Article
Cell Biology
Tomohiro Fukaya, Tomofumi Uto, Shuya Mitoma, Hideaki Takagi, Yotaro Nishikawa, Moe Tominaga, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato
Summary: Dysbiosis in the gut impairs the induction of oral tolerance generated in MesLNs. Antibiotic-driven gut dysbiosis causes dysfunction of CD11c+CD103+ conventional dendritic cells (cDCs) in MesLNs, leading to the failure of establishing oral tolerance. This breakdown is caused by the impaired crosstalk between CD11c+CD103+ cDCs and ILC3s due to antibiotic-induced dysbiosis.
Article
Immunology
Carolin Wiechers, Mangge Zou, Eric Galvez, Michael Beckstette, Maria Ebel, Till Strowig, Jochen Huehn, Joern Pezoldt
Summary: Research shows that the microbiota and their metabolites have a limited impact on the induction of pTreg in mLNs, and do not contribute to the initialization of the Treg-specific epigenetic landscape.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Yi Zhang, Lei Li, Genevieve Genest, Wei Zhao, Dan Ke, Sabrina Bartolucci, Nils Pavey, Tho-Alfakar Al-Aubodah, Duncan Lejtenyi, Bahar Torabi, Moshe Ben-Shoshan, Bruce Mazer, Ciriaco A. Piccirillo
Summary: In this study, the induction of specific T-REG cells during oral immunotherapy (OIT) in children with cow's milk protein (CMP) allergy was found to be effective in promoting tolerance and reducing Th2 responses. The expansion of these T-REG cells correlated with successful desensitization to CMP and may be a potential marker for predicting the time to reach maintenance phase in OIT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Yue Cai, Yanqin Zhao, Yongbo Kang, Ying Yang
Summary: Allergic diseases have become an important public health issue in moderately prosperous societies. The colonization of microorganisms in early life plays a significant role in the development of the immune system and allergies. The oral microbiota, as the first point of contact between foreign antigens and the immune system, may have a key role in the development of allergies. However, research on the effects of oral microorganisms on allergies and asthma is limited and needs further investigation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Jian Tan, Jemma Taitz, Shir Ming Sun, Lachlan Langford, Duan Ni, Laurence Macia
Summary: Modern industrial practices have changed the human diet, leading to increased consumption of processed foods and increased risk of inflammatory disorders. Dietary factors can directly regulate the development of anti-inflammatory regulatory T cells (Treg) and indirectly modulate Treg differentiation by altering the composition of gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Javier Sanchez-Solares, Luis Sanchez, Carmela Pablo-Torres, Celso Diaz-Fernandez, Poul Sorensen, Domingo Barber, Cristina Gomez-Casado
Summary: The study found that CD patients have significantly decreased expression of epithelial junction proteins in their oral mucosa, suggesting compromised barrier integrity. The increase in FoxP3+ cells in CD patients indicates recruitment of Tregs to the damaged mucosa. Amphiregulin mRNA levels in PBMCs and epithelial damage in the oral mucosa correlated with Treg infiltration, suggesting a potential repair phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Richard I. Walker, A. Louis Bourgeois
Summary: Oral immunization is an effective strategy against mucosal enteric pathogens. Inactivated whole bacterial cells can also induce protective immunity. Developing a safe and simple delivery format with controlled immunogenic amounts of complex antigens is essential. Enhancing the efficacy of whole cell vaccines can be achieved through genetic engineering and the use of mucosal adjuvants. The development of ETVAX, a vaccine candidate against enterotoxigenic Escherichia coli (ETEC), has shown promising results.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Lachlan M. Moldenhauer, Min Jin, Jasmine J. Wilson, Ella S. Green, David J. Sharkey, Mark D. Salkeld, Thomas C. Bristow, M. Louise Hull, Gustaaf A. Dekker, Sarah A. Robertson
Summary: Research has shown that oral contraception use can impact the number and phenotype of Treg cells, leading to physiological changes and altered disease susceptibility.
