Article
Veterinary Sciences
Marina Betancor, Belen Marin, Alicia Otero, Carlos Hedman, Antonio Romero, Tomas Barrio, Eloisa Sevilla, Jean-Yves Douet, Alvina Huor, Juan Jose Badiola, Olivier Andreoletti, Rosa Bolea
Summary: The transmission of atypical scrapie to cattle can lead to the emergence of BSE-like prion seeding activity, even though the infected cattle did not show clinical signs of prion disease.
VETERINARY RESEARCH
(2023)
Article
Virology
Brent Race, Katie Williams, Chase Baune, James F. Striebel, Clayton W. Winkler, James A. Carroll, Sandra E. Encalada, Bruce Chesebro
Summary: The study did not find any differences in PrPSc spread, distribution, or survival times between KIF5C knock-out mice and control mice.
Article
Microbiology
Akikazu Sakudo, Daiki Anraku, Tomomasa Itarashiki
Summary: The study showed that vaporized gas derived from a hydrogen peroxide-peracetic acid mixture can effectively inactivate prions and prolong the survival time of mice injected with prion samples. This method may be applied to the sterilization of contaminated heat-sensitive medical devices.
Review
Pharmacology & Pharmacy
Daniela Maria Tanase, Alina Georgiana Apostol, Claudia Florida Costea, Claudia Cristina Tarniceriu, Ionut Tudorancea, Minela Aida Maranduca, Mariana Floria, Ionela Lacramioara Serban
Summary: Arterial hypertension is a prevalent disease characterized by increased incidence and heterogeneous pathophysiology. Oxidative stress plays an important role in its development, with excessive levels causing vascular cell damage and promoting hypertension. Transcription factors such as Nrf2 mediate antioxidant response pathways and provide protection.
Article
Fisheries
Yun Wang, Yafei Duan, Jianhua Huang, Jun Wang, Chuanpeng Zhou, Shigui Jiang, Heizhao Lin, Zhe Zhang
Summary: PmNrf2, a member of CNC-bZIP transcription factor family, is constitutively expressed in various tissues of shrimp and responds to bacterial challenge. Knockdown of PmNrf2 results in decreased expression of PmGPx gene, indicating its role in regulating the transcription of antioxidant enzyme genes in shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Mari Nakaie, Fumihiro Katayama, Takehiro Nakagaki, Masao Kawasaki, Sakura Yoshida, Akira Toriba, Kazuma Ogawa, Noriyuki Nishida, Morio Nakayama, Takeshi Fuchigami
Summary: This study developed new compounds for imaging PrPSc deposits in the brain. These compounds showed binding affinity for PrPSc aggregates, but improvements in binding affinity and blood-brain barrier permeability are necessary.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Cell Biology
Chae Kim, Tracy Haldiman, Sang-Gyun Kang, Lenka Hromadkova, Zhuang Zhuang Han, Wei Chen, Frances Lissemore, Alan Lerner, Rohan de Silva, Mark L. Cohen, David Westaway, Jiri G. Safar
Summary: This study suggests that the variability in Alzheimer's disease progression could be attributed to different structural assemblies of TAU protein. Specifically, the rapidly replicating, misfolded TAU conformers found in rapidly progressive AD may drive the rapid decline in the disease. This finding implies that effective therapeutic strategies for AD might need to consider the diverse misfolded TAU conformers rather than a singular species.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Microbiology
Pascal Leblanc, Ina Maja Vorberg
Summary: Neurodegenerative diseases are fatal neurological diseases that may be associated with viral infections, which can lead to neuroinflammation and disruption of neuronal protein quality control, affecting the formation and spread of diseases.
