Article
Biochemistry & Molecular Biology
Ana Martinez-Vacas, Johnny Di Pierdomenico, Alejandro Gallego-Ortega, Francisco J. Valiente-Soriano, Manuel Vidal-Sanz, Serge Picaud, Maria Paz Villegas-Perez, Diego Garcia-Ayuso
Summary: The aim of this study was to investigate the neuroprotective effects of taurine administration in dystrophic rats with retinal degeneration. The results showed that taurine treatment increased taurine plasma levels and photoreceptor survival, improved retinal function, reduced inflammation and oxidative stress, and enhanced retinal pigment epithelium function. These findings indicate that taurine has potential neuroprotective effects in retinal degeneration.
Article
Engineering, Biomedical
Yana G. Toropova, Irina A. Zelinskaya, Mariya N. Gorshkova, Daria S. Motorina, Dmitriy Korolev, Fedor S. Velikonivtsev, Kamil G. Gareev
Summary: The study investigated the biocompatibility and arterial effects of albumin-covered IONP under changing blood flow conditions. Results showed that albumin-covered IONP performed well in maintaining vasodilation function, indicating its potential use as a vascular-safe vehicle for further research.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Shih-Fang Wu, Chih-Yao Lin, Rong-Kung Tsai, Yao-Tseng Wen, Feng-Huei Lin, Chia-Yu Chang, Ching- Shen, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Chin-San Liu, Yan-Ting Chen, Hong-Lin Su
Summary: Research found that mitochondrial transplantation can moderately attenuate the degeneration of retinal layers in RCS rats. This result was confirmed through histological examination and OCT measurement of retina thickness. VEP analysis showed that the transmission time of electrical signals after mitochondrial transplantation was similar to the normal value. The results suggest that mitochondrial transplantation can improve the degeneration of photoreceptors in RCS rats and have potential for clinical application.
Article
Biochemistry & Molecular Biology
Celine Koster, Koen T. van den Hurk, Jacoline B. ten Brink, Colby F. Lewallen, Boris Stanzel, Kapil Bharti, Arthur A. Bergen
Summary: The lack of suitable animal models for (dry) age-related macular degeneration (AMD) has hindered therapeutic research into the disease. In this study, pigmented rats and mice were systematically injected with various doses of sodium iodate (SI) to evaluate their suitability as models for studying experimental therapies for retinal degenerative diseases. The results showed dose-dependent structural and functional pathological effects on the retinal pigment epithelium (RPE) and retina, with a dose of 30 mg/kg appearing to be suitable for future studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mohamed F. Dora, Nabil M. Taha, Mohamed A. Lebda, Aml E. Hashem, Mohamed S. Elfeky, Yasser S. El-Sayed, Soad Al Jaouni, Ali H. El-Far
Summary: The study revealed that IONPs induced oxidative damage in the brains of rats, while quercetin supplementation could effectively protect the brain from oxidative injuries in a dose-dependent manner. It is recommended to supplement quercetin during IONP therapy to reduce potential health hazards.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Elena Daniele, Lorenzo Bosio, Noor Ahmed Hussain, Barbara Ferrari, Stefano Ferrari, Vanessa Barbaro, Brian McArdle, Nicolo Rassu, Marco Mura, Francesco Parmeggiani, Diego Ponzin
Summary: Recent clinical studies indicate the potential of retinal pigment epithelial (RPE) cell replacement therapy in preserving vision in retinal degenerative diseases. This study aimed to investigate the survival and behavior of human embryonic stem cell-derived RPE (hESC-RPE) cells on a decellularized Descemet's Membrane (DM), which could be a suitable substrate for retinal cell therapy.
Article
Pharmacology & Pharmacy
Michal Kluknavsky, Andrea Micurova, Martin Skratek, Peter Balis, Monika Okuliarova, Jan Manka, Iveta Bernatova
Summary: This study investigated the differences in biodistribution of superparamagnetic magnetite nanoparticles (IONs) in the heart and liver of normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. It also examined the effects of IONs on the expression of selected genes involved in iron metabolism regulation. The results showed that SHR had less ION incorporation in tissues compared to WKY, and hearts had less ION distribution compared to livers.
Article
Biochemistry & Molecular Biology
Andrea Micurova, Michal Kluknavsky, Silvia Liskova, Peter Balis, Martin Skratek, Ludmila Okruhlicova, Jan Manka, Iveta Bernatova
Summary: The study investigated the effects of Fe3O4@PEG nanoparticles in hypertensive rats, noting alterations in blood pressure, nitric oxide synthase activity, and gene expression in the aorta and liver. Results suggest that caution should be taken when using iron oxide nanoparticles in hypertensive subjects due to potential differences in tissue distribution and biological effects.