Article
Immunology
Sara Anvari, Levi Watkin, Kimal Rajapakshe, Oluwatomi Hassan, Kimberly Schuster, Cristian Coarfa, Carla M. Davis
Summary: In peanut allergic patients undergoing POIT, there are specific expression profiles of peripheral naive and mature gdTreg cells that gradually return to a healthy state, indicating that gdTreg cells may contribute to the tolerogenic effect of POIT within the first 24 weeks of treatment.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Jinzhi Wang, Shuang Zheng, Xin Yang, Ben Huazeng, Qian Cheng
Summary: This study demonstrates the impact of microbial dysbiosis associated with non-IgE-mediated cow's milk-induced proctocolitis on intestinal Treg cells and immune homeostasis, leading to an overactivated Th2 biased immune response. Specific gut microbial phylotypes potentially responsible for this disruption have been identified.
MICROBIAL PATHOGENESIS
(2021)
Review
Immunology
Yanbei Lu, Zhengyi Li, Xian Peng
Summary: Over the past decade, the connection between oral health, intestinal microbiota, and systemic diseases has been further confirmed. Certain oral microbial species have been found in pathological intestines or feces, serving as biomarkers for intestinal diseases. Even in healthy individuals, a small portion of the oral microbiome can pass through or colonize the lower gastrointestinal tract. When the anatomical barrier is disrupted, opportunistic pathogens from the oral cavity can expand and contribute to the development of intestinal diseases. These disruptors interact with the intestinal microbiota, leading to disturbance of indigenous microorganisms and mucosal barriers through colonization, circulation, or metabolite pathways. Through interaction with the immune system, oral-derived pathogens induce inflammation responses and shift the microenvironment in the intestine towards a pre-disease state. Therefore, the oral-gut microbiome axis provides new insights into clinical therapy options, and a balanced gut ecology requires simultaneous consideration of both oral and gut microbiomes. This review summarizes the possible routes of oral microbes entering the intestine and the effects of specific oral bacteria on intestinal microbiota and the host's immune responses.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Allergy
Daniel Lozano-Ojalvo, Scott R. Tyler, Carlos J. Aranda, Julie Wang, Scott Sicherer, Hugh A. Sampson, Robert A. Wood, A. Wesley Burks, Stacie M. Jones, Donald Y. M. Leung, Maria Curotto de Lafaille, M. Cecilia Berin
Summary: This study observed that oral immunotherapy can increase the frequency of Tregs in individuals with lasting clinical tolerance. It also found that the release of IL-2 from Th2 effector cells can induce delayed and persistent activation of Tregs, which could be significant for improving current oral immunotherapy approaches.
Article
Microbiology
Olivia Briceno, Mauricio Gonzalez-Navarro, Nadia Montufar, Monserrat Chavez-Torres, Indira Abato, Ariana Espinosa-Sosa, Yuria Ablanedo-Terrazas, Yara Luna-Villalobos, Santiago Avila-Rios, Gustavo Reyes-Teran, Sandra Pinto-Cardoso
Summary: This study characterized immune cell populations and bacterial microbiota in adenoids, tonsils, and the oral cavity of PLWH and HIV-seronegative individuals. Differences in activated T cells, T helper cell populations, and discriminant genera were observed between PLWH and SN, while alpha diversity was comparable. HIV infection had a minor impact on bacterial community structure at each site.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Amrita Bhattacharjee, Ansen H. P. Burr, Abigail E. Overacre-Delgoffe, Justin T. Tometich, Deyi Yang, Brydie R. Huckestein, Jonathan L. Linehan, Sean P. Spencer, Jason A. Hall, Oliver J. Harrison, Denise Morais da Fonseca, Elizabeth B. Norton, Yasmine Belkaid, Timothy W. Hand
Summary: Environmental enteric dysfunction (EED) is a gastrointestinal inflammatory disease caused by malnutrition and chronic infection, leading to stunting in children and reduced efficacy of oral vaccines. Research has shown that ROR gamma T(+)FOXP3(+) regulatory T cells play a crucial role in regulating intestinal immunity, affecting the effectiveness of oral vaccines.
