Article
Oncology
Deshuai Ren, Xiaoyu Zhuang, Yanxin Lv, Yun Zhang, Jiazhi Xu, Fengquan Gao, Dagang Chen, Yu Wang
Summary: This study found that FAM84B is highly expressed in glioma tissues and inhibits the proliferation of glioma cells through regulating the cell cycle pathways.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Fang Cao, Xiangping Xia, Yinchun Fan, Qian Liu, Jiancheng Song, Qiang Zhang, Yu Guo, Shengtao Yao
Summary: The study revealed a correlation between the expression level of PLK2 and the malignancy of gliomas, with high expression associated with poor prognosis. RNF180 may influence glioma cell apoptosis by regulating the ubiquitination of PLK2. Knocking down of PLK2 may suppress glioma development through inhibition of cell proliferation and promotion of cell apoptosis.
Article
Oncology
Defne Bayik, Cynthia F. Bartels, Katreya Lovrenert, Dionysios C. Watson, Duo Zhang, Kristen Kay, Juyeun Lee, Adam Lauko, Sadie Johnson, Alice Lo, Daniel J. Silver, Mary McGraw, Matthew Grabowski, Alireza M. Mohammadi, Filippo Veglia, Yi Fan, Michael A. Vogelbaum, Peter Scacheri, Justin D. Lathia
Summary: The study revealed that the enhanced cell adhesion ability of mMDSC in the GBM microenvironment is linked to tumor promotion, and targeting Integrin (31) and DPP-4 to interfere with mMDSC may be an effective way to alleviate immune suppression driven by myeloid cells in GBM.
Article
Oncology
Zigui Chen, Xin Yan, Changfeng Miao, Longyang Liu, Su Liu, Ying Xia, Weiyi Fang, Dandan Zheng, Qisheng Luo
Summary: This study provides evidence that MYH9 plays an important role in glioma by promoting cell proliferation and temozolomide resistance. Mechanistically, MYH9 inhibits the ubiquitination and degradation of NAP1L1, leading to activation of c-Myc and increased expression of CCND1/CDK4, which contributes to temozolomide resistance and proliferation in glioma cells. Additionally, upregulation of MYH9 is associated with poor prognosis in glioma patients. Targeting MYH9 could be a potential therapeutic strategy for glioma treatment in the future.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Jiaoyun Lv, Suhua Chen, Xin Chen, Jiawei Xie, Ziyi He, Tianrui Fan, Kaiming Ma, Kayisaier Abudurousuli, Jun Yang, Xiaoyan Qiu, Hui Dai
Summary: In glioma, high levels of IgG transcription are associated with poor prognosis, and glioma-derived IgG promotes cell proliferation and migration through the HGF/SF-Met or FAK/Src pathway.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Cell Biology
Hong-Qing Cai, Min-Jie Zhang, Zhi-Jian Cheng, Jing Yu, Qing Yuan, Jin Zhang, Yan Cai, Li-Yan Yang, Yu Zhang, Jia-Jie Hao, Ming-Rong Wang, Jing-Hai Wan
Summary: FKBP10 is highly expressed in glioma and promotes cell proliferation by interacting with Hsp47 and activating the AKT-CREB-PCNA signaling pathways. Inhibition of FKBP10 related signaling may offer a potential therapeutic option for glioma patients.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Yunsheng Liu, Xiangping Xu, Han Tang, Yuchen Pan, Bing Hu, Guodong Huang
Summary: The study found that RA, as a Fyn inhibitor, has anti-tumor effects in U251 and U343 glioma cells, significantly suppressing cell proliferation, migration, and invasion, and inducing apoptosis. Additionally, RA exerts its cytotoxicity by modulating the PI3K/Akt/NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Sabbir Khan, Rajasekaran Mahalingam, Shayak Sen, Emmanuel Martinez-Ledesma, Arshad Khan, Kaitlin Gandy, Frederick F. Lang, Erik P. Sulman, Kristin D. Alfaro-Munoz, Nazanin K. Majd, Veerakumar Balasubramaniyan, John F. de Groot
Summary: Interferon signaling plays a crucial role in glioma tumorigenesis, with high IFN/STAT1 signaling associated with poor survival outcomes and mesenchymal phenotype in patients. Targeting IFN signaling may be beneficial for a specific subgroup of GBM patients, with IFN-beta showing promise as a potential adjuvant therapy.
