Review
Biochemistry & Molecular Biology
Hyunho Yoon, Sanghoon Lee
Summary: Precision oncology involves personalized treatment strategies for each cancer patient, based on genomic profiling and organoid models. Next-generation sequencing and organoid models provide accurate genetic information and clinical guidance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Jack Ruske, Gaurav Sharma, Kevin Makie, Katherine He, C. Keith Ozaki, Matthew T. Menard, Michael Belkin, Samir K. Shah
Summary: Informed consent is essential in high-quality healthcare, however, vascular surgery patients have poor comprehension of basic information related to surgical informed consent, which is associated with frailty, education level, and decisional conflict.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Oncology
Shannon M. Blee, Rachel Pocock Shah, Ana P. M. Pinheiro, Jeffrey Switchenko, Margie Dixon, Taofeek K. Owonikoko, Charles E. Hill, Stephen M. Szabo, Rebecca D. Pentz
Summary: The study found that oncologists use variable terminology to describe molecular testing, which is often not understood by patients. White participants were more likely to understand genetic testing and mutation, while patients with higher family income were also more likely to understand the terms. The results highlight the importance of developing more effective methods to explain molecular testing terminology to patients.
Review
Oncology
Manja Meggendorfer, Vaidehi Jobanputra, Kazimierz O. Wrzeszczynski, Paul Roepman, Ewart de Bruijn, Edwin Cuppen, Reinhard Buttner, Carlos Caldas, Sean Grimmond, Charles G. Mullighan, Olivier Elemento, Richard Rosenquist, Anna Schuh, Torsten Haferlach
Summary: Interrogating the tumor genome through whole-genome sequencing (WGS) has the potential to impact cancer diagnostics, prognostication, and therapy selection. This review emphasizes the requirements for implementing, validating, and maintaining a clinical WGS pipeline to obtain high-quality patient-specific data.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Genetics & Heredity
William R. Reay, Michael P. Geaghan, Joshua R. Atkins, Vaughan J. Carr, Melissa J. Green, Murray J. Cairns
Summary: This study proposes an approach that combines genetic risk with precision drug repurposing, linking genetic risk to biological processes related to drug targets. By integrating genomic association studies and expression data, this approach provides insights for drug repurposing in psychiatric and other complex disorders.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Health Care Sciences & Services
Rebecca Daly, Kate Hetherington, Emily Hazell, Bethany R. Wadling, Vanessa Tyrrell, Katherine M. Tucker, Glenn M. Marshall, David S. Ziegler, Loretta Lau, Toby N. Trahair, Tracey A. O'Brien, Kiri Collins, Andrew J. Gifford, Michelle Haber, Mark Pinese, David Malkin, Mark J. Cowley, Jonathan Karpelowsky, Donna Drew, Chris Jacobs, Claire E. Wakefield
Summary: Precision medicine programs aim to identify personalized treatments for children with cancer, but the various professional groups involved in delivering these programs are understudied. This study explored the experiences of professionals involved in Australia's first precision medicine trial for children with poor-prognosis cancer. The professionals expressed both complexity in their roles and positive views about the impact of precision medicine on their profession.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Surgery
Sarah B. Jochum, Mandakini Venkatramani, Ethan M. Ritz, Joanne Favuzza, Dana M. Hayden, Theodore J. Saclarides, Anuradha R. Bhama
Summary: Resident comfort with ICD increases with training, emphasizing the importance of formal evaluation and instruction for skill improvement. Attending surgeons are not universally comfortable with resident-led ICDs, especially for elective surgeries. Efforts for improving ICD education, such as direct observation and formal evaluation, may benefit residency programs.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