Article
Immunology
Linglin Fu, Wanglei Lin, Chong Wang, Yanbo Wang
Summary: In this study, a 3-dimensional intestinal cell model was established to mimic the intestinal mucosal immune system, showing more significant and specific allergic responses compared to conventional cell models and mouse models. This model is of great importance for food allergy investigations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Toshiaki Shimizu, Yoshiko Nakayama, Eizaburo Ishii, Shinobu Ida, Tomoki Satou, Daisuke Tokuhara, Katsuhiro Arai, Masahiro Nii, Hans Rydholm, Toshitaka Yajima, Hiroshi Odajima, Ryoji Kobayashi, Tadashi Sato, Tsuyoshi Sogo, Takashi Ishige, Reiko Hatori, Seiichi Kagimoto, Hisashi Kawashima, Takahiro Kudo, Hideki Kumagai, Hitoshi Tajiri
PEDIATRICS INTERNATIONAL
(2019)
Article
Endocrinology & Metabolism
Chikahiko Numakura, Gen Tamiya, Masao Ueki, Tomoo Okada, Shun-ichi Maisawa, Kanako Kojima-Ishii, Jun Murakami, Reiko Horikawa, Daisuke Tokuhara, Koichi Ito, Masanori Adachi, Takahiro Abiko, Tetsuo Mitsui, Kiyoshi Hayasaka
JOURNAL OF INHERITED METABOLIC DISEASE
(2019)
Article
Pediatrics
Chantel T. Y. Ng, Yoshiharu Isoura, Yuki Cho, Daisuke Tokuhara
PEDIATRICS INTERNATIONAL
(2019)
Article
Immunology
Norikatsu Hikita, Yuki Cho, Daisuke Tachibana, Takashi Hamazaki, Masayasu Koyama, Daisuke Tokuhara
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2019)
Article
Gastroenterology & Hepatology
Masanao Nakamura, Kenji Watanabe, Naoki Ohmiya, Fumihito Hirai, Teppei Omori, Daisuke Tokuhara, Konosuke Nakaji, Sadaharu Nouda, Motohiro Esaki, Yukinori Sameshima, Hidemi Goto, Akira Terano, Hisao Tajiri, Toshiyuki Matsui
Summary: The study aimed to evaluate the effectiveness of the PillCam patency capsule in preventing small bowel capsule endoscopy retention, and found that it helped preclude retention in most patients, but accurate localization was essential in cases without excretion.
DIGESTIVE ENDOSCOPY
(2021)
Review
Gastroenterology & Hepatology
Darrick K. Li, Muhammad Rehan Khan, Zhen Wang, Voranush Chongsrisawat, Panida Swangsak, Ulrike Teufel-Schaefer, Guido Engelmann, Imeke Goldschmidt, Ulrich Baumann, Daisuke Tokuhara, Yuki Cho, Marion Rowland, Anders B. Mjelle, Grant A. Ramm, Peter J. Lewindon, Peter Witters, David Cassiman, Ioana M. Ciuca, Larry D. Prokop, Samir Haffar, Kathleen E. Corey, M. H. Murad, Katryn N. Furuya, Fateh Bazerbachi
LIVER INTERNATIONAL
(2020)
Article
Endocrinology & Metabolism
Yoshiharu Isoura, Yuki Cho, Hiroki Fujimoto, Takashi Hamazaki, Daisuke Tokuhara
OBESITY RESEARCH & CLINICAL PRACTICE
(2020)
Article
Gastroenterology & Hepatology
Yuki Cho, Daijiro Kabata, Eiji Ehara, Akira Yamamoto, Tatsuki Mizuochi, Sotaro Mushiake, Hironori Kusano, Yuko Kuwae, Tsugutoshi Suzuki, Sawako Uchida-Kobayashi, Hiroyasu Morikawa, Yuga Amano-Teranishi, Kiyohide Kioka, Atsushi Jogo, Yoshiharu Isoura, Takashi Hamazaki, Yosuke Murakami, Daisuke Tokuhara
Summary: Fontan patients are prone to developing both portal and sinusoidal fibrosis. Liver stiffness could be influenced by HVPG, and using the conventional cut-off values for LS overestimates and overtreats liver fibrosis in these patients.