Article
Cell Biology
Feng Wang, Ma-ChiCheng Bao, Jing Xu, Lan-Lan Shi, Rui-Ze Niu, Ting-Hua Wang, Jia Liu
Summary: The study aimed to investigate the effect of Scutellarin on glioma by downregulating BIRC5. The results showed that the expression of BIRC5 in glioma tissues was significantly higher than that in normal brain tissues. Scutellarin significantly reduced tumor growth and improved animal survival. It also downregulated the expression of BIRC5 in U251 cells, leading to increased apoptosis and inhibited cell proliferation. These findings suggest that Scutellarin promotes apoptosis and inhibits proliferation of glioma cells by downregulating BIRC5 expression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Zheng Zhu, Jiao Wang, Juan Tan, Yue-Liang Yao, Zhi-Cheng He, Xiao-Qing Xie, Ze-Xuan Yan, Wen-Juan Fu, Qing Liu, Yan-Xia Wang, Tao Luo, Xiu-Wu Bian
Summary: The study revealed that high expression of CAPS in glioma is associated with poor survival. CAPS promotes glioma proliferation by regulating the cell cycle and interacts with MYPT1 to affect PLK1 phosphorylation. The PLK1 inhibitor volasertib enhances the therapeutic effect of temozolomide in glioma.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hongyu Wang, Ruiqin Han, Qiao Li, Wei Kang, Qiang Dong, Hang Yin, Liang Niu, Junqiang Dai, Yunji Yan, Yuanping Su, Xuan Yao, He Zhang, Guoqiang Yuan, Yawen Pan
Summary: In this study, we found that EEF1E1 plays a crucial role in regulating the cell cycle and cell proliferation in glioma cells. It downregulates the expression of PTEN and modulates downstream cell cycle-related proteins through the PTEN/AKT signaling pathway. Our findings demonstrate that EEF1E1 knockdown effectively inhibits glioma cell proliferation, suggesting that EEF1E1 could serve as a potential therapeutic target for glioma treatment with significant clinical implications.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Shikai Gui, Peng Chen, Yu Liu, Qiaorong Chen, Tianxiang Cheng, Shulong Lv, Tong Zhou, Zhen Song, Juexian Xiao, Wei He, Shengtao Yuan, Zujue Cheng
Summary: This study identified that high TUBA1C expression correlates with poor outcomes in glioma patients, and knocking down TUBA1C can suppress glioma cell proliferation via cell cycle arrest, potentially serving as a therapeutic biomarker.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Shreyasi Mukherjee, David M. Luedeke, Leslie McCoy, Makiko Iwafuchi, Aaron M. Zorn
Summary: In this study, the researchers use time-resolved multi-omic analyses to investigate the mechanism of lineage-specific WNT-responsive transcription guided by SOX transcription factors during the differentiation of human pluripotent stem cells. They find that SOX17 and SOX2 play important roles in recruiting B-catenin to lineage-specific WNT-responsive enhancers, some of which are not occupied by TCFs. By establishing a permissive chromatin landscape and recruiting a WNT-enhanceosome complex, SOX transcription factors activate SOX/B-catenin-dependent transcription. These findings have broad mechanistic implications for understanding the specificity of WNT responses across developmental and disease contexts.
Article
Oncology
Fubin Li, Lin Wu, Bin Liu, Xiangyang An, Xinrui Du
Summary: Recent studies have revealed the critical role of circRNAs in glioma occurrence and progression, but many circRNAs with unknown functions require further exploration. This study investigated circTIE1 expression in glioma tissues and cell lines and demonstrated its involvement in glioma cell viability, proliferation, migration, and aggression. Mechanistically, circTIE1 was found to upregulate TEAD1 expression by sponging miR-1286, a known functional gene in glioma advancement. The identification of circTIE1 suggests its potential as a crucial marker for glioma progression and diagnosis and a target for molecular targeted therapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Timucin Avsar, Tansu Bilge Kose, Muhammed Deniz Oksal, Gizem Turan, Turker Kilic
Summary: This study investigated the effect of IDH1 gene mutation on glioma cells and found that IDH1 mutation can promote cell proliferation, invasion and migration through upregulation of the mTOR signaling pathway.
MOLECULAR BIOLOGY REPORTS
(2022)