Article
Chemistry, Multidisciplinary
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: Magnetization is a measurable property of materials that provides information about their electronic structure, phase purity, and impurities. Superparamagnetism, a size-dependent property of magnetic materials, has been underexplored in the field of quantum materials. In this study, a statistical model is used to analyze a dataset of variable-size superparamagnetic Fe3O4 particles. The results show that parameters of the intrinsic probability distribution, such as the maximum susceptibility, are more suitable for describing the superparamagnetic behavior compared to standard measures like saturation magnetization. This analysis has potential applications in synthesis diagnostics and prediction of new properties and functionality.
Article
Biochemistry & Molecular Biology
Jana Radosinska, Tomas Jasenovec, Dominika Radosinska, Peter Balis, Angelika Puzserova, Martin Skratek, Jan Manka, Iveta Bernatova
Summary: USPIONs administration improved erythrocyte deformability and nitric oxide production in normotensive rats but not in hypertensive rats. Hypertensive rats showed significantly lower levels of USPION-originated iron in erythrocytes and faster elimination of USPIONs compared to normotensive rats.
Article
Polymer Science
Moises Bustamante-Torres, David Romero-Fierro, Jocelyne Estrella-Nunez, Belen Arcentales-Vera, Estefani Chichande-Proano, Emilio Bucio
Summary: In recent years, a wide range of nanomaterials, including magnetic nanoparticles, have been extensively studied for various purposes. Iron oxide nanoparticles and superparamagnetic iron oxide nanoparticles have attracted significant attention due to their physicochemical and magnetic properties, as well as their compatibility with organic or inorganic compounds. The incorporation of these nanoparticles into hydrogels has garnered interest in the field of biomedicine. This review discusses various synthesis methods for magnetite nanoparticles and introduces different processing techniques for magnetite-based nanocomposites in hydrogels. The characterization techniques commonly used to study magnetic nanoparticles and magnetic gels are also discussed.
Article
Biochemistry & Molecular Biology
Heba M. Fahmy, Taiseer M. Abd El-Daim, Omnia A. Ali, Asmaa A. Hassan, Faten F. Mohammed, Mohamed M. Fathy
Summary: The study found that iron mainly accumulated in the liver tissue, with the lowest liver accumulation observed after administration of Cit-IONPs or CS-IONPs. Administration of CS-IONPs showed the highest spleen iron accumulation, while the ferrous sulfate-treated group exhibited the highest kidney iron accumulation. Histopathological examination indicated that toxicity was more prevalent in groups treated with Cit-IONPs or commercial FeSO4, with Cur-IONPs and CS-IONPs showing milder toxicity at the same doses.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Magdalena Kulpa-Greszta, Anna Tomaszewska, Andrzej Dziedzic, Robert Pazik
Summary: The rapid hot-injection technique was used to synthesize magnetic nanoparticles with well-defined morphology, promoting particle growth and directional shaping. The use of hexadecane as a co-solvent affects monomer activity coefficient, forces shape-controllable growth, and enables particle downsizing. This approach can also be extended to other ferrites, which has not been previously achieved through the hot-injection process.
Article
Cell Biology
Kabir Ahluwalia, Juan-Carlos Martinez-Camarillo, Biju B. Thomas, Aditya Naik, Alejandra Gonzalez-Calle, Dimitrios Pollalis, Jane Lebkowski, Sun Young Lee, Debbie Mitra, Stan G. Louie, Mark S. Humayun
Summary: This study explored the use of human embryonic stem cell-derived, polarized retinal pigment epithelium soluble factors (PRPE-SF) as a combination treatment for retinal degenerative diseases. PRPE-SF promoted retinal progenitor cell survival and reduced oxidative stress, demonstrating potential for delaying retinal degeneration. Importantly, PRPE-SF treatment preserved retinal structure and function, offering a promising therapeutic candidate for these debilitating conditions.
Article
Physics, Applied
Zhongze Guo, Yong Hu
Summary: We conducted a numerical study on the magnetization behavior of self-assembled magnetite magnetic nanoparticles (MNPs) with diameters of 10 and 14 nm at room temperature using molecular dynamics simulations. The results showed that, in the absence of a magnetic field, isotropic growth of nano-sheets or nano-chains resulted in zero magnetization. Under a constant magnetic field, self-assembly occurred and the magnetization of the MNPs was found to be maximized at 0.05 T and decreased monotonically with increasing magnetic field strength. The arrangement of MNPs and their magnetic dipole orientations aligned with the magnetic field direction under weak magnetic fields, favoring the formation of long nano-belts and nano-chains. However, under strong magnetic fields, small nano-sheets and short nano-chains with different magnetic dipole orientations were formed. These results were attributed to the competition between magnetic dipole-dipole interaction and the magnetic field, with the critical separation between MNPs depending on their diameter and magnetic field strength.
APPLIED PHYSICS LETTERS
(2023)