期刊
MEDICAL SCIENCE MONITOR
卷 24, 期 -, 页码 7271-7278出版社
INT SCIENTIFIC LITERATURE, INC
DOI: 10.12659/MSM.910990
关键词
MicroRNAs; Radiography, Abdominal; Uterine Cervical Neoplasms
资金
- Jiangsu Provincial Medical Youth Talent [QNRC2016509]
- Taizhou City High-level Talent Research Project [27]
- Taizhou City Science and Technology Project [TS024]
Background: Radioresistance during radiotherapy of cervical cancer often leads to treatment failure; therefore, there is an urgent need to develop effective predictive indicators of radiosensitivity for cervical cancer patients. Material/Methods: Cervical cancer cells were collected from 40 patients who received surgical resections. The relationships be- tween apparent diffusion coefficient (ADC) values of masses before surgery and different micro-RNAs (miRNA) levels (miR-18a, miR-132, and miR-145) of these cells were investigated. Cervical cancer cells were divided into 4 groups according to the ADC values of original tumor tissues and expression level of miR-18a. Then, these cells were exposed with irradiation both in vitro and in vivo. Results: Advanced cervical cancer showed lower ADC values in magnetic resonance imaging. miR-18a, miR-132, and miR-145 all were increased in the cervical cancer tissues, while miR-18a showed a more marked negative correlation with ADC values. The results of in vitro and in vivo assays showed that higher expression of miR-18a in cervical cancer cells leads to more radiosensitivity, especially in cells from cancer tissues with lower ADC values. Conclusions: The combination of ADC values with expression level of miR-18a may be a new and reliable predictor for radiosensitivity of cervical cancer, helping cervical cancer patients with low ADC values and high expressions of miR-18a to achieve better outcomes in radiotherapy.
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