Article
Biochemistry & Molecular Biology
Savroop Bhamra, Parineeta Arora, Szymon W. Manka, Christian Schmidt, Craig Brown, Melissa L. D. Rayner, Peter-Christian Klohn, Anthony R. Clarke, John Collinge, Parmjit S. Jat, Louise C. Serpell
Summary: The N-terminal residues within PrPC, specifically amino acids 105-111 in CC2, are necessary for the propagation of four different mouse prion strains. These residues mediate the ordering of unstructured CC2 into infectious prion fibrils.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura Janko, Emese Toth, Miklos Laczik, Boglarka Rauch, Eszter Janka, Balint L. Balint, Peter Bai
Summary: PARP2 plays a role in DNA repair and has regulatory functions in mitochondrial and lipid metabolism. It is also involved in the adverse effects of pharmacological PARP inhibitors. Silencing of PARP2 affects the subcellular localization of NRF2, a regulator of cellular antioxidant defense, and leads to changes in the expression of genes encoding proteins with antioxidant function.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Rabab S. Hamad, Hayder M. Al-kuraishy, Athanasios Alexiou, Marios Papadakis, Eman A. Ahmed, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: COVID-19 is a recent pandemic caused by SARS-CoV-2, leading to pulmonary and extra-pulmonary manifestations. Inhibition of Nrf2 may contribute to oxidative stress and hyperinflammation in COVID-19. Nrf2 pathway suppresses pro-inflammatory cytokines, reducing pulmonary symptoms. Nrf2 activators can improve endothelial dysfunction, RAS dysregulation, immune thrombosis, and coagulopathy.
CELL STRESS & CHAPERONES
(2023)
Review
Medicine, Research & Experimental
Marjan Talebi, Mohammad Mehdi Sadoughi, Seyed Abdulmajid Ayatollahi, Elaheh Ainy, Roghayeh Kiani, Alireza Zali, Mirmohammad Miri
Summary: CBD, a non-psychoactive cannabinoid, has been found to have numerous therapeutic benefits and is closely associated with the Nrf2 signaling pathway. Nrf2 is linked to various health issues including cardiovascular dysfunctions, cancers, and neurodegenerative conditions. Understanding the relationship between CBD and Nrf2 is of great interest in the medical field and could significantly impact the treatment and prevention of a wide range of health conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Yusuf Ayikgoz, Mehmet Salih Aydin, Nazim Kankilic, Ebru Temiz
Summary: During cardiopulmonary bypass, TNF-alpha, Nrf2, and HO-1 gene expressions increase, and these values decrease postoperatively. This indicates that oxidative stress and inflammatory processes start with cardiopulmonary bypass, and antioxidant processes start similarly.
Article
Biochemistry & Molecular Biology
Liqiang Qiu, Xiaoxiong Liu, Hao Xia, Changwu Xu
Summary: Increasing evidence suggests that PCAF plays a key role in vascular aging. Downregulation of PCAF can alleviate vascular aging by activating Nrf2 and reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qian Zeng, Tingting Zhou, Feiyan Zhao, Dayan Xiong, Bin He, Qingzhong Hua, Miao Lin, Lang Deng, Xiaoxue Sang, Weixi Xie, Jia Chen, Zun Wang, Lu Ren, Ziqiang Luo, Xiaoting Huang, Wei Liu, Siyuan Tang
Summary: Bergenin can alleviate pulmonary fibrosis by relieving oxidative stress, reducing extracellular matrix deposition, and inhibiting the formation of myofibroblasts. Furthermore, a regulatory loop between p62 and Nrf2 is formed, which is important for the therapeutic effects of bergenin on pulmonary fibrosis.
Editorial Material
Cardiac & Cardiovascular Systems
Camille L. Hancock Friesen, Tarique Hussain
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Markus Henningsson, Shaihan Malik, Rene Botnar, Daniel Castellanos, Tarique Hussain, Tim Leiner
Summary: This review provides an overview of the physics and different techniques used to achieve black-blood contrast in MRI, as well as the technical challenges related to flow and motion conditions, additional contrast weighting mechanisms, tissue magnetic properties, and spatial coverage. Specific implementations of black-blood contrast for different vascular beds are also described.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Animesh Tandon, Navina Mohan, Cory Jensen, Barbara E. U. Burkhardt, Vasu Gooty, Daniel A. Castellanos, Paige L. McKenzie, Riad Abou Zahr, Abhijit Bhattaru, Mubeena Abdulkarim, Alborz Amir-Khalili, Alireza Sojoudi, Stephen M. Rodriguez, Jeanne Dillenbeck, Gerald F. Greil, Tarique Hussain
Summary: By training and improving the CNN algorithm on rTOF patients, significant improvements in generating contours for both the left and right ventricles were achieved. The combined use of spatial metrics and volumetric comparisons provided further insights into algorithm errors.
