Article
Critical Care Medicine
Evelijn S. Lourijsen, Sietze Reitsma, Marleen Vleming, Gerjon Hannink, Gwijde F. J. P. M. Adriaensen, Marjolein E. Cornet, D. Rienk Hoven, Ward J. M. Videler, Jochen H. Bretschneider, Susanne M. Reinartz, Maroeska M. Rovers, Wytske J. Fokkens
Summary: This study aimed to assess the efficacy of endoscopic sinus surgery (ESS) plus medical therapy versus medical therapy alone in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The results indicated that ESS plus medical therapy was more efficacious than medical therapy alone in improving disease-specific health-related quality of life (HRQoL) in these patients.
LANCET RESPIRATORY MEDICINE
(2022)
Review
Allergy
Rik J. L. van der Lans, Claire Hopkins, Brent A. Senior, Valerie J. Lund, Sietze Reitsma
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common and burdensome chronic disease. Biologics have revolutionized the treatment of CRSwNP, but their high cost raises questions about their economic feasibility. This review discusses the socioeconomic burden of CRSwNP, compares different treatment modalities, and highlights the need for cost-effective options.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Instruments & Instrumentation
Thomas Bourhis, Francois Mouawad, Claire Szymanski, Geoffrey Mortuaire
Summary: Intranasal corticosteroid drugs are effective in improving mucosal recovery in patients with chronic rhinosinusitis with nasal polyps. While quality of life outcomes were similar between treatment groups, the nebulization group showed significantly better endoscopic scores. Studies on a larger scale are needed to confirm these findings and assess safety profiles.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Otorhinolaryngology
Arjun K. Parasher, Matt Gliksman, Daniel Segarra, Theodore Lin, Luke Rudmik, Troy Quast
Summary: In the treatment of chronic rhinosinusitis with nasal polyps, while dupilumab and endoscopic sinus surgery (ESS) may have similar clinical effectiveness, ESS remains the most cost-effective treatment option.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Surgery
Ping Ye, Shaojuan He, Shuangmei Tang, Xinyu Xie, Chen Duan, Liqiang Zhang, John W. Steinke, Larry Borish, Xuezhong Li, Xin Feng
Summary: Endoscopic sinus surgery (ESS) can improve olfactory function in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Lund-Mackay scores and Lund-Kennedy scores are correlated with olfactory function prior to surgery, while longer duration of the disease, higher blood eosinophilia, lower Lund-Mackay scores, and peripheral distribution of CT opacification are risk factors for poor olfactory prognosis.
FRONTIERS IN SURGERY
(2022)
Article
Multidisciplinary Sciences
Weigang Gan, Hongting Zhang, Fengjuan Yang, Shixi Liu, Feng Liu, Juan Meng
Summary: In Southwest China, the recurrence of nasal polyps is associated with neutrophil-mediated inflammatory response, with no significant correlation with factors like age, sex, asthma, or allergic rhinitis. The recurrent group showed significantly higher total nasal symptom score, eosinophil and neutrophil cell count, and expression levels of IFN-, IL-17A, IL-17E, and IL-18 compared to the non-recurrent group.
SCIENTIFIC REPORTS
(2021)
Article
Otorhinolaryngology
Reza Samarei, Javad Rasouli, Fatemeh Mehdikhani
Summary: The TAA-impregnated Gelfoam nasal pack showed significant efficacy in treating eosinophilic CRSwNP, especially at 12 and 18 months postoperatively.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Allergy
Claus Bachert, Ana R. Sousa, Joseph K. Han, Rodney J. Schlosser, Leigh J. Sowerby, Claire Hopkins, Jorge F. Maspero, Steven G. Smith, Oliver Kante, Despina E. Karidi-Andrioti, Bhabita Mayer, Robert H. Chan, Steve W. Yancey, Adam M. Chaker
Summary: Mepolizumab demonstrates efficacy in reducing nasal polyp size and nasal obstruction in patients with chronic rhinosinusitis with nasal polyps, regardless of comorbid asthma or aspirin-exacerbated respiratory disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Claudio Arancibia, Cristobal Langdon, Joaquim Mullol, Isam Alobid
Summary: In long-term follow-up after 12 years, CRSwNP patients showed significant improvement in nasal symptoms, nasal polyp size, olfaction, and CT findings, while no improvement was found in quality of life scores.