Theresia Pichler, Amy Rohrmoser, Anne Letsch, C. Benedikt Westphalen, Ulrich Keilholz, Volker Heinemann, Mario Lamping, Philipp J. Jost, Kristina Riedmann, Peter Herschbach, Ute Goerling
Summary: Patients undergoing molecular diagnostics in cancer treatment show limited understanding of the complex background and uncertainties regarding personal benefit. They also have unmet information needs and find the existential threat of waiting for results burdensome. Trust in physicians is emphasized as crucial for patients to withstand the strains of their situation.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Biochemistry & Molecular Biology
Fabio Pastorino, Mario Capasso, Chiara Brignole, Serena Giglio, Veronica Bensa, Sueva Cantalupo, Vito Alessandro Lasorsa, Annalisa Tondo, Rossella Mura, Angela Rita Sementa, Alberto Garaventa, Mirco Ponzoni, Loredana Amoroso
Summary: Neuroblastoma is the most common extracranial solid tumor in childhood. The prognosis for patients with metastatic relapse or refractory disease is poor. The integration of genome sequencing into standard clinical practice is necessary for personalized therapy. In this study, whole exome sequencing was performed on two patients with relapsed NB, and actionable genetic variations were identified and treated accordingly. The results demonstrate the feasibility of incorporating clinical WES into pediatric oncology practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Makenzie Beaman, Kimberley Fisher, Marie McDonald, Queenie K. G. Tan, David Jackson, Benjamin T. Cocanougher, Andrew P. Landstrom, Charlotte A. Hobbs, Michael Cotten, Jennifer L. Cohen
Summary: Rapid genome sequencing is crucial for providing targeted care to critically ill infants. A pilot study involving eight neonates showed a diagnostic rate of 37.5% using rapid whole genome sequencing alone, and 50% for the cohort overall. The diagnoses led to changes in management and identification of affected relatives. Challenges with sample collection were also discussed. The study also established a research protocol pipeline for cases where a diagnosis was not reached by rapid genome sequencing or other clinical testing. The benefits, limitations, challenges, and potential for incorporating rapid whole genome sequencing into routine clinical evaluation in the neonatal period were described.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Samantha O. Hasenleithner, Michael R. Speicher
Summary: The analysis of cell-free DNA from liquid biopsy, particularly circulating tumor DNA (ctDNA), has shown promise in oncology, but questions remain regarding its clinical validity and utility, necessitating further research and study.
Article
Clinical Neurology
Nicolas Hertzsprung, Kiril Krantchev, Thomas Picht, Anna L. L. Roethe, Kerstin Rubarth, Josch Fuellhase, Peter Vajkoczy, Gueliz Acker
Summary: This study aimed to investigate the usefulness of additional stereoscopic visualization of patient-specific imaging during informed consent conversation. The results showed that although there was no significant improvement in patients' objective understanding, patients perceived stereoscopic imaging as helpful and it potentially increased their confidence in treatment decisions.
ACTA NEUROCHIRURGICA
(2023)
Article
Genetics & Heredity
Saskia C. Sanderson, Celine Lewis, Melissa Hill, Michelle Peter, Meriel McEntagart, Daniel Gale, Huw Morris, Mariya Moosajee, Beverly Searle, Amy Hunter, Christine Patch, Lyn S. Chitty
Summary: This study assessed the decisions, attitudes, and understanding of participants undergoing genome sequencing for rare disease diagnosis. The majority of participants made informed decisions with low decisional conflict, and were motivated more by the desire to help others than obtaining a diagnosis for themselves. Concerns were mostly related to the potential psychological impact of the results. Both general and context-specific understanding of genome sequencing were moderately high.
