, Wei Ni, Pengju Wei, Sicheng Li, Xinjie Gao, Jiabin Su, Hanqiang Jiang, Yu Lei, Liangfu Zhou, Yuxiang Gu
Summary: Inhibition of HDACs can reduce neuroinflammation and white matter damage after ICH by modulating microglia/macrophage polarization, leading to improved neurological functional recovery.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Immunology
Jingwei Zheng, Jia'nan Lu, Shuhao Mei, Haijian Wu, Zeyu Sun, Yuanjian Fang, Shenbin Xu, Xiaoyu Wang, Ligen Shi, Weilin Xu, Sheng Chen, Jun Yu, Feng Liang, Jianmin Zhang
Summary: CeNP treatment alleviates white matter injury induced by ICH by modulating ROS-induced microglial polarization and astrocyte alteration. CeNP promotes remyelination and OPC differentiation, while inhibiting the expression of M1 microglia and A1 astrocyte. The findings suggest that CeNP could be a potential therapeutic strategy for white matter injury.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Critical Care Medicine
Mengying Yu, Dongqin Zhu, Zhixian Luo, Zhifang Pan, Yunjun Yang, Haoli Xu
Summary: This study aimed to investigate the correlation between white matter lesion (WML) severity and delayed intraventricular hemorrhage (IVH) in patients with intracerebral hemorrhage (ICH), as well as the association between WML and baseline IVH. The results showed that moderate-severe WML was an independent risk factor for both delayed IVH and baseline IVH.
NEUROCRITICAL CARE
(2022)
Article
Neurosciences
Jing Li, Jianhao Liang, Meiqin Zeng, Kaijian Sun, Yunhao Luo, Huaping Zheng, Feng Li, Wen Yuan, Hongwei Zhou, Junshan Liu, Haitao Sun
Summary: This study demonstrates that oxymatrine improves white matter injury and neurological deficits caused by intracerebral hemorrhage by modulating the gut microbiota.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Xiongjie Fu, Guoyang Zhou, Xinyan Wu, Chaoran Xu, Hang Zhou, Jianfeng Zhuang, Yucong Peng, Yang Cao, Hanhai Zeng, Yin Li, Jianru Li, Liansheng Gao, Gao Chen, Lin Wang, Feng Yan
Summary: Our study revealed that inhibiting P2X4R can promote neurofunctional recovery after ICH, transform pro-inflammatory microglia induced by ICH into an anti-inflammatory phenotype, and alleviate ICH-induced WMI. Additionally, TrkB blockage can reverse the protective effects of WMI, suggesting that P2X4R plays a crucial role in regulating WMI and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Jingyin Chen, Sravanthi Koduri, Shuhui Dai, Yasunori Toyota, Ya Hua, Neeraj Chaudhary, Aditya S. Pandey, Richard F. Keep, Guohua Xi
Summary: The study found that white matter fibers may persist within the hematoma after intracerebral hemorrhage, and macrophages/microglia may use these fibers as a scaffold to infiltrate into the hematoma and aid in hematoma clearance.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ekaterina Vasilevskaya, Aleksandr Makarenko, Galina Tolmacheva, Irina Chernukha, Anastasiya Kibitkina, Liliya Fedulova
Summary: The study conducted a comprehensive short-term study on the development of cerebrovascular disorders in rats with an intracerebral hematoma model. The overall lethality of the model was 43.7% and it reflects the main diagnostic criteria for acute disorders of cerebral circulation.
Article
Biochemistry & Molecular Biology
Nemanja Novakovic, Joseph R. Linzey, Thomas L. Chenevert, Joseph J. Gemmete, Jonathan P. Troost, Guohua Xi, Richard F. Keep, Aditya S. Pandey, Neeraj Chaudhary
Summary: This study attempts to quantify white matter injury within and surrounding hematomas after mild to moderate ICH using DTI MRI, showing varying degrees of changes in white matter injury over time, with a correlation to hematoma size.
Review
Geriatrics & Gerontology
Jing Li, Linglong Xiao, Dian He, Yunhao Luo, Haitao Sun
Summary: Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke with high disability and high mortality rates. White matter injury (WMI) caused by intracerebral parenchymal hemorrhage is closely associated with poor prognosis after ICH, and mesenchymal stem cells (MSCs) may serve as potential therapeutic targets.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Min Yao, Jie Fang, Jiewei Li, Anson Cho Kiu Ng, Jiaxin Liu, Gilberto Ka Kit Leung, Fanglai Song, Jian Zhang, Chunqi Chang
Summary: This study reveals that targeting PTP sigma can improve white matter integrity and sensorimotor recovery in patients with ICH. The study also found that ISP treatment can reduce WM injury in the peri-hematomal region, enhance axonal myelination, and facilitate sensorimotor function restoration as assessed by electrophysiology.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Engineering, Biomedical
Xinjie Gao, Heng Yang, Weiping Xiao, Jiabin Su, Yuwen Zhang, He Wang, Wei Ni, Yuxiang Gu
Summary: The study found that SIRP alpha-v Exos accelerated the clearance of hematoma and improved neurological function in patients with ICH. Additionally, SIRP alpha-v Exos promoted polarization of microglia/macrophages and recruited regulatory T cells. The experiments demonstrated the therapeutic effects of SIRP alpha-v Exos in treating ICH by regulating microglia/macrophages.
BIOMATERIALS RESEARCH
(2022)
Article
Neurosciences
Nemanja Novakovic, Zachary M. Wilseck, Thomas L. Chenevert, Guohua Xi, Richard F. Keep, Aditya S. Pandey, Neeraj Chaudhary
Summary: This study investigated the time course of red blood cell lysis in ICH patients using MRI, revealing correlations between perihematomal iron accumulation and white matter loss with erythrolysis extent and hematoma volume in the early and subacute periods after ICH. MRI may be a reliable tool for assessing hematoma lysis over time and its impact on surrounding tissues.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Xuejiao Lei, Quan Hu, Hongfei Ge, Xuyang Zhang, Xufang Ru, Yujie Chen, Rong Hu, Hua Feng, Jun Deng, Yan Huang, Wenyan Li
Summary: This study successfully addresses two challenges in neural stem cell transplantation therapy for intracerebral hemorrhage - low survival rate and uncontrolled differentiation - by designing a nanogel system, promoting white matter regeneration and improving behavioral performance in ICH mice.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Xiaodong Ye, Yuchao Jia, Guini Song, Xiaoyan Liu, Chuyue Wu, Guo Li, Xu Zhao, Xiong Wang, Shanshan Huang, Suiqiang Zhu
Summary: This study aimed to investigate the risk factors for the multispot pattern in intracerebral hemorrhage (ICH) related to cerebral small vessel disease (CSVD). The results showed that possession of APOE ε2 and severe CSO-PVS were independently associated with the multispot pattern, which has potential diagnostic significance for cerebral amyloid angiopathy (CAA).
TRANSLATIONAL STROKE RESEARCH
(2022)