Article
Otorhinolaryngology
Claudio Arancibia, Cristobal Langdon, Joaquim Mullol, Isam Alobid
Summary: This study reports the long-term 12-year postoperative outcomes for chronic rhinosinusitis with nasal polyps (CRSwNP) patients. The results show significant improvement in nasal symptoms, polyp size, computed tomography, and olfaction after surgery, but no significant change in quality of life.
Article
Allergy
Claus Bachert, Joe K. Han, Martin Wagenmann, Werner Hosemann, Stella E. Lee, Vibeke Backer, Joaquim Mullol, Philippe Gevaert, Ludger Klimek, Emanuel Prokopakis, Andrew Knill, Carlo Cavaliere, Claire Hopkins, Peter Hellings
Summary: Uncontrolled severe CRSwNP can be challenging due to its association with asthma, NSAID-exacerbated respiratory disease, and allergies. The European Forum proposes structured definitions to facilitate communication among clinicians and offers a practical algorithm for defining type 2 inflammation in CRSwNP. Suggestions for evaluating treatment options, including surgery and biologics, are provided to inform patients for decision-making processes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Shuya Masuda, Saori Deguchi, Fumihiko Ogata, Joji Yoshitomi, Hiroko Otake, Kazutaka Kanai, Naohito Kawasaki, Noriaki Nagai
Summary: In this study, a 0.05% mometasone furoate (MF) nanocrystal dispersion was designed and found to enhance local absorption compared to traditional nasal MF formulations. The use of in situ gelling systems, however, attenuated the local absorption of the MF nanocrystals.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Sung-Dong Kim, Kyu-Sup Cho
Summary: Chronic rhinosinusitis is a heterogeneous disease with various clinical features. It can cause significant morbidity and costs to the healthcare system. The classification of this disease is based on the presence or absence of nasal polyps and comorbidities, as well as molecular biomarkers or specific mechanisms. Recent research has focused on three major endotypes: types 1, 2, and 3. Biological therapies targeting type 2 inflammation have shown promise and may be applicable to other inflammatory endotypes in the future. This review discusses treatment options based on the type of chronic rhinosinusitis and summarizes recent studies on new therapeutic approaches for patients with uncontrolled CRS and nasal polyps.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
Pei -Wen Wu, Cheng-Hsun Chiu, Yen -Lin Huang, Yu-Hsi Fan, Ta-Jen Lee, Chi-Che Huang, Po -Hung Chang, Chien-Chia Huang
Summary: This study aimed to elucidate the inflammatory pattern and clinical characteristics of chronic rhinosinusitis with nasal polyps (CRSwNP) related to revision surgery after endoscopic sinus surgery (ESS) in a paediatric population. By retrospectively analyzing 146 patients, including 22 who required revision surgery, it was found that the revision surgery group was significantly younger and had poorer CT features, higher tissue eosinophil infiltration, and higher immunoreactivity of inflammatory cytokines. Based on these findings, a nomogram model was developed to predict the probability of requiring revision surgery.
Article
Otorhinolaryngology
Anna Sophie Englhard, Georg Johannes Ledderose
Summary: This study aimed to identify anatomical factors that increase the need for revision surgery in a large patient collective with chronic rhinosinusitis without nasal polyps. The most common anatomic factor was incomplete anterior ethmoidectomy, followed by residual uncinated process, middle turbinate lateralization, incomplete posterior ethmoidectomy, frontal recess scarring, and middle meatal stenosis. Inadequate resection of obstructing structures during surgery seems to be a principal risk factor for recurrent chronic rhinosinusitis, and attention to the ostiomeatal complex during surgery may reduce the failure rate.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)