PEDIATRIC CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Werner Budts, Owen Miller, Sonya Babu-Narayan, Wei Li, Emanuela Valsangiacomo Buechel, Alessandra Frigiola, Annemien van den Bosch, Beatrice Bonello, Luc Mertens, Tarique Hussain, Victoria Parish, Gilbert Habib, Thor Edvardsen, Tal Geva, Jolien W. Roos-Hesselink, Katarina Hanseus, Laura Dos Subira, Helmut Baumgartner, Michael Gatzoulis, Giovanni Di Salvo
Summary: The paper discusses the use of various imaging modalities in adult congenital heart disease patients, focusing on moderate to complex anatomical defects. However, there is a lack of knowledge on imaging modalities for simple shunt lesions. The document provides structured recommendations for atrial septal defect, ventricular septal defect, and persistent arterial duct, and aims to serve as a reference for researchers conducting imaging studies.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Thermodynamics
Tariq Hussain, Hang Xu, Ammarah Raees, Qing-Kai Zhao
Summary: This study investigates the silent characteristics of magnetized mixed convection flow in a porous medium suspended with microorganisms and nanoparticles induced by two expanded or contracted disks. The research introduces Buongiorno's model and multiple slip boundary conditions to describe the behaviors of the nanofluid. Significant findings include the contrary effects of the wall expansion ratio and magnetic parameter on microorganism profiles, opposite roles of Prandtl number and radiation parameter on heat transfer rate, and different influences of Brownian motion and thermophoresis on microorganism flux rate. It is expected that this study will contribute to understanding heat transfer mechanisms in various physical fields.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Agriculture, Dairy & Animal Science
Mazhar Hussain Mangi, Tariq Hussain, Muhammad Suhaib Shahid, Naveed Sabir, Muhammad Saleem Kalhoro, Xiangmei Zhou, Jianmin Yuan
Summary: The study found that feeding laying hens with a corn diet rich in omega-3 led to a significant increase in fat weight and higher levels of liver inflammation compared to a wheat diet. The microbial composition in the gut of hens fed with corn diet was significantly different from those fed with a wheat diet. Therefore, wheat diet may be a preferable choice for commercial layers poultry farms.
Article
Biochemistry & Molecular Biology
Haoran Wang, Tariq Hussain, Jiao Yao, Jing Li, Naveed Sabir, Yi Liao, Zhengmin Liang, Yuanzhi Wang, Yiduo Liu, Deming Zhao, Xiangmei Zhou
Summary: The study showed that koumiss treatment led to significant changes in the intestinal flora of mice, while the lungs of koumiss-treated mice exhibited severe edema, inflammatory infiltration, and pulmonary nodules when infected with M bovis. Additionally, the levels of short-chain fatty acids were lower in the koumiss-treated group, but the expression of endoplasmic reticulum stress and apoptosis-related proteins in the lungs was significantly reduced.
Article
Microbiology
Yi Liao, Chunfa Liu, Jie Wang, Yinjuan Song, Naveed Sabir, Tariq Hussain, Jiao Yao, Lijia Luo, Haoran Wang, Yongyong Cui, Lifeng Yang, Deming Zhao, Xiangmei Zhou
Summary: The inflammasome protects hosts by negatively regulating harmful cytokines during M. bovis infection, as shown in the research finding that caspase-1 activation reduces IFN-beta production by dampening cGAS-TBK1-IRF3 signaling pathway.