GENETICS IN MEDICINE
(2022)
Article
Oncology
Marie-Kristin Tilch, Melanie Schranz, Alice Moringlane, Matthias Theobald, Georg Hess
Summary: Extensive informed consent procedures in clinical cancer trials have not been associated with higher satisfaction or measurable objective understanding, suggesting limited benefit.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Biochemistry & Molecular Biology
Philip Coffin, Aiwu He
Summary: Hepatocellular carcinoma (HCC) is a common malignancy with diverse risk factors such as viruses and alcohol. The heterogeneous nature of HCC has hindered the development of targeted therapies, and there is no consensus on the classification and treatment of HCC based on molecular subtypes. Recent breakthroughs in drug development have expanded treatment options but personalized targeted therapy for each patient with HCC remains challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nicole Mott, Ton Wang, Jacquelyn Miller, Nicholas L. Berlin, Sarah Hawley, Reshma Jagsi, Brian J. Zikmund-Fisher, Lesly A. Dossett
Summary: Studies have found that older women with breast cancer have maximizing-minimizing preferences, with some preferring more medical interventions and aggressive therapies. Despite de-implementation guidelines, up to 65% of older women continue to receive unnecessary treatments.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Haoyang Yan, Patricia J. Deldin, Stephanie K. Kukora, Cynthia Arslanian-Engoren, Kenneth Pituch, Brian J. Zikmund-Fisher
Summary: Parents' narratives about the long-term quality of life of their child and family can influence their tracheostomy decisions and forecasting, potentially leading to more accurate decision-making. Narrative-based interventions may be beneficial in situations where forecasting errors are common.
MEDICAL DECISION MAKING
(2021)
Article
Health Care Sciences & Services
Lyndal J. Trevena, Carissa Bonner, Yasmina Okan, Ellen Peters, Wolfgang Gaissmaier, Paul K. J. Han, Elissa Ozanne, Danielle Timmermans, Brian J. Zikmund-Fisher
Summary: This article focuses on presenting more complex, task-specific aspects of numeric information in patient decision aids. Strong evidence supports the use of independent event rates and incremental absolute risk differences for the effect size of test outcomes. Well-designed visual formats can help reduce bias and enhance comprehension.
MEDICAL DECISION MAKING
(2021)
Review
Health Care Sciences & Services
Carissa Bonner, Lyndal J. Trevena, Wolfgang Gaissmaier, Paul K. J. Han, Yasmina Okan, Elissa Ozanne, Ellen Peters, Danielle Timmermans, Brian J. Zikmund-Fisher
Summary: This article reviews the current evidence for how to present numerical probabilities within patient decision aids, presenting 5 fundamental issues and recommendations for unbiased comparisons between outcomes and interventions to meet the needs of varying numeracy. Understanding how different numerical formats can bias risk perception will help decision aid developers communicate risks in a balanced, comprehensible manner.
MEDICAL DECISION MAKING
(2021)
Article
Psychology, Applied
Jillian O'Rourke Stuart, Paul D. Windschitl, Jane E. Miller, Andrew R. Smith, Brian J. Zikmund-Fisher, Laura D. Scherer
Summary: Research suggests that people's responses to ambiguity in health treatment contexts are influenced by attributions. When ambiguity is attributed to factors beyond individual control, people tend to avoid or be indifferent towards it; however, when ambiguity is attributed to factors that individuals can control or to overly optimistic beliefs, people tend to seek ambiguity.
JOURNAL OF BEHAVIORAL DECISION MAKING
(2022)
Article
Surgery
Lesly A. Dossett, Nicole M. Mott, Brooke C. Bredbeck, Ton Wang, Chad Tc Jobin, Tasha M. Hughes, Sarah T. Hawley, Brian J. Zikmund-Fisher
Summary: The study found that individual maximizing-minimizing tendencies may influence women's treatment preferences when facing a hypothetical breast cancer diagnosis. Targeted messaging may facilitate avoidance of low-value breast cancer care.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Jessica S. Ancker, Natalie C. Benda, Mohit M. Sharma, Stephen B. Johnson, Stephanie Weiner, Brian J. Zikmund-Fisher
Summary: Many people struggle with interpreting and applying quantitative information to health decisions, leading to research on effective ways to communicate numbers. This article introduces three taxonomies to categorize terminology in the literature, addressing inconsistencies and contradictions.
