Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Aranjit Singh Randhawa, Norhayati Mohd Noor, Mohd Khairi Md Daud, Baharudin Abdullah
Summary: Bilastine is an effective and safe treatment for allergic rhinitis, showing comparable efficacy and safety with other oral antihistamines, with less incidence of somnolence compared to cetirizine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Lukas Israel, Gabriele Rotter, Ulrike Foerster-Ruhrmann, Josef Hummelsberger, Rainer Noegel, Andreas Michalsen, Tatjana Tissen-Diabate, Sylvia Binting, Thomas Reinhold, Miriam Ortiz, Benno Brinkhaus
Summary: Self-administered acupressure as a self-care technique shows potential benefits for patients with seasonal allergic rhinitis, improving disease-specific quality of life and reducing disease-related symptoms and medication intake. High-quality confirmatory studies are needed for further validation of these findings, including a sham-control group.
Article
Otorhinolaryngology
Orhan Kemal Kahveci, Selcuk Kuzu, Mustafa Altintas, Ayhan Vurmaz, Sefa Celik
Summary: The study showed that in allergic rhinitis patients, simultaneous use of nasal steroids and antihistamines significantly decreased total oxidative stress. Additionally, it was found that women and patients with seasonal allergic rhinitis had lower TOS levels compared to men and those with perennial allergic rhinitis.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)
Article
Allergy
Anne K. Ellis, Lori Connors, Marie-Josee Francoeur, Douglas P. Mack
Summary: Sublingual immunotherapy tablets (SLIT-T) are effective for allergic rhinitis, but some patients may experience local allergic reactions (LAR). Rupatadine has shown to be effective in treating or mitigating SLIT-T-related LAR. In cases where other antihistamines failed to prevent LAR, rupatadine allowed patients to continue SLIT-T treatment with minimal or no adverse reactions.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Article
Biology
Mohamed A. Morsy, Snehal S. Patel, Anita Bakrania, Mahmoud Kandeel, Anroop B. Nair, Jigar N. Shah, Sabah H. Akrawi, Mahmoud El-Daly
Summary: The study found that catechin alone or in combination with cetirizine can effectively inhibit allergic rhinitis, and the combination therapy is more effective. Catechin exerts its anti-allergic effect by inhibiting histamine release and reducing histidine decarboxylase activity.
Review
Otorhinolaryngology
Wirach Chitsuthipakorn, Minh P. Hoang, Dichapong Kanjanawasee, Kachorn Seresirikachorn, Kornkiat Snidvongs
Summary: Combination therapy with antihistamines and intranasal corticosteroids can improve symptoms and quality of life in patients with allergic rhinitis. Adding a decongestant, saline, or leukotriene receptor antagonist to antihistamine monotherapy can improve outcomes. Adding intranasal antihistamines can improve nasal symptoms, leukotriene receptor antagonists can improve ocular symptoms, and saline irrigation can improve quality of life when intranasal corticosteroid monotherapy is ineffective.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Medicine, General & Internal
Velia Malizia, Giuliana Ferrante, Giovanna Cilluffo, Rosalia Gagliardo, Massimo Landi, Laura Montalbano, Salvatore Fasola, Mirella Profita, Amelia Licari, Gian Luigi Marseglia, Stefania La Grutta
Summary: This study identified three endotypes in children with seasonal allergic rhinitis (SAR) based on cytokine evaluation. The study also found differences in nasal pH, nasal nitric oxide, and neutrophil percentage among the different endotypes.
FRONTIERS IN MEDICINE
(2022)
Article
Otorhinolaryngology
Haotao Zeng, Jiangqi Liu, Lihua Mo, Minyao Li, Aifa Tang, Xianhai Zeng, Miao Zhao, Pingchang Yang
Summary: In this study, nasal secretions of allergic rhinitis patients were analyzed, and 15 differentially expressed proteins (DEPs) were identified. These DEPs were significantly correlated with the total nasal symptom scores of patients with allergic rhinitis.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Immunology
Yuan Wang, Xuan Li, Shuntong Gu, Junhong Fu
Summary: This study found differences in the composition and function of the conjunctival and nasal microbiome in patients with allergic rhinoconjunctivitis (ARC) or allergic rhinitis (AR), suggesting a relationship between allergic conditions and the local microbiome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rui Tang, Shubin Lei, Liping Zhu, Yuzhen Lv, Hong Li
Summary: This study aimed to evaluate the preventative efficacy of omalizumab for seasonal allergic rhinoconjunctivitis (SARC) and explore its influencing factors. The retrospective analysis of patients' medical records found that pre-seasonal omalizumab treatment could significantly alleviate SARC-related symptoms and reduce medication use. The dosage and number of injections of omalizumab did not affect the preventative efficacy, with a single dose of 150mg achieving satisfactory outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper-Emil T. Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Buegel, Orestes A. Carpaij, Erick Forno, Andreanne Morin, Anders U. Eliasen, Yale Jiang, Maarten Van den Berge, Martijn C. Nawijn, Yang Li, Wei Chen, Louis J. Bont, Klaus Bonnelykke, Juan C. Celedon, Gerard H. Koppelman, Cheng-Jian Xu
Summary: The study demonstrates that nasal DNA methylation is the most accurate predictor for diagnosing childhood allergic diseases, identifying multimorbidity and IgE sensitization, with findings replicated in children of different ages and ethnicities.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Jordi Roca-Ferrer, Maria Perez-Gonzalez, Isam Alobid, Valeria Tubita, Mireya Fuentes, Marina Bantula, Rosa Munoz-Cano, Antonio Valero, Inaki Izquierdo, Joaquim Mullol, Jacopo Galli
Summary: This study aimed to assess the role of the Platelet-Activating Factor (PAF)/receptor (PAFR) system in chronic rhinosinusitis with nasal polyps (CRSwNP). The study found that PAFR protein was expressed in nasal mucosa and nasal polyps, and Lyso-PAF concentrations were higher in nasal polyps of asthmatic patients. These findings suggest that the PAF/PAFR system may play a role in CRSwNP pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Jie Guo, Shuai Xu
Summary: The study discovered that Astragaloside IV can inhibit the overproduction of inflammatory cytokines and MUC5AC in nasal epithelial cells under histamine stimulation, partly through the regulation of inflammation-related genes.
Article
Biochemistry & Molecular Biology
Jian-Bo Shao, Xiang-Qian Luo, Li-Hua Mo, Gui Yang, Zhi-Qiang Liu, Jiang-Qi Liu, Zhi-Gang Liu, Da-Bo Liu, Ping-Chang Yang
Summary: In this study, high Ras activation was detected in eosinophils isolated from nasal mucosal tissues of allergic rhinitis patients, associated with apoptosis resistance. The expression of Twist protein in allergic rhinitis eosinophils was positively correlated with Ras activation. Sensitization to IgG induced Twist expression and conferred eosinophils apoptosis resistance through Ras activation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)