VETERINARY MICROBIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Sven Koehler, Tarique Hussain, Zach Blair, Tyler Huffaker, Florian Ritzmann, Animesh Tandon, Thomas Pickardt, Samir Sarikouch, Heiner Latus, Gerald Greil, Ivo Wolf, Sandy Engelhardt
Summary: This study addresses the challenges posed by the different orientations (length, width, height) in cardiac magnetic resonance images, proposing a novel unsupervised domain adaptation method that achieves stable image transformation between different orientations through attention mechanism and cycle consistency. After training on a dataset of multi-centric patient cohort, the segmentation performance for left ventricle, myocardium, and right ventricle all showed improvement.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Multidisciplinary Sciences
Faisal Rasool, Zaheer Ahmed Nizamani, Khawaja Shafique Ahmad, Fahmida Parveen, Shahzad Akbar Khan, Naveed Sabir
Summary: Poisonous plants have a significant impact on the livestock industry, leading to economic losses and various health issues for the animals. This study provides a comprehensive report on the toxic effects and mode of action of poisonous plants in Azad Jammu and Kashmir. A total of 38 plant species from 23 families were identified, with the most dominant being the Asteraceae family. Herbaceous plants were the most common form, and whole plant toxicity was reported to be the highest. The oral route of administration was found to be the most toxic, affecting organs such as the liver, gastrointestinal tract, and CNS. Fidelity level analysis identified Senecio vulgaris and Ageratum conyzoides as the most important plants in terms of toxicity. Ricinus communis was found to be the most poisonous plant based on LD50 values.
Article
Environmental Sciences
Syed Umair Anwar, Wuyi Zhang, Syed Zahid Ali Shah, Qudrat Ullah, Syed Muhammad Amir, Ammara Syed
Summary: This article examines the developmental collaboration under CPEC and finds that, except for GDP growth and poverty alleviation, all other factors related to economic development have a positive relationship with CPEC development. The results validate the hypothesis and provide guidelines for effective policies to support CPEC.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Maria Khan, Zahid Manzoor, Muhammad Rafiq, Shaukat Hussain Munawar, Muhammad Yasir Waqas, Hamid Majeed, Syed Zahid Ali Shah, Riaz Hussain, Hafiz Iftikhar Hussain, Tehreem Tahir, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Summary: This study provides scientific validation of the traditional use of Caralluma edulis for diabetes and inflammatory conditions. Methanol extract from the plant showed the highest content of bioactive compounds and exhibited the strongest anti-inflammatory and antioxidant activities. Furthermore, long-term use of Caralluma edulis at a tested dose showed antidiabetic properties.
Article
Chemistry, Multidisciplinary
Zemin Zhu, Ziaur Rahman, Muhammad Aamir, Syed Zahid Ali Shah, Sattar Hamid, Akhunzada Bilawal, Sihong Li, Muhammad Ishfaq
Summary: This study screened biologically active compounds that target the TLR4 receptor pathway and established QSAR models to predict the biological activity of these compounds. The models showed high correlation coefficients and accuracy, indicating their potential for high-throughput screening and providing insights into the mechanisms of TLR4 antagonists inhibition.
Article
Cardiac & Cardiovascular Systems
Vasu D. Gooty, Surendranath R. Veeram Reddy, Joshua S. Greer, Zachary Blair, Riad Abou Zahr, Yousef Arar, Daniel A. Castellanos, Sheena Pimplawar, Gerald F. Greil, Jeanne Dillenbeck, Tarique Hussain
Summary: The study successfully visualized the thoracic duct pathway in patients with single ventricles using cardiovascular magnetic resonance imaging techniques. The combination of different imaging sequences provided important insights for the diagnosis and intervention of lymphatic system abnormalities.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mari Nieves Velasco Forte, Sebastien Roujol, Bram Ruijsink, Israel Valverde, Phuoc Duong, Nick Byrne, Sascha Krueger, Steffen Weiss, Yousef Arar, Surendranath R. Veeram Reddy, Tobias Schaeffter, Tarique Hussain, Reza Razavi, Kuberan Pushparajah
Summary: The study aimed to evaluate the feasibility of MRI-guided catheterization in young patients with CHD using advanced visualization passive tracking techniques. The results indicated that MRI-guided catheterizations were carried out safely and is feasible in children and adults with CHD. The pSAT sequence offered robust and simultaneous high contrast visualization of the catheter and cardiac anatomy.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)