HEPATOLOGY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yoshiyuki Okano, Miki Okamoto, Masahide Yazaki, Ayano Inui, Toshihiro Ohura, Kei Murayama, Yoriko Watanabe, Daisuke Tokuhara, Yasuhiro Takeshima
Summary: Patients with citrin deficiency show diverse clinical features during the adaptation/compensation period and have a characteristic high protein, high fat, low carbohydrate diet. Recent studies suggest that a diet intervention may help prevent the onset of type II citrullinemia in these patients. Analysis shows that patients have higher energy intake compared to the standard, with a PFC ratio indicating higher protein and fat intake but lower carbohydrate consumption. Differences in PFC ratio between male and female patients may contribute to the lower frequency of CTLN2 in females. Despite higher energy intake, particularly from a low carbohydrate diet, patients were generally not overweight and may benefit from dietary intervention to achieve normal growth and prevent CTLN2 onset.
MOLECULAR GENETICS AND METABOLISM
(2021)
Review
Immunology
Daisuke Tokuhara, Norikatsu Hikita
Summary: Neonates and infants are more susceptible to infections with severe outcomes. The weak vaccine-induced immunity in infants may be due to their immature innate immune response. Developing vaccines for these children requires an understanding of their uniquely immature innate immunity.
Article
Medicine, General & Internal
Shoko Sakamoto, Dai Miyawaki, Ayako Goto, Yuji Harima, Daisuke Tokuhara, Koki Inoue
Summary: The COVID-19 pandemic has a profound impact on mental health, with children with undiagnosed ASD at risk of developing anxiety disorders due to the pandemic. Interventions for ASD may be more appropriate in these cases than starting treatment for anxiety disorders as the first-line option.
Editorial Material
Pediatrics
Yuki Cho, Daisuke Tokuhara
PEDIATRICS INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Miki Okamoto, Yoshiyuki Okano, Mai Okano, Masahide Yazaki, Ayano Inui, Toshihiro Ohura, Kei Murayama, Yoriko Watanabe, Daisuke Tokuhara, Yasuhiro Takeshima
Summary: Patients with citrin deficiency have a preference for high protein, high fat, and low carbohydrate diet, and tend to dislike foods with low protein, low fat, and high carbohydrate content. Carbohydrates have the strongest influence on patients' food preference, and female patients show a stronger aversion to high carbohydrate foods than males. The preferred protein, fat, and carbohydrate energy ratio of patients' favorite foods aligns closely with their daily diet, suggesting a strive for nutritional balance from early infancy to compensate for the metabolic dissonance caused by citrin deficiency.
Review
Nutrition & Dietetics
Daisuke Tokuhara
Summary: NAFLD is the most common chronic liver disease in children and adolescents, with obesity being the leading cause, although its etiologies are multifactorial. Dysbiosis of the gut microbiota plays a key role in promoting the development of NAFLD, disrupting gut-liver homeostasis. Conventional approaches and new strategies have shown potential in restoring dysbiosis and could be effective in preventing and treating NAFLD.
FRONTIERS IN NUTRITION
(2021)
Article
Multidisciplinary Sciences
Mariko Kamioka, Yoshiyuki Goto, Kiminori Nakamura, Yuki Yokoi, Rina Sugimoto, Shuya Ohira, Yosuke Kurashima, Shingo Umemoto, Shintaro Sato, Jun Kunisawa, Yu Takahashi, Steven E. Domino, Jean-Christophe Renauld, Susumu Nakae, Yoichiro Iwakura, Peter B. Ernst, Tokiyoshi Ayabe, Hiroshi Kiyono
Summary: Paneth cells in mice can be differentiated into two subtypes based on their production and utilization of fucosyltransferase 2 (Fut2). Fut2(+) Paneth cells are involved in host defense by creating niches for commensal bacteria and preventing invasion of pathogens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)