Article
Immunology
Zhuoying Huang, Mengdi Ji, Jia Ren, Xiaodong Sun, Matthew L. Boulton, Brian J. Zikmund-Fisher, Abram L. Wagner
Summary: In China, HPV vaccines have low uptake and are not mandatory. A study was conducted to assess the impact of different messages about the HPV vaccine on willingness to accept it, taking into account parental sociodemographics and the age/gender of a child. The study found that messaging had some limited impact, with parents more likely to accept the vaccine for a daughter and an older child, and certain messages increasing willingness to vaccinate a son or daughter of a specific age.
Editorial Material
Health Care Sciences & Services
Brian J. Zikmund-Fisher
MEDICAL DECISION MAKING
(2022)
Article
Public, Environmental & Occupational Health
Terri Voepel-Lewis, Carol J. Boyd, Alan R. Tait, Sean Esteban McCabe, Brian J. Zikmund-Fisher
Summary: This study aimed to enhance parents' risk perceptions and disposal intentions regarding leftover prescription opioids through a new educational program and decrease their retention behavior. The intervention provided interactive feedback on risk and mitigation advice. The results showed that parents in the intervention group had increased risk perceptions of child misuse and keeping/sharing opioids, and the intervention reduced the likelihood of parents' opioid retention.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Medical Informatics
Haoyang Yan, Stephanie K. Kukora, Kenneth Pituch, Patricia J. Deldin, Cynthia Arslanian-Engoren, Brian J. Zikmund-Fisher
Summary: By interviewing parents with tracheostomy decision-making experience, we developed an intervention with peer parent narratives to help parents anticipate and prepare for future challenges. The user-centered design process allowed us to incorporate parental perspectives and tailor the intervention to meet their expectations.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Article
Oncology
Reshma Jagsi, Krithika Suresh, Chris D. Krenz, Rochelle D. Jones, Kent A. Griffith, Lydia Perry, Sarah T. Hawley, Brian Zikmund-Fisher, Kayte Spector-Bagdady, Jodyn Platt, Raymond De Vries, Angela R. Bradbury, Pranshu Bansal, Melissa Kaime, Monaliben Patel, Richard L. Schilsky, Robert S. Miller, Rebecca Spence
Summary: CancerLinQ aims to improve quality of care and advance research by using data sharing technology. Patient awareness and attitudes towards data sharing were evaluated in a survey, which highlighted the importance of engaging patients and respecting their perspectives.
JCO ONCOLOGY PRACTICE
(2023)
Editorial Material
Computer Science, Information Systems
Jessica S. Ancker, Natalie C. Benda, Brian J. Zikmund-Fisher
Summary: Data visualizations can effectively help people understand health-related data. However, the lack of clarity about communicators' goals has resulted in a lack of practical design guidance from high-quality studies comparing data visualizations. The authors propose new taxonomies of outcome measures and tasks that guide a large-scale systematic review of health numbers communication literature. Using these taxonomies allows designers to determine whether specific data presentation formats or features support or inhibit desired audience cognitions, feelings, or behaviors. Taking an outcomes-based approach is essential for deriving practical knowledge from information visualization research.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Hans S. Schroder, Andrew Devendorf, Brian J. Zikmund-Fisher
Summary: Depression is often seen as a disease or dysfunction, but this framing leads to negative consequences. This study suggests an alternative framework, viewing depression as an adaptive signal. The findings show that this alternative framing can reduce stigma, improve self-efficacy and promote adaptive beliefs about depression.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Health Care Sciences & Services
Marc S. Piper, Brian J. Zikmund-Fisher, Jennifer K. Maratt, Jacob Kurlander, Valbona Metko, Akbar K. Waljee, Sameer D. Saini
Summary: Despite high enthusiasm for repeat screening, patients were willing to delay their own colonoscopy for higher-risk peers, with greater trust in physician and greater health literacy being key factors.
MDM POLICY & PRACTICE
(2021)